5-bromo-1-benzothiophene

5-Bromo-1-benzothiophene is one of the organic compounds. Its physical properties are worth exploring.
Looking at its properties, 5-bromo-1-benzothiophene is mostly in a solid state at room temperature. This is due to the characteristics of intermolecular forces, the molecules attract each other tightly, so they condense into a solid state.
The melting point is about a specific range of values, which is crucial for the identification and purification of the substance. Due to the different purity of 5-bromo-1-benzothiophene, the melting point is slightly different, which can be used as the basis for quality determination.
The boiling point is also one of the important physical properties. Under specific pressure conditions, when the boiling point is reached, 5-bromo-1-benzothiophene changes from liquid to gaseous state. This property is of great significance in operations such as distillation and separation. 5-bromo-1-benzothiophene can be separated from the mixture by means of different boiling points.
In terms of solubility, 5-bromo-1-benzothiophene exhibits a certain solubility in organic solvents, such as some aromatic hydrocarbons and halogenated hydrocarbon solvents. This is based on the principle of similar phase dissolution, and its molecular structure interacts with the molecules of the organic solvent to dissolve it. However, in water, its solubility is very small, and the cap is difficult to dissolve due to the large difference in molecular polarity and water molecular polarity, and the weak interaction force.
In terms of color, pure 5-bromo-1-benzothiophene is often white to light yellow, and this color feature can also be used as a reference for preliminary identification. And the color change of its appearance may reflect its purity and whether it has undergone chemical changes.
In addition, the density of 5-bromo-1-benzothiophene is also a specific value. This property has important reference value in chemical operations involving volume and mass conversion, as well as in the process of material separation.

5-Bromo-1-benzothiophene is one of the organic compounds. It has many unique chemical properties and has attracted much attention in the field of organic synthesis.
Looking at its structure, the parent nucleus of benzothiophene is connected to the bromine atom. This bromine atom has high activity and is often used as a check point for nucleophilic substitution reactions. Because the bromine atom has strong electronegativity, its carbon-bromine bond polarity is significant, and the carbon is partially positively charged, making it vulnerable to nucleophilic reagents.
In the nucleophilic substitution reaction, halogen ions, alkoxide ions, amines and other nucleophiles can all replace the bromine atom of 5-bromo-1-benzothiophene, and then form new carbon-heteroatomic bonds to obtain various derivatives.
Furthermore, the benzothiophene parent nucleus of 5-bromo-1-benzothiophene has aromatic properties. This property makes its chemical properties relatively stable, but it can also participate in specific aromatic electrophilic substitution reactions. Under appropriate conditions, electrophilic reagents can attack the region with high electron cloud density in the parent nucleus of benzothiophene, realize the substitution reaction on the parent nucleus, and provide a pathway for compound modification and functionalization.
In addition, due to the presence of bromine atoms, 5-bromo-1-benzothiophene can participate in metal-catalyzed coupling reactions, such as Suzuki coupling, Stille coupling, etc. Such reactions can effectively form carbon-carbon bonds, which are widely used in complex organic molecules and material synthesis.
In conclusion, the rich chemical properties of 5-bromo-1-benzothiophene, and the characteristics of bromine atoms and benzothiophene parent nuclei, lay a solid foundation for diverse applications in organic synthesis and materials science.

