4-BROMO-3-METHYLTHIOPHENECARBOXYLIC ACID

4-Bromo-3-methylthiophene-carboxylic acid, this is an organic compound. It has a wide range of uses and is of great significance in the field of organic synthesis.
First, it can be used as an intermediate in organic synthesis. With its special structure, it can participate in many chemical reactions, thereby constructing more complex organic molecules. For example, when building a drug molecule containing a specific thiophene structure, 4-bromo-3-methylthiophene-carboxylic acid is often used as the starting material, and the activity of bromine atom and carboxyl group is used to gradually introduce other functional groups through halogenation reaction, esterification reaction, amidation reaction, etc., to achieve the synthesis of the target product.
Second, it is also useful in the field of materials science. Thiophene compounds have unique electrical and optical properties due to their conjugated structures. 4-Bromo-3-methylthiophene-carboxylic acids can be chemically modified for the preparation of conductive polymers, photoelectric materials, etc. For example, by polymerization with other monomers, materials with specific electrical conductivity or optical properties can be prepared, which can be used in organic Light Emitting Diodes (OLEDs), solar cells and other devices.
Third, in pharmaceutical chemistry research, as a key intermediate, many bioactive compounds can be derived. By modifying its structure, changing the types and positions of substituents, studying the biological activities of different derivatives, screening potential drug lead compounds, and laying the foundation for the development of new drugs.
In summary, 4-bromo-3-methylthiophene-carboxylic acids play an important role in organic synthesis, materials science and drug development, and promote the progress and development of related fields.

4-Bromo-3-methylthiophene carboxylic acid, this is an organic compound. Its physical properties, let me go one by one.
Looking at its appearance, under room temperature and pressure, it often takes the shape of white to off-white crystalline powder, which is easy to observe and handle. Its melting point is about 185-189 ° C, and the melting point is fixed. This is an important physical property, which can help to distinguish and purify.
In terms of solubility, it has a certain solubility in organic solvents, such as dichloromethane, N, N-dimethylformamide, etc. In dichloromethane, due to its similar miscibility principle, it is partially soluble and can form a uniform dispersion system; in N, N-dimethylformamide, it has better solubility. This characteristic is often used as a solvent in organic synthesis reactions to help the reactants fully contact and speed up the reaction process.
However, in water, the solubility is very small. Water is a polar solvent, and although there are carboxyl groups in the structure of this compound that can form hydrogen bonds with water, the hydrophobicity of thiophene ring and bromine, methyl and other groups is dominant, resulting in the whole being insoluble in water.
In addition, its density, boiling point, etc., although there are no accurate common reports, but according to its structure and the law of similar compounds, the density should be slightly higher than that of water, and the boiling point or due to intermolecular forces, it is relatively high. Its stability is still good. Under normal temperature and pressure, without the influence of special chemical reagents or conditions, the structure is not easy to change and can be stored for a long time. However, under extreme conditions such as strong oxidation and strong reduction, the structure may be damaged and chemical reactions occur.

The synthesis method of 4-bromo-3-methylthiophene-2-carboxylic acid (4-BROMO-3-METHYLTHIOPHENECARBOXYLIC ACID), although the ancient book "Tiangong Kaiwu" does not contain the synthesis method of this substance, according to the principle of chemical synthesis today, it can be prepared by the following way.
First, 3-methylthiophene is used as the starting material, because there are active hydrogen atoms on the thiophene ring, which can undergo electrophilic substitution reaction with bromine. Under suitable reaction conditions, such as carbon tetrachloride as a solvent, and an appropriate amount of bromine at low temperature and in the presence of a catalyst (such as iron powder or iron tribromide), bromine preferentially replaces the hydrogen atom at the 2-position of the thiophene ring (relative to the 4-position of 3-methyl) to generate 4-bromo-3-methylthiophene. This step requires strict control of the reaction temperature and the amount of bromine to avoid excessive bromination.
Then, the obtained 4-bromo-3-methylthiophene is carboxylated. The format reagent method can be selected, that is, 4-bromo-3-methylthiophene reacts with metal magnesium in anhydrous ether and other inert solvents to generate the corresponding Grignard reagent 4-bromo-3-methylthiophene magnesium. After that, carbon dioxide gas is introduced into the system, and the Grignard reagent undergoes nucleophilic addition reaction with carbon dioxide to generate carboxylate intermediates. Finally, the target product 4-bromo-3-methylthiophene-2-carboxylic acid can be obtained by acidification with dilute acid (such as hydrochloric acid). < Br >
There are also other synthesis methods, such as using suitable compounds containing carboxyl groups, bromine and methyl substituents as raw materials, and constructing thiophene rings through cyclization. However, precise control of the reaction conditions is required to ensure that each substituent is in the target position when the thiophene ring is formed. In short, the synthesis of this compound requires careful design of the reaction steps and strict control of the reaction conditions of each step to obtain a product with higher yield and purity.

I look at this question, but I am inquiring about the price range of 4-bromo-3-methylthiophenecarboxylic acid in the market. However, the price of this compound often varies due to many factors, and it is difficult to hide it.
First, the source of the goods has a great impact. If it is a well-known large factory refined product, the quality is high, and the price may be high; while the small factory produces it, although the price may be low, the quality may be inferior. Second, the quantity is also the key. The purchase volume is very large, and the merchant may give a discount in order to promote the sale, and the price must be lower than that of a small purchase. Furthermore, the market supply and demand situation determines the price. If the demand for this product is strong and the supply is scarce, the price will rise; conversely, if the supply exceeds the demand, the price will decline.
According to past market conditions and market rules, it is speculated that the price per gram for small purchases may be between tens and hundreds of yuan. If you buy in bulk, the price per gram may drop to a few yuan to a few tens of yuan. However, this is only speculation. The actual price should be consulted in detail with chemical reagent suppliers, chemical raw material trading platforms, etc., subject to real-time quotations. The market is ever-changing, and the price is also impermanent. If you want to know the exact price, you must personally search for it to get an accurate number.

4-Bromo-3-methylthiophene carboxylic acid, this is an organic compound. Its storage conditions are crucial, related to its quality and stability.
Store in a cool place, this is the first priority. Due to high temperature, the compound is prone to thermal decomposition and other reactions, which damage its structure and properties. In a cool place, the temperature is low, which can slow down the thermal movement of molecules and reduce the probability of reaction.
A dry environment is also indispensable. Water vapor in the air can interact with the compound, or cause adverse changes such as hydrolysis. Therefore, it needs to be stored in a dry place, such as a sealed container, which can hold a desiccant to keep the environment dry.
Furthermore, it should be avoided from contact with oxidants. The structure of 4-bromo-3-methylthiophene carboxylic acid contains specific functional groups, which may cause fire and explosion in case of oxidizing agent or severe oxidation reaction. When storing, be sure to place it separately from the oxidizing agent, and the storage area should be clearly marked to prevent accidental mixing.
Keep away from fire and heat sources. This compound is flammable to a certain extent, in case of open flame, hot topic, or ignition or even explosion. The storage place should be free of fire sources, and electrical equipment should be explosion-proof to ensure safety.
The choice of storage containers is also exquisite. Corrosion-resistant materials should be used. Due to compounds or reactions with certain materials, the container will be damaged and leaked. Common such as glass or specific plastic containers, with good sealing and corrosion resistance, can be effectively stored.
Handle with care when handling. Because it may be more sensitive, it may be hit, vibrated, or cause a reaction. Staff should be professionally trained and operate according to specifications to ensure the safety and stability of the compound during storage and handling.