5-[bis(carboxymethyl)amino]-3-(carboxymethyl)-4-cyanothiophene-2-carboxylic acid

5 - [bis (carboxymethyl) amino] -3 - (carboxymethyl) -4 -cyanothiophene-2 -carboxylic acid, this is an organic compound. To clarify its chemical structure, analyze the information in each part of its name.
"Thiophene" is the parent nuclear structure of the sulfur-containing five-membered heterocycle, which is the core structure of the compound. In the "2-position" of the thiophene ring, there is a "carboxylic acid" group, which is composed of a carboxyl group (-COOH) and has acidic characteristics. < Br >
At the "3-position", there is a "carboxymethyl group", that is, the -CH -2 COOH structure, which is a methyl substituent containing a carboxyl group.
At the "4-position", there is a "cyano group", that is, a -CN group, which has high reactivity.
And at the "5-position", there is a "[bis (carboxymethyl) amino group]", which has a structure of -N (CH -2 COOH) -2. Here, the nitrogen atom is connected to two carboxymethyl groups, and this part is either amphoteric due to the amino and carboxylic groups, or acid-base.
In summary, the compound is centered on the thiophene ring and has different substituents at positions 2, 3, 4, and 5, respectively. Each substituent affects each other, giving the compound specific chemical and physical properties. It may have important uses in organic synthesis, medicinal chemistry, and other fields.

5 - [bis (carboxymethyl) amino] -3 - (carboxymethyl) -4 -cyanothiophene-2 -carboxylic acid This compound has a wide range of uses. In the field of pharmaceutical chemistry, it is often a key intermediate for the synthesis of specific drugs. Due to its unique structure, it can be chemically modified to introduce a variety of active groups to obtain compounds with unique pharmacological activities. For example, when developing targeted drugs for specific diseases, the structural properties of this compound may help to precisely target, enhance drug efficacy and reduce adverse reactions.
In the field of materials science, it also has potential functions. It can be combined with other organic or inorganic materials to improve material properties. Such as the preparation of functional polymer materials, by means of its carboxyl group, cyano group and other groups acting with the polymer skeleton, the material is endowed with special properties, such as enhanced hydrophilicity, chemical stability, or specific optical and electrical properties, suitable for the preparation of biological sensing, separation membranes and other materials.
Furthermore, in biochemical research, it can be used as a biochemical reagent. Because its structure contains multiple reactive groups, it can bind to biological macromolecules such as proteins and nucleic acids in a covalent or non-covalent manner for labeling and detecting biomolecules, assisting in the analysis of the structure and function of biomolecules, and exploring the chemical reaction mechanism in organisms.

5- [Bis (carboxymethyl) amino] -3 - (carboxymethyl) -4 -cyanothiophene-2 -carboxylic acid, this is an organic compound. Looking at its structure, it contains functional groups such as carboxyl groups, cyano groups and thiophene rings, which give it unique physical properties.
First, let's talk about solubility. Because it contains multiple carboxyl groups, this is a hydrophilic functional group, so the compound may have certain solubility in water. Carboxyl groups can interact with water molecules by hydrogen bonds to promote their dispersion in water. However, its thiophene ring and cyano group have certain hydrophobicity, or have restrictions on solubility, and the overall solubility may vary according to specific conditions.
As for the melting point, the intermolecular forces have a great influence on the melting point. In this compound, the carboxyl group can form hydrogen bonds, and the cyanyl group can also participate in weak interactions, which enhances the intermolecular forces. To make it melt, more energy is required to overcome these forces, so it is speculated that its melting point is higher.
In terms of stability, the thiophene ring has an aromatic structure and has a certain stability. However, the chemical properties of cyanyl groups are relatively active. Under specific conditions, in case of strong acids, strong bases or specific catalysts, or reactions occur, which affect the overall stability. Carboxyl groups may also undergo reactions such as decarboxylation under extreme acid-base conditions.
The physical properties of this compound are determined by its structure, and these properties are essential for its application in chemical synthesis, materials science and other fields, and need to be considered in detail according to the specific situation.