5-Bromo-1-benzothiophene is also an organic compound. The common synthesis methods are about the following numbers.
First, benzothiophene is used as the starting material and obtained by bromination reaction. Among them, liquid bromine, N-bromosuccinimide (NBS), etc. can be brominated reagents. If liquid bromine is used, dichloromethane is often used as a solvent, and it is reacted at low temperature in the presence of catalysts such as iron powder or iron tribromide. Low temperature can inhibit the occurrence of side reactions, and the catalyst can promote the bromination reaction. The reaction mechanism is that the bromine molecule is polarized under the action of the catalyst to generate the active bromine positive ion, and then the electrophilic substitution reaction occurs with the aromatic ring of benzothiophene to obtain 5-bromo-1-benzothiophene.
Second, it is synthesized by cyclization from a suitable precursor containing sulfur and bromine. For example, using o-halogenated aryl thioether derivatives as raw materials, in the presence of bases and suitable ligands, they are cyclized by metals. Commonly used metal catalysts include palladium and copper. Bases can activate relevant chemical bonds in the raw material molecules, and metal catalysts guide the formation of intra-molecular rings, thereby constructing the structure of benzothiophene and introducing bromine atoms at specific positions. This approach requires careful design and synthesis of the structure of the precursor in order to accurately obtain the target product.
Third, with the help of the guide group strategy. A directable group is pre-introduced on the parent body of benzothiophene, which can guide the brominating reagent to selectively attack a specific position. After the bromination reaction is completed, the guide group is removed. This method can improve the regioselectivity of the reaction and effectively reduce the generation of by-products. However, the operation is more complicated, multi-step reaction is required, and the control of the reaction conditions is also stricter.

5-Bromo-1-benzothiophene is useful in many fields. In the field of pharmaceutical creation, this compound is a key raw material. The structure of Gain benzothiophene endows it with unique biological activity. By introducing bromine atoms into its structure, the electron cloud distribution of the molecule can be adjusted, thereby enhancing the interaction with biological targets. For example, when developing antibacterial drugs, 5-bromo-1-benzothiophene can be reacted in a series to construct compounds with specific antibacterial activities, or act on the cell wall synthesis of bacteria, or interfere with its nucleic acid metabolism, in order to achieve the effect of antibacterial and bactericidal.
It also plays an important role in the field of materials science. In the research and development of organic optoelectronic materials, 5-bromo-1-benzothiophene can participate in the synthesis of organic semiconductor materials. Its structure helps to form an orderly molecular accumulation and improve the charge transport performance of the material. The organic field effect transistor made from this can show good electrical properties and has great application prospects in the fields of flexible electronic devices. It can also be used to prepare organic Light Emitting Diode materials. After modification, it can adjust the luminous color and efficiency, which can help the development of display technology.
In the field of pesticide chemistry, 5-bromo-1-benzothiophene can be used as an intermediate for the synthesis of new pesticides. Utilize its special structure to create pesticides with high selectivity, low toxicity and environmental friendliness to pests. Or by interfering with the physiological processes of the nervous system and respiratory system of pests, the purpose of pest control can be achieved, while reducing the impact on non-target organisms, which is in line with the current needs of green agriculture development.
In summary, 5-bromo-1-benzothiophene plays an indispensable role in the fields of medicine, materials and pesticides, promoting technological progress and innovation in various fields.

5-Bromo-1-benzothiophene, it is difficult to generalize the price of this product in the market. The change in its price depends on many factors, and it is complicated.
First, look at the production method. Preparation of this compound, the process path is often different. If the method is refined and efficient, the production cost can be reduced, and the price may also drop accordingly. On the contrary, if the process is cumbersome, the materials used are expensive, and the yield is low, the cost will increase, and the price will be high in the market.
Second, the price of raw materials is also the key. The price of raw materials required for the synthesis of 5-bromo-1-benzothiophene fluctuates from time to time. If the raw materials are abundant and the supply is sufficient, the price will stabilize or decline; however, if the raw materials are scarce, or the origin changes and the supply is limited, the price will rise, causing the price of 5-bromo-1-benzothiophene to also rise.
Third, the state of market supply and demand determines its price. If at some point, the demand for 5-bromo-1-benzothiophene in many industries increases sharply, and the supply is difficult to respond in time, its price will soar. If the market demand is sluggish and the supply is excessive, the merchant may lower the price for promotional sales.
Fourth, the difference in quality also makes the price different. High purity, high quality 5-bromo-1-benzothiophene, due to the difficulty of preparation, high detection requirements, the regular price is higher than that of ordinary quality.
In the past, under specific market conditions, the price of 5-bromo-1-benzothiophene per gram may be between tens and hundreds of yuan. However, this is only an example of the past. Today, due to the above factors, the price is no longer fixed. To know the real-time market price, you need to consult the chemical raw material supplier in detail, or check it carefully on the chemical product trading platform to get an accurate number.