5-Acetylbenzothiophene

5-Acetylbenzothiophene is one of the organic compounds. It has a wide range of uses and has important applications in many fields.
First, in the field of pharmaceutical chemistry, 5-acetylbenzothiophene is often used as a key intermediate. Drug developers can synthesize compounds with specific biological activities by modifying and modifying their chemical structures. For example, some derivatives prepared on this basis have been shown to have potential efficacy in the treatment of specific diseases. Due to the structural properties of the compound, it can interact with specific targets in organisms, thereby regulating physiological processes and providing important starting materials and ideas for the creation of new drugs.
Second, in the field of materials science, 5-acetylbenzothiophene is also of great value. Due to its unique electronic structure and chemical properties, it can be used to prepare materials with special photoelectric properties. During the research and development of optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells, materials containing 5-acetylbenzothiophene structures can effectively improve the performance of devices, such as enhancing luminous efficiency and improving energy conversion efficiency. This is because the compound can undergo specific physical and chemical changes under the action of light and electricity to meet the requirements of optoelectronic devices for material properties.
Thirdly, in the field of organic synthetic chemistry, 5-acetylbenzothiophene is an important synthetic building block. Chemists can use it to construct various complex organic molecules according to the principles and methods of organic synthesis. By ingeniously designing reaction paths and combining them with other organic reagents, organic compounds with diverse structures and functions can be prepared, enriching the types of organic compounds and promoting the development of organic synthetic chemistry.
In summary, 5-acetylbenzothiophene, with its unique structure and properties, plays an indispensable role in many key fields such as medicinal chemistry, materials science, and organic synthetic chemistry, providing an important material foundation and technical support for the development of various fields.

5-Acetylbenzothiophene, also an organic compound. It has unique physical properties and is detailed below:
first melting point, the melting point of this material is usually between 48-52 degrees Celsius. Melting point, the temperature limit of the substance from the solid state to the liquid state, the melting point range of 5-acetylbenzothiophene, so that it undergoes a phase transition in a specific temperature range. In chemical experiments and industrial production, the melting point is an important indicator, which is related to the purification, crystallization and other operations of the substance.
times and boiling point, about 344.4 degrees Celsius. The boiling point is the temperature at which the saturated vapor pressure of the liquid is equal to the external pressure. The boiling point of 344.4 degrees Celsius indicates that this temperature is required to make 5-acetylbenzothiophene boil and vaporize. This property is of great significance in processes such as distillation and separation.
Furthermore, the density is about 1.26 g/cm ³. In terms of density, the mass of a substance per unit volume. This density value reflects the difference in density from other substances. In a mixed system, it is related to the phenomenon of stratification and dispersion of the substance.
In terms of solubility, 5-acetylbenzothiophene is insoluble in water, but it can be soluble in common organic solvents such as ethanol, ether, chloroform, etc. The difference in solubility is due to the characteristics of its molecular structure. Water molecules are polar molecules, while 5-acetylbenzothiophene molecules have weaker polarity. According to the principle of "similar miscibility", it is easily soluble in organic solvents with similar polarity. This property provides a basis for the selection of solvents in organic synthesis reactions.
In appearance, 5-acetylbenzothiophene often takes the form of a white-like to light yellow crystalline powder. This appearance feature can be used as a reference for the preliminary identification of the substance. By observing its color and morphology with the naked eye, the purity and authenticity of the substance can be preliminarily judged. In conclusion, the melting point, boiling point, density, solubility and appearance of 5-acetylbenzothiophene are of great significance for its application in chemical research, industrial production and related fields.

5-Acetylbenzothiophene is also an organic compound. The stability of its chemical properties is related to multiple ends.
In terms of structure, the benzothiophene ring is connected to the acetyl group. The benzothiophene ring has a certain aromaticity and imparts a certain stability to the molecule. Electrons in the aromatic system are delocalized, which can disperse energy and stabilize the molecule. The acetyl group is connected to the benzene ring. Although the carbonyl group has a certain polarity and reactivity, under appropriate conditions, it also interacts with the benzothiophene ring to maintain the overall structural stability.
In common chemical environments, if there is no active reagent or specific conditions, 5-acetylbenzothiophene can maintain a relatively stable state. For example, under extreme conditions such as normal temperature and pressure, dry and no light, it can be stored for a long time without significant change.
But in case of strong oxidizing agents, the carbonyl group may be oxidized, resulting in structural changes. In case of strong oxidizing reagents such as potassium permanganate, the carbonyl group of the acetyl group may be further oxidized to a carboxyl group, etc. In case of nucleophilic reagents, carbonyl carbon is susceptible to nucleophilic attack due to its partial positive electricity, triggering reactions such as nucleophilic addition, and destroying the original stable structure.
When exposed to high temperature or light, the intra-molecular energy increases, the electron excites, or the bond breaks and rearrangements are triggered, which affects its stability. However, under conventional laboratory and industrial storage and use conditions, the chemical properties of 5-acetylbenzothiophene can still be maintained, meeting many reaction and application requirements.

