5-amino-4-cyano-3-methyl-thiophene-2-carboxylic acid ethyl e

This is the chemical structure analysis of 5-amino-4-cyano-3-methyl-thiophene-2-carboxylic acid ethyl ester. Looking at its name, its structure can be gradually inferred. "Thiophene" is the basic structure of the sulfur-containing five-membered heterocyclic ring, which is the core skeleton of the compound.
"5-amino", indicating that the amino group is attached to the 5th position of the thiophene ring; "4-cyano", pentacyano is at the 4th position of the thiophene ring; "3-methyl", epityl is at the 3rd position of the thiophene ring. And "ethyl 2-carboxylate" means the group where the thiophene ring is connected to ethyl monocarboxylate at the 2nd position.
Graphically, the thiophene ring is centered, and the upper 5-position is connected to amino (-NH ²), 4-position cyanide (-CN), 3-position pendant methyl (-CH 🥰), and 2-position is connected to carboxylic acid ethyl ester (-COOCH 🥰 CH 🥰). In this way, the chemical structure of 5-amino-4-cyano-3-methyl-thiophene-2-carboxylate ethyl ester is clearly presented in front of us.

Ethyl 5-amino-4-cyano-3-methyl-thiophene-2-carboxylate is an organic compound. Its physical properties are quite important, and it is significant in many fields such as chemical industry and medicine.
Looking at its appearance, it is often white to white-like crystalline powder, which is as pure as snow, and as uniform as fine silt. This form is easy to store and transport, and is easy to handle in many industrial processes.
When it comes to melting point, it is in a specific temperature range. This property is crucial for the purification, identification and control of the reaction process of compounds. When the temperature gradually rises near the melting point, the compound will slowly transform from a solid state to a liquid state, melting like ice and snow, following the inherent laws of matter.
Solubility is also one of the key physical properties. It exhibits a certain solubility in common organic solvents such as ethanol and acetone, just like fish entering water and can be evenly dispersed in it. However, its solubility in water is poor, just like oil and water are difficult to melt. This difference determines the direction of consideration when separating, purifying and selecting reaction solvents.
Density is also a property that cannot be ignored. Although the value may not be insignificant, it plays a role in material balance and product quality control. Its density gives the compound the weight and volume relationship in a specific environment, providing accurate data support for actual production operations.
The above several physical properties, such as appearance state, degree of melting point, solubility, and density value, are related to each other, and together outline the physical characteristics of 5-amino-4-cyano-3-methyl-thiophene-2-carboxylic acid ethyl ester, laying a solid foundation for its application in various fields.

5-Amino-4-cyano-3-methyl-thiophene-2-carboxylate ethyl ester, which has a wide range of uses. In the field of pharmaceutical synthesis, it is often a key intermediate. Due to its unique chemical structure, it can be converted into many compounds with specific pharmacological activities through various chemical reactions. Or it can be used to create antibacterial drugs, which interfere with the metabolic process of pathogens by virtue of their structure and physiological characteristics of pathogens, and achieve the effect of inhibiting the growth and reproduction of pathogens; or it can be used to develop anti-cancer drugs, which can block the proliferation path of cancer cells by precisely acting on specific targets of cancer cells, thus providing an important cornerstone for the creation of anti-cancer drugs.
In the field of materials science, this compound also shows potential application value. Because its structure contains specific functional groups, or it can be treated by special processes to prepare materials with unique photoelectric properties. Such materials may emerge in the field of organic Light Emitting Diode (OLED), improving the luminous efficiency and stability of devices, and contributing to the development of display technology; or making achievements in solar cell materials, enhancing the ability to capture and convert light energy, thereby improving the photoelectric conversion efficiency of solar cells.
Furthermore, in the fine chemical industry, 5-amino-4-cyano-3-methyl-thiophene-2-carboxylate ethyl ester can be used as an important raw material for the synthesis of special dyes or fragrances. After clever chemical modification and synthesis steps, the dyes are endowed with more vivid color and excellent light resistance and washable properties; adding unique aroma characteristics and durability to fragrances to meet the market demand for high-quality fine chemicals.

The synthesis method of ethyl 5-amino-4-cyano-3-methyl-thiophene-2-carboxylate has existed in ancient times, and is described in detail below.
First, the compound containing thiophene structure can be started. First, a methyl group is introduced at a specific position on the thiophene ring with a suitable reagent under specific reaction conditions. This step requires careful control of the reaction temperature, time and reagent dosage. Too high or too low cap temperature, too long or too short time, too much or too little reagent may all affect the yield and selectivity of the reaction. Usually, appropriate halogenated methane and alkali are selected to react in an organic solvent, such as potassium carbonate as a base and acetonitrile as a solvent, and the reaction is stirred at a certain temperature to achieve the purpose of methylation.
Second, the cyanyl group is introduced. Commonly used cyanide reagents, such as potassium cyanide or sodium cyanide, react with methylated thiophene derivatives. This reaction requires attention to safety, because cyanide is highly toxic. During the reaction, it is appropriate to carry out under mild conditions, or the reaction can be promoted by means of catalysts, such as some transition metal catalysts, which can precisely connect the cyanyl group to the target position of the thiophene ring.
Then, a carboxyl ethyl ester group is introduced into the thiophene ring. Generally, it can be achieved by reacting with halogenated ethyl acetate under alkaline conditions. In this process, factors such as the strength and dosage of the base, the polarity of the reaction solvent, etc., have a great influence on the reaction process. Select suitable bases, such as sodium hydride, and react in an anhydrous environment, which can improve the reaction efficiency.
Furthermore, introduce amino groups. Nitro reduction can often be used to introduce nitro groups to thiophene derivatives first, and then convert nitro groups into amino groups through reduction reactions. There are many reduction methods, such as catalytic hydrogenation, using palladium carbon as a catalyst and reacting in a hydrogen atmosphere; chemical reduction methods can also be used, such as iron powder, hydrochloric acid, etc. as reducing agents for reaction.
All synthetic methods have their own advantages and disadvantages. In practical application, it is necessary to weigh the cost of raw materials, the difficulty of reaction conditions, the yield and the purity of the product according to the specific situation, and choose the best one to use. To achieve the purpose of efficient synthesis of 5-amino-4-cyano-3-methyl-thiophene-2-carboxylate.

I look at your question, but I am inquiring about the price range of 5-amino-4-cyano-3-methyl-thiophene-2-carboxylic acid ethyl ester in the market. However, the price of these materials often varies due to many factors.
First, the purity of the material is the key. If the purity is extremely high and almost flawless, the price will be high; if it contains a little impurities, the price may drop slightly. Second, the purchase quantity also has an impact. If you buy in bulk, merchants may reduce the price for profit; if you buy a small amount, the price may be high. Third, the market supply and demand situation cannot be ignored. If the demand for this product is strong and the supply is low, the price will increase; on the contrary, if the supply exceeds the demand, the price may fall.
According to past circumstances and market conditions, the price of this 5-amino-4-cyano-3-methyl-thiophene-2-carboxylic acid ethyl ester per gram may be as low as tens of yuan, if the purity is high and the purchase quantity is small, it may reach several hundred yuan. However, this is only a rough estimate, and the actual price needs to be consulted with the relevant suppliers in detail, depending on the current specific situation.