The synthesis method of 5- [bis (carboxymethyl) amino] -3- (carboxymethyl) -4-cyanothiophene-2-carboxylic acid is as follows:
First take the appropriate starting material, the starting material needs to contain the basic structure of thiophene, and reserve the activity check point for subsequent reaction at a specific position. Thiophene derivatives with suitable substituents can be found, such as those at the 2-position, 3-position, 5-position and other positions with groups that can be converted into carboxyl groups, cyano groups and other functional groups. < Br >
First, the cyanyl group is introduced at the 4-position of the thiophene ring. By nucleophilic substitution reaction, a suitable cyanylation reagent, such as potassium cyanide (KCN) or sodium cyanide (NaCN), under appropriate reaction conditions, such as in an organic solvent, a catalyst is added to promote the reaction, so that the cyanyl group replaces the original halogen atom or other easy-to-leave groups, so that the cyanyl group is successfully attached to the 4-position of thiophene.
Second, carboxymethyl groups are introduced at the 3-position and 5-position of the thiophene ring. Reaction with halogenated acetic acid or its esters can be carried out. Taking halogenated acetic acid as an example, under basic conditions, such as the presence of sodium hydroxide (NaOH) or potassium hydroxide (KOH), the halogen atom of halogenated acetic acid is easily attacked by nucleophiles. The active check point on the thiophene ring, after activation in the basic environment, acts as a nucleophile to attack the halogen atom of halogenated acetic acid, forming a carbon-carbon bond to achieve the introduction of carboxymethyl groups. This step may require a multi-step reaction and an appropriate protective group strategy to prevent unnecessary reactions at other check points.
Third, the [bis (carboxymethyl) amino group] is introduced at the 5-position. The amino intermediate can be formed by reacting with the 5-position substituent of thiophene with an appropriate aminating agent first. Subsequently, it is reacted with halogenated acetic acid, and two carboxymethyl groups are connected to the amino group one after another by nucleophilic substitution, thereby constructing the [bis (carboxymethyl) amino] structure.
During the reaction process, the reaction temperature, reaction time and the ratio of reactants need to be carefully adjusted to make the reaction sufficient and selective in each step. After each step of the reaction, it is appropriate to use appropriate separation and purification means, such as column chromatography, recrystallization, etc., to obtain a pure intermediate product, so as to facilitate the next step of the reaction, and finally obtain 5- [bis (carboxymethyl) amino] -3- (carboxymethyl) -4-cyanothiophene-2-carboxylic acid.

5- [bis (carboxymethyl) amino] -3- (carboxymethyl) -4-cyanothiophene-2-carboxylic acid is useful in many fields.
In the field of pharmaceutical research and development, its unique chemical structure may become a key component in the creation of new drugs. Due to the characteristics of thiophene and carboxyl, cyano and other groups, or with specific biological activities, such as acting on specific targets, in order to achieve disease treatment. Or it can be used to develop anti-tumor drugs, with its structure interacting with specific molecules of cancer cells, hindering the proliferation of cancer cells, inducing their apoptosis, and helping to solve cancer problems. < Br >
In the field of materials science, it can be used as a raw material for functional materials. Because it contains a variety of functional groups, it can participate in material synthesis reactions and endow materials with unique properties. For example, the preparation of polymer materials with special adsorption and separation properties, using its carboxyl groups to interact with specific substances to achieve high-efficiency adsorption and separation of specific molecules, and it is very useful in chemical separation and environmental monitoring.
also has potential applications in the field of agriculture. Or it can be developed into a new type of pesticide or plant growth regulator by rational design and modification. Its chemical structure may bind to specific receptors in plants to regulate plant growth and development, improve crop yield and quality; or it has inhibitory and killing effects on some pests and pathogens, providing new options for the development of green agriculture.
Furthermore, in the field of organic synthetic chemistry, as an important intermediate, it can participate in the synthesis of many complex organic compounds. With its rich functional groups, through various organic reactions, diverse and complex molecular structures can be constructed, promoting the development of organic synthetic chemistry and opening up a broad space for the creation of new substances.