5-(2-MERCAPTOTHIAZOL-4-YL)THIOPHENE-2-CARBOXAMIDE

5- (2-mercaptothiazole-4-yl) thiophene-2-formamide has a wide range of uses. In the field of medicinal chemistry, it is often a key raw material for the creation of new drugs. Due to its unique structure and potential biological activity, the compound can target specific diseases, such as certain inflammatory and tumor diseases. By ingeniously modifying and modifying its molecular structure, it is expected to develop therapeutic drugs with excellent efficacy.
In the field of materials science, 5- (2-mercaptothiazole-4-yl) thiophene-2-formamide also has important uses. Due to its special chemical properties, it can be used as a component of functional materials, giving materials such as unique optical and electrical properties. It is used in the manufacture of optoelectronic devices, such as organic Light Emitting Diodes, solar cells, etc., to help improve device performance and efficiency.
In addition, in the research and development of pesticides, this compound also has room to be tapped. In view of its role in specific biological activities, through rational design and testing, high-efficiency and low-toxicity pesticide products may be developed to control crop diseases and pests, ensure the harvest of agricultural production, and maintain the balance of the ecological environment. In conclusion, 5- (2-mercaptothiazole-4-yl) thiophene-2-formamide has important application value in many scientific and technological fields, providing key support and broad exploration space for the development of related fields.

5- (2-mercaptothiazole-4-yl) thiophene-2-formamide, this compound is an organic compound with unique chemical properties. Its structure contains thiophene and thiazole heterocycles, which are connected by specific chemical bonds, giving the compound a variety of chemical activities.
From the perspective of physical properties, this compound is usually in a solid state, but its appearance may be slightly different due to differences in specific preparation and purification processes. In terms of melting point, due to intermolecular forces and structural characteristics, its melting point is in a specific range, and the exact value needs to be determined experimentally.
When it comes to chemical activity, the thiol group (-SH) in its molecule is extremely active. Sulfur atoms in thiol groups have solitary pair electrons and are easy to participate in chemical reactions. For example, in nucleophilic substitution reactions, sulfur atoms can be used as nucleophiles to attack suitable electrophilic reagents and form new chemical bonds, thereby synthesizing compounds with more complex structures.
Furthermore, thiophene and thiazole heterocycles also affect their chemical properties. The heterocycle system has certain stability due to the conjugation effect, and at the same time endows the molecule with a unique electron cloud distribution, so that the compound exhibits special optical and electrical properties. For example, under specific conditions, it may be able to absorb and emit light of specific wavelengths, which has potential application value in the field of optical materials.
In addition, formamide groups (-CONH2O) also contribute to the reactivity of molecules. This group can participate in the formation of hydrogen bonds, which affects the solubility of compounds and intermolecular interactions. Under appropriate conditions, formamide groups can also undergo hydrolysis, aminolysis and other reactions to derive a variety of compounds.
5- (2-mercaptothiazole-4-yl) thiophene-2-formamide has rich chemical properties, laying the foundation for research and application in organic synthesis, materials science and other fields.

To prepare 5- (2-mercaptothiazole-4-yl) thiophene-2-formamide, the method is as follows:
First take an appropriate amount of 2-bromothiophene-5-formamide, place it in a reactor, add an appropriate amount of organic solvent, such as dichloromethane, to fully dissolve the material. This is to create a uniform environment for the reaction.
In another container, prepare a sulfur-containing nucleophilic reagent. For example, thiourea reacts with alkali to generate nucleophilic sulfur negative ions. For specific operations, thiourea can be slowly added to alkali, such as sodium hydroxide solution, and stirred to fully react.
Then, carefully drop the prepared sulfur-containing nucleophilic reagent into a reactor containing a 2-bromothiophene-5-formamide solution, while maintaining the reaction temperature in a moderate range, such as 30 to 50 degrees Celsius. This temperature not only helps the reaction to proceed, but also avoids the excessive occurrence of side reactions. During the reaction, continue to stir to promote full contact of the reactants and accelerate the reaction process.
After the reaction has been carried out for a certain period of time, monitor the reaction process by thin layer chromatography or high performance liquid chromatography until the raw material point disappears or reaches the expected reaction level.
After the reaction is completed, pour the reaction mixture into an appropriate amount of water, extract the product with an organic solvent, and merge the organic phases after multiple extractions. The organic phase is then dried with anhydrous sodium sulfate to remove residual moisture.
Finally, the organic solvent is removed by reduced pressure distillation to obtain a crude product. The crude product is purified by column chromatography or recrystallization, and a suitable eluent or solvent is selected, such as a mixed solvent of petroleum ether and ethyl acetate for column chromatography, and ethanol for recrystallization. Pure 5- (2-mercaptothiazole-4-yl) thiophene-2-formamide can be obtained.

