5-(2-Bromo-acetyl)-thiophene-2-carboxylic acid amide

The chemical structure of 5- (2-hydroxyethylamino) pentanitrile-2-chloroacetate phenyl ester is one of the structures of organic compounds. This compound structure is composed of several parts of groups.
Its structure, 5- (2-hydroxyethylamino) pentanitrile part, pentanitrile is a cyanide-containing pentane structure, in the No. 5 carbon position of pentane, connected to the (2-hydroxyethylamino) group. This (2-hydroxyethylamino) is an amino group connected to the 2-hydroxyethyl group, and the No. 2 carbon position of ethyl group is connected with a hydroxyl group.
And the phenyl ester part of 2-chloroacetate, the phenyl ester is connected to the benzene ring and the ester group, and the acyl group of this ester group is provided by chloroacetic acid. In chloroacetic acid, a hydrogen atom on the methyl group of acetic acid is substituted by a chlorine atom, and the substituted chloroacetic acid is connected to the benzene ring through an ester bond, and the ester group is connected at the carbon position of the benzene ring No. 2.
These two are connected to form the overall chemical structure of 5 - (2-hydroxyethylamino) pentanitrile-2-chloroacetic acid phenyl ester. Such a structure endows the compound with specific physical and chemical properties, which can be used in organic synthesis and related chemical fields, or have specific uses and reactivity, and can exhibit different chemical behaviors in response to different chemical reaction conditions.

5- (2-hydroxyethylamino) glutaric acid-2-carboxylaminobenzamide, which is a key intermediate commonly used in the field of organic synthesis. Its main uses are as follows:
First, in the field of medicinal chemistry, it has made great contributions to the construction of many drug molecules. In the synthesis path of many drugs with specific physiological activities, 5- (2-hydroxyethylamino) glutaric acid-2-carboxylaminobenzamide is an important building block. Taking some anti-tumor drugs as an example, through ingenious modification and modification of their structures and access to specific functional groups, new drug molecules with targeting tumor cells and inhibiting tumor growth and diffusion can be obtained. Due to its structure containing a variety of active checking points, it can precisely combine with specific targets in tumor cells to achieve efficient treatment.
Second, it also has important applications in the field of materials science. Due to its special chemical structure, it can participate in the synthesis of polymer materials as a monomer. By copolymerizing with other monomers, polymer materials are endowed with unique properties. For example, polymer materials with good biocompatibility and degradability are synthesized, which are used in the field of biomedical engineering to prepare tissue engineering scaffolds, drug slow-release carriers, etc. This material can be slowly degraded in vivo, providing a suitable microenvironment for cell growth, and assisting tissue repair and regeneration.
Third, in organic synthesis chemistry, it is an important precursor for the synthesis of complex organic compounds. With its rich reaction check points in its structure, it can construct a variety of organic molecular structures through a series of organic reactions, such as amidation, esterification, nucleophilic substitution, etc. Organic chemists can use this to design and synthesize organic compounds with novel structures and properties, injecting new vitality into the development of organic synthetic chemistry and promoting the continuous expansion of the field.

To prepare 5- (2-cyanoethoxy) pentanitrile-2-carboxylate sodium ethyl ester, the synthesis method is as follows:
First, start with common raw materials, and select compounds containing appropriate functional groups. If a compound containing alcohol hydroxyl is reacted with bromocyanoethane, this step needs to be carried out in a suitable alkaline environment to convert the alcohol hydroxyl group into sodium alcohol, and then undergo nucleophilic substitution reaction with bromocyanoethane to obtain 2-cyanoethoxy derivatives. During this reaction process, the reaction temperature and time need to be precisely controlled. If the temperature is too high, it is easy to cause side reactions, and if the temperature is too low, the reaction rate is too slow.
Subsequently, the obtained 2-cyanoethoxy derivative is condensed with another compound containing valeronitrile-2-carboxylic acid ethyl ester structure. In this step, a suitable condensing agent, such as dicyclohexylcarbodiimide (DCC), can be used to promote the condensation of the two under mild conditions. During the condensation process, close attention should be paid to the pH of the reaction system and the ratio of the reactants. Improper ratio can easily lead to impure products.
Furthermore, the condensation product is properly hydrolyzed and treated with basic reagents such as sodium hydroxide to hydrolyze the ester group into sodium carboxylate salt, thereby obtaining the target product 5- (2-cyanoethoxy) pentanitrile-2-carboxylate sodium ethyl ester. During the hydrolysis reaction, attention should be paid to the concentration and reaction time of the base to avoid excessive hydrolysis affecting the quality of the product.
Synthesis of this compound requires fine operation in each step and strict control of the reaction conditions to improve the purity and yield of the product.

5- (2-hydroxyethylamino) glutaric acid-2-carboxyanilinamide, this compound has the following physical properties:
Its appearance is often white to slightly yellow crystalline powder, which is more stable at room temperature and pressure. The melting point is usually within a certain range, and the specific value varies slightly due to factors such as purity. Generally speaking, the melting point of compounds of this type of structure is relatively high, which makes it exist in solid form at common ambient temperatures.
In terms of solubility, its solubility in water is limited, slightly soluble in cold water, but with the increase of temperature, the solubility in water will increase. For organic solvents, it can have a certain solubility in some polar organic solvents such as ethanol and acetone, but it has very little solubility in non-polar organic solvents such as n-hexane and benzene, and is almost insoluble.
Density also has a specific value, which is closely related to its molecular structure, and the density is moderate, which is helpful for separation and purification in actual operation. It also has a certain degree of hygroscopicity. In a high humidity environment, it will absorb a certain amount of water, which will affect its physical state and purity. Therefore, it is necessary to pay attention to moisture protection when storing. In addition, the stability of this compound allows it to be stored for a long time under conventional conditions. However, under extreme conditions such as high temperature, strong acid, and strong base, its molecular structure may change, causing chemical properties to change, thus affecting its performance.

5- (2-hydroxyethylamino) glutaric acid-2-carboxyvaleramide requires attention to many matters during storage and transportation.
First, due to its chemical properties, it should be placed in a cool, dry and well-ventilated place. Such an environment can avoid deterioration caused by excessive temperature and humidity. If stored in a humid place, it may cause moisture absorption and affect quality; if the temperature is too high, it may accelerate the rate of chemical reactions, resulting in decomposition or other adverse changes.
Second, it needs to be stored separately from oxidizing agents, acids, bases and other chemicals. This is due to the chemical reaction of 5 - (2 - hydroxyethylamino) glutaric acid - 2 - carboxyvaleramide or with these substances, or the danger of combustion and explosion. For example, contact with strong oxidants may react violently, releasing a lot of heat, which may cause fire or even explosion.
Third, ensure that the packaging is complete and sealed during transportation. If the packaging is damaged, the product or leakage will not only cause losses, but also may pose a threat to the environment and the safety of transportation personnel. Moreover, the transportation process should be smooth, avoid bumps and collisions, and prevent packaging damage.
Fourth, storage and transportation sites should be equipped with corresponding fire equipment and leakage emergency treatment equipment. In the event of an accident, it can respond quickly. In the event of a fire, fire fighting equipment can be used in time to put out the fire; if there is a leak, emergency treatment can be carried out immediately to prevent the spread of pollution.
Finally, whether it is storage or transportation, it must be managed and recorded by a special person. Detailed records of warehousing time, quantity, storage conditions and other information can be traced and managed to detect and solve possible problems in time.