5-Bromo-2-thiopheneacetonitrile

5-Bromo-2-thiophene acetonitrile is an important intermediate in organic synthesis. Its physical properties are white-like to light yellow crystalline powder at room temperature, with a specific odor. The melting point is within a certain range, and this characteristic can be used as a basis for identification when separating and purifying compounds.
On its chemical properties, because the molecule contains bromine atoms and cyanos, the chemical activity is quite high. Bromine atoms have good departure properties and are prone to nucleophilic substitution reactions. For example, under basic conditions with alcohols, bromine atoms can be replaced by alkoxy groups to form corresponding ether compounds. This reaction mechanism is that nucleophiles attack carbon atoms attached to positively charged bromine atoms, and bromine ions leave to form new carbon-oxygen bonds.
The cyanyl group is also active in nature and can participate in a variety of reactions. It can be hydrolyzed to form carboxyl groups under specific conditions, first converted into amide intermediates, and then further hydrolyzed to obtain carboxylic acids. It can also carry out reduction reactions. Under the action of suitable reducing agents, the cyanyl group is reduced to amino groups, providing a way for the synthesis of thiophene derivatives containing amino groups.
The reactivity and selectivity of 5-bromo-2-thiophene acetonitrile are significantly affected by reaction conditions such as temperature, solvent, catalyst, etc. Under suitable conditions, the expected conversion can be efficiently realized. It is widely used in the field of organic synthesis, in pharmaceutical chemistry, materials science, etc., and can be used to construct complex organic molecular structures.

5-Bromo-2-thiophene acetonitrile is also a compound commonly used in organic synthesis. The common synthesis methods are as follows.
First, 5-bromo-2-thiophene formaldehyde is used as the starting material. First, 5-bromo-2-thiophene formaldehyde is reacted with cyanide reagents such as sodium cyanide or potassium cyanide in an appropriate solvent, such as dimethyl sulfoxide (DMSO), under alkaline conditions. Sodium hydroxide or potassium hydroxide can be used as a base to promote the nucleophilic addition of cyano to aldehyde groups to generate 5-bromo-2-thiophene ethanolonitrile intermediates. Subsequently, the intermediate is used as a dehydrating agent, such as concentrated sulfuric acid or phosphorus pentoxide, to remove a molecule of water to obtain 5-bromo-2-thiophene acetonitrile. The steps of this method are relatively clear, and the starting materials are relatively easy to obtain. However, the cyanidation reagent is highly toxic, and extreme caution is required during operation, and the control of reaction conditions is also critical.
Second, 5-bromo-2-chloromethylthiophene is used as the raw material. React with sodium cyanide or potassium cyanide in a polar solvent such as N, N-dimethylformamide (DMF). This is a nucleophilic substitution reaction, in which cyanyl replaces the chlorine atom of chloromethyl to form the target product 5-bromo-2-thiophene acetonitrile. The reaction conditions of this method are relatively mild and the yield is considerable, but the preparation of 5-bromo-2-chloromethylthiophene may require additional steps.
Third, thiophene is used as the starting material, and the bromination reaction is carried out to introduce bromine atoms at the 5-position of thiophene to obtain 5-bromothiophene. 5-Bromothiophene is then acylated with chloroacetyl chloride, and chloroacetyl is introduced at the 2-position of thiophene. Finally, the product is reacted with sodium cyanide or potassium cyanide in a suitable solvent, and the cyanyl group replaces the chlorine atom to obtain 5-bromo-2-thiophene acetonitrile. Although this approach is simple in raw materials, there are many reaction steps, and each step needs to be carefully controlled to improve the total yield.

5-Bromo-2-thiophene acetonitrile is useful in various fields.
In the field of pharmaceutical synthesis, it is often a key intermediate. Due to its unique structure, it can introduce specific functional groups through various reactions to construct biologically active molecules. For example, when synthesizing specific antibacterial drugs, 5-bromo-2-thiophene acetonitrile can be combined with nitrogen-containing heterocyclic compounds through nucleophilic substitution reaction to generate new compounds with antibacterial efficacy. Such new compounds may act on specific targets of bacteria, impede the growth and reproduction of bacteria, and add new avenues to the research and development of antibacterial drugs. < Br >
In the field of materials science, it can also do something. It can be used to prepare polymer materials with special properties. Through its polymerization reaction with other monomers, the polymer is endowed with unique electrical and optical properties. For example, in the preparation of organic optoelectronic materials, the polymer formed by the reaction of 5-bromo-2-thiophenylacetonitrile may have good charge transport properties, which can be applied to devices such as organic Light Emitting Diode (OLED) or organic solar cells to improve the performance of such devices.
In the creation of pesticides, 5-bromo-2-thiophenylacetonitrile also plays an important role. After chemical modification, new high-efficiency pesticides can be developed. Such pesticides may have highly selective toxic effects on specific pests and are relatively friendly to the environment. For example, by adjusting its molecular structure, it can have a specific impact on the nervous system of crop pests, effectively control pests, and ensure crop yield and quality.
From this perspective, 5-bromo-2-thiophene acetonitrile has shown important application value in the fields of medicine, materials, and pesticides, providing assistance for the development of various fields.

For 5-bromo-2-thiophene acetonitrile, it is difficult to determine the price of the market. The price of the cover varies for many reasons, such as the supply and demand of the city, the amount of production, the quality of the quality, and the difference of time.
Looking back at the past, the supply and demand of the city are greatly related to the price. If there are many applicants and few suppliers, the price must increase; if the supply exceeds the demand, the price may fall. The amount of production also depends on the amount of production. The producer is large and the output is abundant, and the price may tend to be flat; if the producer is thin and the output is small, the price must be high. The quality of coarse is also the main reason for the price. Those who are of high quality have high prices, and those who are of poor quality have low prices. < Br >
And the times change, and the price is also different. In the past, the price was high, but now it is low. In the past, or due to the high price of raw materials and the increase in labor costs, the price rose; later, due to the progress of technology and the reduction in cost, the price may drop.
If you want to know the exact price, you can get a near-real price by consulting chemical material suppliers, trading houses, or market reports.

5-Bromo-2-thiophene acetonitrile is an organic compound. Its storage conditions are of paramount importance and are related to the quality and safety of this substance.
should be placed in a cool and dry place, away from direct sunlight. Sunlight can initiate many chemical reactions, causing the decomposition or deterioration of 5-bromo-2-thiophene acetonitrile. A cool place can slow down the movement of its molecules, reduce its interaction with the environment, and maintain its chemical stability.
must also be placed in a well-ventilated place. With good ventilation, volatile gases that may accumulate around can be removed, reducing the risk of explosion or poisoning. If it is in a closed place, the volatile 5-bromo-2-thiophene acetonitrile gas will gradually polymerize to a certain concentration, and it will be unexpected in case of open flame or static electricity.
And when it is isolated from oxidants, acids, bases, etc. In the structure of 5-bromo-2-thiophene acetonitrile, the activity of functional groups such as bromine and cyano is quite high, and it is easy to be oxidized when it encounters oxidants; in case of acid and alkali, or hydrolysis and other reactions, its structure will be damaged and its properties will be changed. < Br >
And where it is stored, the temperature should be controlled within an appropriate range, not too high to prevent it from evaporating and decomposing; nor too low to prevent it from solidifying, which will add a lot of inconvenience to access and use.
Packaging also needs to be strong and tight to prevent leakage. If it leaks outside, it will not only damage the material, but also pollute the environment and endanger human and animal health. In short, only when stored under these conditions can the quality and use of 5-bromo-2-thiophene acetonitrile be preserved.