I don't know the price range of 5- (2-mercaptothiazole-4-yl) thiophene-2-formamide in the market. This is a rather specialized and specific chemical, and its price is determined by many factors.
First, the purity has a great impact. For high purity, the preparation is difficult, the process is complicated, and the cost is also high, and the price will be high; for low purity, the preparation is easier, the cost is slightly lower, and the price is relatively low.
Second, the amount of output is also related. If it is produced in large quantities, due to the scale effect, the unit cost may be reduced, and the price may decrease; if the output is scarce, the scarcity is rare, and the price is often high.
Third, the market supply and demand situation is the key factor. If the demand is strong and the supply is insufficient, the price will rise; if the demand is low and the supply is excessive, the price will easily fall.
Fourth, the differences in manufacturers also have an impact. Different manufacturers have different technical levels and production costs, and the pricing will be different.
Because I don't know the details of its specific purity, output, supply and demand, and manufacturers, it is difficult to know its price range. For the exact price, you can consult chemical product suppliers, chemical trading platforms or relevant industry insiders. They can give accurate prices according to real-time market conditions and specific requirements.

5- (2-mercaptothiazole-4-yl) thiophene-2-formamide is a special chemical that is very important for its safety precautions. Details are as follows:
First, this chemical may be toxic and can cause many damages to the human body. It may irritate the skin, causing redness, itching, and even rash. If it comes into contact with the eyes, it can cause severe eye pain, redness, and swelling, and in severe cases it can damage vision. Inhalation of its dust or volatiles can irritate the respiratory tract, causing cough, asthma, and long-term exposure or increase the risk of respiratory diseases. Ingestion into the body, or injury to the stomach, causing nausea, vomiting, abdominal pain, etc. Therefore, when handling this substance, be sure to take good protection. Wear protective clothing to avoid skin contact; wear protective glasses to protect your eyes; wear a mask to prevent inhalation.
Second, this chemical also has potential harm to the environment. If accidentally released into the environment, it may cause pollution to water, soil, air, etc. In the aquatic environment, it may endanger the survival and reproduction of aquatic organisms and destroy the ecological balance. In the soil, it may affect the activity of soil microorganisms and plant growth. In the air, its volatiles may participate in atmospheric chemical reactions and affect air quality. Therefore, when using, it needs to be strictly controlled to prevent leakage. If there is a leak, proper measures should be taken immediately to clean it up to avoid the spread of pollution.
Third, there are strict requirements for storing this chemical substance. It should be stored in a cool, dry, well-ventilated place, away from fire and heat sources. Because of its flammability, there is a risk of combustion and explosion in case of open flames and hot topics. And should be stored separately from oxidants, acids, alkalis, etc., because of their active chemical properties, contact with these substances or cause violent reactions. The storage area should be equipped with suitable materials to contain leaks.
Fourth, when using this chemical substance, the experimental operation should be rigorous and standardized. Precisely weigh and control the reaction conditions, follow the established operating procedures, and must not be changed at will. After the operation, thoroughly clean the instruments and equipment to prevent residual substances from affecting the next experiment or causing safety accidents. At the same time, the laboratory must be equipped with emergency rescue equipment and medicines, such as eye washers, sprinklers, first aid medicines, etc., for emergencies.