The synthesis method of 5-acetylbenzothiophene has been different in ancient times, and now I will choose the main one to describe it.
First, benzothiophene is used as the starting material and is prepared by acylation reaction. First, take an appropriate amount of benzothiophene, place it in a reactor, add an appropriate amount of catalyst, such as anhydrous aluminum trichloride, etc., and re-inject an appropriate amount of acetylation reagent, such as acetyl chloride or acetic anhydride. At a suitable temperature and reaction time, the acylation reaction occurs between the two. In this reaction, the catalyst can effectively promote the reaction, accelerate the combination of benzothiophene and acetylation reagent, so that the specific position on the benzene ring is substituted to form 5-acetylbenzothiophene. The reaction mechanism is that the catalyst interacts with the acetylation reagent to form an active intermediate, and then launches an electrophilic attack on the benzene ring of benzothiophene to achieve the 5-position acetyl substitution.
Second, through the strategy of constructing benzothiophene ring. First select compounds containing sulfur and compounds containing benzene rings, such as o-halogenated thiophenol and enone compounds. Under the catalysis of bases, the two first undergo cyclization to construct the parent nuclear structure of benzothiophene. Then, the obtained benzothiophene derivative is modified by acetylation. In this process, the alkali can activate the reactant and promote its cyclization. The subsequent acetylation reaction can be controlled according to the specific reaction sequence and conditions according to the above acylation conditions to achieve the synthesis of 5-acetylbenzothiophene.
Third, by means of transition metal catalysis. Select suitable transition metal catalysts, such as complexes of metals such as palladium and copper, and use halides containing benzothiophene structures and acetylation reagents as raw materials. Under the synergistic action of ligand and base, transition metal catalysts can catalyze the coupling reaction between the two to obtain 5-acetylbenzothiophene. This method relies on the unique electronic structure and catalytic activity of transition metal catalysts to achieve precise chemical bond construction, and has the advantages of relatively mild reaction conditions and high selectivity. During the reaction process, transition metals and ligands form stable catalytic active centers, and a series of steps such as oxidative addition, migration insertion, and reduction elimination occur with the reactants to complete the synthesis of the target product.

5-Acetylbenzothiophene, the price of this product in the market, it is difficult to set quickly. Covers the change in its price, subject to various factors.
At the beginning of the raw material end, if the raw material for synthesizing 5-acetylbenzothiophene is synthesized, it is difficult to obtain and the price is high or low, all of which are related. If the raw materials are abundant and cheap, the price of 5-acetylbenzothiophene may become easier; if the raw materials are scarce and difficult to find, the price will rise, and it will also be expensive.
The simplicity of the process is also a major reason. If the synthesis method is complicated, requires many steps, uses various reagents, takes a long time, and the equipment requirements are very high, the cost will increase, and the price will not be low; if the process is simple, the cost will decrease, and the price will also decrease.
Furthermore, the market supply and demand situation also affects its price. If there are many people in the market who want to buy 5-acetylbenzothiophene, but the supply is limited, the supply is in short supply, and the price will rise; if the supply exceeds the demand, the merchant may reduce the price to sell.
In addition, the brand and quality of the manufacturer are also related to the price. Well-known large factories, strict quality control, high-quality producers, and their prices may be higher than ordinary manufacturers.
According to common sense, the price of 5-acetylbenzothiophene per gram may be between tens of yuan and hundreds of yuan. However, this is only an approximate number, and the actual price must be based on the time and the city, and the chemical raw material suppliers can be confirmed in detail. The market is not constant, and the price is uncertain. If you want to know the true price, you should visit it in person.