4-methoxy-1-benzothiophene-2-carboxylic acid

4-Methoxy-1-benzothiophene-2-carboxylic acid, which has a wide range of uses. In the field of medicinal chemistry, it is a key organic synthesis intermediate and often appears in many drug research and development processes. The molecular structure of Gein is unique, containing benzothiophene and carboxyl groups. The structure of benzothiophene has good biological activity and drug affinity, and the carboxyl group can participate in a variety of chemical reactions to help build drug active structures. For example, when developing anti-tumor drugs, using this as a raw material, through a series of reactions, compounds can be synthesized that have inhibitory effects on tumor cells. By modifying its structure, drug efficacy and targeting can be optimized.
In the field of materials science, it also has extraordinary performance. It can be used to prepare special functional organic materials, such as photoelectric materials. Due to the conjugated system in the structure, the conjugated structure endows the material with unique photoelectric properties, and can produce special electrical and optical responses under the action of light or electric field. By chemically modifying and processing it, organic Light Emitting Diode (OLED), solar cells and other device materials can be prepared to improve device performance and efficiency.
In addition, in the field of fine chemicals, 4-methoxy-1-benzothiophene-2-carboxylic acids can be used as raw materials for the preparation of fine chemicals such as special fragrances and dyes. After specific chemical reactions, it can endow fragrances with unique odor or add excellent dyeing properties and color stability to dyes. Due to its structural particularity, it can play a unique role in fine chemical products, meeting the needs of different industries for specialized chemicals.

4-Methoxy-1-benzothiophene-2-carboxylic acid, this substance is in the state of white to off-white crystalline powder. Its melting point is quite important, about 192-196 ° C. This property can be used for the identification and purity judgment of substances. Because the melting point range is relatively fixed, if the sample melting point deviates from this range, it may suggest that the purity is questionable.
When it comes to solubility, it shows different properties in common organic solvents. In organic solvents such as dichloromethane, N, N-dimethylformamide, it has a certain solubility, which is of great significance in the selection of solvents for organic synthesis reactions, allowing the reactants to be fully mixed and promoting the smooth progress of the reaction. However, its solubility in water is poor, which is due to the strong hydrophobicity of benzothiophene ring and methoxy group in the molecular structure, which makes it difficult to dissolve in water with strong polarity.
From the perspective of stability, under conventional temperature and humidity conditions, 4-methoxy-1-benzothiophene-2-carboxylic acid can remain relatively stable. However, it should be noted that it is more sensitive to the environment of strong acids and bases. When encountering strong acids, methoxy groups in the molecule may undergo reactions such as protonation, thereby changing the molecular structure; when encountering strong bases, carboxylic groups are easily neutralized with bases to form corresponding carboxylic salts, which in turn affect their chemical properties and applications.
In addition, the substance has a certain degree of hygroscopicity. In a high humidity environment, it may absorb moisture in the air. Although a small amount of hygroscopicity has limited impact on its chemical properties, excessive hygroscopicity or agglomeration will affect subsequent use. Therefore, attention should be paid to controlling the ambient humidity when storing. These physical properties play a key guiding role in its storage, transportation, and application in organic synthesis, drug development, and other fields.

The synthesis method of 4-methoxy-1-benzothiophene-2-carboxylic acid is described in many ancient books. Common ones include benzothiophene as the starting material and obtained by multi-step reaction.
In the first step, benzothiophene is often methoxylated. In this case, a suitable base, such as sodium hydride, can be selected to make benzothiophene and methylation reagents, such as dimethyl sulfate, in a suitable solvent, such as N, N-dimethylformamide (DMF), react under specific temperature conditions to obtain 4-methoxy-1-benzothiophene. This step requires careful temperature control and attention to the material ratio to prevent side reactions.
In the next step, the resulting 4-methoxy-1-benzothiophene is further carboxylated. The method commonly used in this step is to use carbon dioxide as the carboxyl source and react in ether solvents such as tetrahydrofuran (THF) under the catalysis of metal catalysts such as magnesium or lithium. During the reaction, it is necessary to ensure that the system is anhydrous and oxygen-free, because moisture and oxygen will interfere with the reaction process and reduce the yield. < Br >
Another method can be used to construct the structure of 4-methoxy-1-benzothiophene-2-carboxylic acid through cyclization and substitution from raw materials containing sulfur and benzene rings. For example, o-halothiophenol and alkenyl compounds containing methoxy and carboxyl precursors are used as raw materials and are cyclized under the catalysis of transition metals such as palladium. In this process, the activity of metal catalysts and the selection of ligands are crucial, which have a significant impact on the selectivity and yield of the reaction.
Or, the synthesis route can be optimized by adjusting the reaction conditions and the reagents used to improve the purity and yield of the product. Such as changing the reaction temperature and time, changing the solvent or catalyst may have a significant impact on the reaction result. The synthesis path is diverse, and the appropriate method needs to be carefully selected according to the actual needs and conditions of raw materials and equipment.

What you are asking is what the price of 4-methoxy-1-benzothiophene-2-carboxylic acid is in the market. However, this is not an easy question to answer. The price in the market often changes for many reasons.
Looking at the past "Tiangong Kaiwu", the price of all things is related to the place of origin, season, supply and demand. For 4-methoxy-1-benzothiophene-2-carboxylic acid, its origin is different, and the price is different. If it is produced in a prosperous place, the raw materials are easily available, and the labor is convenient, the price may be slightly cheaper; if it is remote and difficult to harvest and transport, the price will increase. The
season is also the main reason. If the demand for it increases sharply at a certain time, such as the pharmaceutical industry needs it urgently, and the producer fails to respond quickly, the price will rise; on the contrary, if there is no big demand, the producer will stock up and the price may drop.
And this compound is often used in specialized fields such as scientific research and pharmaceuticals, and its purity requirements are quite high. For high purity, it is difficult to prepare and the price is high; for slightly lower purity, the price may be slightly lower.
Today in the market, I have not seen its detailed price in person. However, if you want to know its approximate, you can consult the chemical raw material supplier, reagent supplier, or check it on the chemical product trading platform to get a more accurate price.

4-Methoxy-1-benzothiophene-2-carboxylic acid, which is an important organic compound in fine chemicals. Its storage conditions are crucial, which is related to the stability and quality of the compound.
It is advisable to store it in a cool and dry place. Because the compound is prone to molecular structure changes at high temperature, its properties are damaged. And humid environments can easily cause deliquescence and other conditions, destroying its chemical purity.
The place where it is stored should ensure good ventilation. If the ventilation is poor, its volatile gases will accumulate, which may not only affect the surrounding environment, but even pose a safety hazard due to high concentration.
Be sure to store it separately from oxidizing substances and alkaline substances. 4-methoxy-1-benzothiophene-2-carboxylic acid has specific chemical activity, contact with oxidizing substances, or cause violent oxidation reactions, causing combustion or even explosion; encounter with alkaline substances, or chemical reactions such as acid-base neutralization, change its chemical properties.
In terms of packaging, well-sealed packaging materials should be used. Common such as glass bottles, plastic bottles, etc., sealed packaging can effectively isolate air and moisture and delay its deterioration. And the name, characteristics and storage precautions of the compound should be clearly marked on the outside of the package. < Br >
In the process of taking, it is also necessary to operate with caution to shorten the exposure time to the external environment as much as possible. After taking it, seal it immediately and put it back in the original storage place. In this way, the quality and stability of 4-methoxy-1-benzothiophene-2-carboxylic acid can be effectively guaranteed, so that it can play its due role in subsequent use.