4-Bromothiophene-2-carboxaldehyde

4-Bromothiophene-2-formaldehyde is a crucial chemical substance in the field of organic synthesis. It has a wide range of uses and is first applied in drug synthesis. In the process of many drug research and development, 4-bromothiophene-2-formaldehyde acts as a key intermediate, which can be cleverly spliced with other compounds through a series of organic reactions to construct molecular structures with specific pharmacological activities. For example, in the creation of some antibacterial drugs, using this as the starting material can successfully prepare new drug molecules that have significant inhibitory effects on specific bacteria through reaction steps such as halogenation, condensation, and cyclization.
Furthermore, in the field of materials science, 4-bromothiophene-2-formaldehyde also plays an important role. It can be used to synthesize organic materials with special optoelectronic properties. By connecting with conjugated structural units, materials can be prepared that perform well in optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells. Due to the unique electronic structure of thiophene rings and bromine atoms, the synthesized materials exhibit excellent charge transport and light absorption properties, which in turn enhance the performance of optoelectronic devices.
In addition, in the preparation of fine chemicals, 4-bromothiophene-2-formaldehyde is an important raw material for the synthesis of a variety of functional fine chemicals. Such as special fragrances, pigments, etc. Through appropriate chemical modification, these fine chemicals are endowed with unique odor, color or other physical and chemical properties to meet the needs of different industries for special chemicals.

The synthesis of 4-bromothiophene-2-formaldehyde has always been a key issue in organic synthesis. Common synthesis paths are as follows:
First, thiophene is used as the initial raw material. Schilling thiophene is brominated. This reaction is usually carried out under low temperature or light conditions in a suitable solvent such as dichloromethane. After bromination, 4-bromothiophene can be obtained. Then, 4-bromothiophene and suitable reagents, such as N, N-dimethylformamide (DMF) and phosphorus oxychloride (POCl), can be introduced into the 2-position of the thiophene ring through the Vilsmeier-Haack reaction, and the final result is 4-bromothiophene-2-formaldehyde. This path step is slightly simpler, but the reaction conditions need to be precisely controlled, and the reagents used may be toxic and corrosive, and the operation should be cautious.
Second, it starts with 2-thiophenaldehyde. 2-Thiophene formaldehyde is brominated with a suitable brominating reagent, such as liquid bromine, and in the presence of a suitable catalyst, such as iron powder or iron tribromide. In this process, the formyl group is an ortho-and para-locator, which can guide the bromine atom mainly into the 4-position, so as to obtain the target product 4-bromothiophene-2-formaldehyde. The advantage of this method is that the starting material is relatively easy to obtain, but the selective control of the bromination step may be difficult, and the occurrence of side reactions needs to be paid attention to.
Third, other compounds containing thiophene structures are also used as starting materials, and the target molecule is constructed through multi-step reaction. For example, thiophene derivatives containing suitable substituents are prepared first, and then bromine atoms and formyl groups are gradually introduced through functional group transformation. Although this strategy has many steps, under certain circumstances, the characteristics of raw materials can be used to improve the selectivity and yield of synthesis.
In short, the synthesis of 4-bromothiophene-2-formaldehyde needs to be based on the actual situation, weighing the availability of raw materials, reaction conditions, cost and yield, and carefully selecting the appropriate synthesis method.

4-Bromothiophene-2-formaldehyde, which is colorless to pale yellow liquid or crystalline, is relatively stable at room temperature and pressure. Its melting point is between 28-32 ° C, and its boiling point is 238-240 ° C. The density is about 1.72 g/cm ³, and the refractive index (n20/D) is about 1.625.
Its solubility is quite unique, slightly soluble in water, but it can be well miscible with common organic solvents such as ethanol, ethyl ether, and dichloromethane. Because it contains both bromine atoms and aldehyde groups in its molecules, it is very chemically active. Bromine atoms can participate in substitution reactions, such as nucleophilic substitution, and can be replaced by many nucleophilic reagents. The aldehyde group can undergo many reactions, such as oxidation reactions to form carboxylic acids, reduction reactions to form alcohols, and condensation reactions with nucleophiles such as nitrogen and sulfur.
For storage, it needs to be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its sensitivity to air and humidity, it should be sealed and stored to prevent deterioration and affect its chemical properties and application.

4-Bromothiophene-2-formaldehyde is a key compound in the field of organic synthesis. Its chemical properties are unique and have far-reaching effects on many organic reactions.
In terms of its physical properties, 4-bromothiophene-2-formaldehyde is often in solid form and exhibits a certain solubility in specific organic solvents, such as common ethanol, ether, etc. This property is convenient for it to disperse and participate in reactions in organic synthesis reaction systems.
In terms of chemical properties, its aldehyde group activity is quite high. The aldehyde group is an extremely active functional group and can participate in many classical reactions. One is the acetalization reaction with alcohols. Under the action of an acidic catalyst, the aldehyde group condenses with the alcohol hydroxyl group to form an acetal structure. This reaction is often used in organic synthesis to protect the aldehyde group from unnecessary participation in other subsequent reactions. After the desired reaction is completed, the acetal is hydrolyzed under specific conditions to re-release the aldehyde group.
Second, the aldehyde group can undergo oxidation reaction. Under the action of an appropriate oxidant, the aldehyde group can be oxidized to a carboxyl group to generate 4-bromothiophene-2-carboxylic acid. Commonly used oxidants include strong oxidants such as potassium permanganate and potassium dichromate, but such oxidants have strong oxidizing properties, and the reaction conditions need to be carefully controlled, otherwise it is easy to cause excessive oxidation. There are also relatively mild oxidants, such as silver ammonia solution and new copper hydroxide suspension, which can realize the conversion of aldehyde groups to carboxyl groups under relatively mild conditions. Such reactions are often used for qualitative testing of aldehyde groups and oxidation preparation under specific conditions.
Third, the bromine atom of 4-bromothiophene-2-formaldehyde is also quite active. The bromine atom is attached to the thiophene ring, and the electron cloud distribution of the thiophene ring makes the bromine atom prone to substitution reactions. In the presence of nucleophiles, bromine atoms can be replaced by nucleophiles to form new carbon-heteroatomic bonds. For example, when reacted with amine nucleophiles, nitrogen-containing substitution products can be formed, which enriches the application of this compound in constructing complex organic molecular structures.
In addition, the thiophene ring of 4-bromothiophene-2-formaldehyde itself has aromatic properties and can participate in some aromatic ring-based reactions, such as the Fu-gram reaction, so as to modify the thiophene ring and expand the variety and application scope of its derived compounds.

The price range of 4-bromothiophene-2-formaldehyde in the market is difficult to determine. The price of the cover often changes for many reasons.
The supply and demand of the city is the main reason for the change in price. If there are many people who want it, but there are few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price may fall.
Furthermore, the cost of producing this product is also related to its price. The price of raw materials, the process of making it, labor costs and transportation resources can all cause changes in costs, which in turn affects the price of the market.
Also, the quality is also related to the price. The better, the price may be high; the lower the quality, the lower the price.
According to past market conditions, the price may fluctuate from a few yuan to tens of yuan per gram. However, this is only an approximate number, and the actual price depends on the current market situation, purchase quantity and supplier pricing. To know the exact price, you can consult the chemical material supplier, or visit the chemical product trading platform to get real-time price information.