5-(1H-Pyrazol-4-yl)thiophene-2-carboxylic Acid

The function of 5- (1H-pyrrole-4-yl) imidazole-2-carboxylic acid is particularly important in the process of medicine. It can be used as a key intermediate in drug synthesis and plays an important role in the creation of new drugs.
Guanfujin's pharmaceutical research and development, many drug molecules with special pharmacological activities rely on this structure. Due to its unique chemical structure, it can precisely fit with specific targets in organisms, like tenon and mortise interlocking, so as to play a role in regulating physiological functions and healing diseases.
In the development of anti-cancer drugs, 5- (1H-pyrrole-4-yl) imidazole-2-carboxylic acid may be modified to target specific proteins or signaling pathways of cancer cells, block the proliferation and metastasis of cancer cells, and achieve the purpose of anti-cancer. Like a target in the fine vector, it directly targets the source of the disease.
And in the exploration of drugs for neurological diseases, it may regulate the release and transmission of neurotransmitters, improve the function of nerve cells, and help the treatment of diseases such as Alzheimer's disease and Parkinson's disease. Just like repairing the disordered veins and restoring nerve conduction to normal track.
And because of its good reactivity in the field of organic synthesis, chemists can use various chemical reactions to ingeniously derive its structure and expand its application in medicinal chemistry and other related fields. In this way, this compound is like a shining star in the medical world, illuminating the way forward for the development of new drugs and providing infinite possibilities for human health and well-being.

5- (1H-pyrrole-4-yl) imidazole-2-carboxylic acid, this substance is an organic compound. Its physical properties are as follows:
Looking at its morphology, at room temperature, it is mostly in a solid state, but there may be subtle differences depending on the preparation process and purity.
When it comes to color, pure people often appear white to quasi-white. If it contains impurities, the color may change.
Smell the smell, generally without a special strong smell, only a very weak inherent smell of organic compounds. < Br >
In terms of solubility, the solubility in water is limited, and the cap is caused by the ratio of polar groups to non-polar parts in the molecular structure. However, in common organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc., it shows good solubility. This characteristic is due to the principle of "similar compatibility". The molecular structure of the organic solvent has a certain similarity to the structure of the compound, which can form intermolecular forces and promote dissolution.
In terms of melting point, it has been experimentally determined to be about a specific temperature range, which is of great significance for the identification and purity judgment of the compound. The melting point is relatively fixed. If the melting point of the sample deviates greatly from the literature value, it may mean that the purity is insufficient or contains impurities. < Br >
Density is also one of its important physical properties. Under established conditions, it has a specific density value, which has a certain impact on its separation, purification and behavior in related chemical reaction systems.
The physical properties of this compound provide a basic basis for its application in many fields such as organic synthesis and drug development.

To prepare 5- (1H-pyrrole-4-yl) pyrimidine-2-carboxylic acid, the following ancient method can be used.
First, appropriate starting materials are taken, and pyrrole and pyrimidine-related derivatives are used as the basis. Usually, 4-halo-1H-pyrrole and 2-halo pyrimidine are used as the starting point. In a suitable reaction environment, the 4-position of pyrrole is connected to the 5-position of pyrimidine by palladium-catalyzed coupling. The palladium catalyst used, such as tetra (triphenylphosphine) palladium, needs to be used in an appropriate amount, and the reaction solvent should be selected from a polar aprotic solvent, such as N, N-dimethylformamide (DMF), etc. The reaction temperature also needs to be precisely controlled. It is often heated moderately, between about 80 and 120 degrees Celsius, and after several hours, the coupling reaction can be fully carried out.
The product to be coupled is obtained, followed by the step of carboxylation. Carbon dioxide is often used as the source of carboxyl groups, and in an alkaline environment, the 2-position of pyrimidine is introduced into the carboxyl group. The alkali used, such as potassium carbonate, sodium carbonate, etc., carbon dioxide can be introduced into the autoclave at an appropriate pressure, and the reaction temperature needs to be adjusted, usually between room temperature and 50 degrees Celsius. When the number of reactions is reached, the crude product of 5- (1H-pyrrole-4-yl) pyrimidine-2-carboxylic acid can be obtained through this step.
The crude product still needs to be refined, and the method of recrystallization is appropriate. Select an appropriate solvent, such as a mixed solvent of ethanol and water, and dissolve it by heating, cooling, crystallization, filtration, drying, etc., to obtain a pure 5- (1H-pyrrole-4-yl) pyrimidine-2-carboxylic acid product. The whole process requires fine operation, and the reaction conditions at each step need to be carefully controlled in order to achieve satisfactory yield and purity.

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There are many derivatives related to 5- (1H-pyrrole-4-yl) uracil-2-carboxylic acids.
In the field of heterocyclic chemistry, this structure is quite unique. Its pyrrole ring is connected to the uracil ring, and the carboxylic acid group at the 2-position can undergo various reactions. Such as esterification, the carboxylic acid and alcohol are dehydrated and condensed under acid catalysis to obtain corresponding ester derivatives. In this process, concentrated sulfuric acid is used as the catalyst, and heating conditions can promote the reaction to the right. The resulting ester derivatives may have potential applications in drug delivery systems because they can change the solubility and lipid solubility of the original compound, which is conducive to drug penetration through biofilms.
The amidation reaction is also an important path. Under the action of condensing agents, carboxylic acids and amine compounds can form amide bonds and generate amide derivatives. Commonly used condensing agents such as dicyclohexyl carbodiimide (DCC) can activate carboxylic acids and promote their reaction with amines. Amide derivatives may play a key role in the construction of bioactive molecular frameworks. Amide bonds are stable and can participate in intermolecular hydrogen bonds, which affect the biological activity of compounds.
In addition, carboxyl groups can also be converted into alcohol hydroxyl groups through reduction reactions. Derivatives containing alcohol hydroxyl groups can be obtained by reacting in suitable solvents with sodium borohydride as reducing agents. Such derivatives may serve as key intermediates in the synthesis of complex natural product analogs, providing diverse possibilities for subsequent functional group transformation. They can further introduce other groups to expand the structural diversity of compounds and explore more potential biological activities.