4-bromo-2-Thiophenecarbonitrile

4-Bromo-2-thiophenoformonitrile is an important intermediate in organic synthesis. It has a wide range of uses and is mostly a key raw material for the creation of new drugs in the field of medicinal chemistry. The unique structure of the thiophene ring with cyano and bromine atoms endows it with various reactive activities, and compounds with specific pharmacological activities can be constructed through many chemical reactions. For example, it can introduce different functional groups through nucleophilic substitution reactions to meet the interaction requirements of drugs and targets, and help to develop antibacterial, anti-cancer and other drugs.
is also highly valued in the field of materials science. It can be used as a basic unit for building functional materials, and materials with specific optoelectronic properties can be prepared through rational molecular design and synthesis strategies. For example, by connecting with conjugated structural units, organic semiconductor materials are prepared and applied to optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic field effect transistors (OFETs) to improve device performance.
In addition, in the field of pesticide chemistry, 4-bromo-2-thiophenoformonitrile is also useful. It can be chemically modified to create new pesticides with high efficiency, low toxicity and environmental friendliness, providing a powerful means for crop pest control. Because thiophene derivatives often have unique biological activities, and bromine atoms and cyanos can optimize molecular lipophilicity, electron cloud distribution and other properties, enhance their inhibition and killing ability against pests and pathogens.

4-Bromo-2-thiophenoformonitrile is also an important intermediate in organic synthesis. There are many ways to synthesize it.
One is obtained by bromination with 2-thiophenoformonitrile as the starting material. Among them, N-bromosuccinimide (NBS) can be used as the bromine source in an appropriate solvent, such as dichloromethane and chloroform, in the presence of an initiator such as benzoyl peroxide (BPO), heated or illuminated to initiate a free radical bromination reaction. In this process, NBS provides bromine free radicals and attacks the 4-position of the thiophene ring to obtain the target product. The key to the reaction is to control the reaction temperature, the amount of bromine source and the reaction time to prevent the formation of polybrominated by-products.
Second, 4-bromo-2-halothiophene can also be prepared by reacting with a cyanide reagent. For example, 4-bromo-2-chlorothiophene with sodium cyanide or potassium cyanide is reacted in a polar aprotic solvent such as N, N-dimethylformamide (DMF) and dimethyl sulfoxide (DMSO) at an appropriate temperature. This nucleophilic substitution reaction reacts with a cyano group replacing a halogen atom to obtain 4-bromo-2-thiophenylcarbamonitrile. This method requires attention to the toxicity of cyanide reagents. When operating, it should be well ventilated, and the reaction conditions should be strictly controlled to ensure the smooth progress of the reaction and reduce side reactions.
Or you can start from thiophene, first brominate, introduce bromine atoms at the 4-position, and then introduce cyanyl groups. First brominate thiophene with bromine or other brominating agents to obtain 4-bromothiophene, and then undergo a series of reactions, such as reacting with cyanide halide or cyanide reagents under suitable conditions, introducing cyanide groups, and finally obtaining the target compound. This route is slightly complicated, but the raw materials are easy to obtain. If the reaction conditions of each step are properly controlled, higher yield products can also be obtained.

4-Bromo-2-thiophenylformonitrile is one of the organic compounds. Its physical properties are particularly important and are fundamental to many chemical applications.
First of all, its appearance, 4-bromo-2-thiophenylformonitrile is often white to light yellow crystalline powder, with fine particles and pure color. This appearance is very important for identifying and preliminarily judging its quality.
As for the melting point, it is between 92 ° C and 96 ° C. The melting point is the critical temperature at which the substance changes from solid to liquid. This property is stable and can be an important basis for purity identification. If its melting point deviates from this range, or implies that there are other substances in it, the purity is not ideal.
Furthermore, solubility is also an important physical property. 4-Bromo-2-thiophenylformonitrile is soluble in common organic solvents, such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), etc. In dichloromethane, it can quickly disperse and dissolve to form a uniform solution. Due to the adaptation of the forces between the two molecules, it is conducive to interpolation and mixing. However, in water, its solubility is very small, and its molecular structure lacks groups that strongly interact with water molecules, so it is difficult to dissolve in water.
In addition, the density of 4-bromo-2-thiophenylformonitrile is also fixed. Although the exact value needs to be determined accurately according to the experiment, its density is higher than that of water. This characteristic can be considered when it involves liquid-liquid separation and other operations to clarify its location distribution in the system.
In summary, the physical properties of 4-bromo-2-thiophenylformonitrile, from appearance, melting point, solubility to density, are the key elements for understanding this compound. They are of great value in many fields such as organic synthesis and drug development. They can help chemists understand their characteristics and make good use of them to become various chemical targets.

4-Bromo-2-Thiophenecarbonitrile, Chinese name 4-bromo-2-thiophenoformonitrile, its market price often fluctuates due to a variety of reasons, and it is difficult to generalize.
Looking at the state of the market in the past, the price of this compound is affected by various factors such as the amount of raw materials, the difficulty of preparation, and the urgency of demand. If the raw materials required for preparation are abundant and the refining method is simple, the price may stabilize or even decline; on the contrary, if the raw materials are scarce and the preparation process is complicated, the price will rise.
Furthermore, changes in market demand also have a significant impact on its price. If the demand for 4-bromo-2-thiophenoformonitrile increases sharply in many industries at a certain time, the supply will exceed the demand, and the price will rise; if the demand is sluggish and the supply exceeds the demand, the price will fall.
Also, different suppliers sell this compound at different prices due to differences in production scale, technical level, and operating costs. Large suppliers, with the benefit of scale, may have lower costs, and the price may be relatively close to the people; while small suppliers, with higher costs, may have relatively high prices.
And the market price also changes over time, sometimes due to the discovery of new raw material sources, the advent of new technologies, and sometimes due to economic trends and changes in policies and regulations. Therefore, to know the exact market price, you need to carefully check the current market information, consult multiple suppliers, and compare prices to obtain a more accurate figure.

4-Bromo-2-thiophenoformonitrile is an organic compound. When storing and transporting, the following things must be paid attention to:
First, the storage environment should be dry and cool. This compound is afraid of moisture, and humid environments are prone to deterioration, so it should be placed in a dry place to prevent contact with water vapor. A cool environment can reduce the risk of reaction caused by excessive temperature. Usually, the storage temperature should be controlled at 2-8 ° C.
Second, it needs to be sealed and stored. Because it is volatile and may react with oxygen, carbon dioxide and other components in the air, sealing can prevent it from contacting with external gases to ensure its chemical stability. You can choose a suitable sealed container, such as a glass bottle with a sealing plug, or a sealed plastic container.
Third, ensure that the packaging is stable during transportation. 4-Bromo-2-thiophenoformonitrile may be dangerous in the bumpy vibration, so the packaging must be tight and can be filled with buffer materials, such as foam, cotton, etc., to prevent the container from being damaged during transportation and causing it to leak.
Fourth, it should be avoided to mix and transport with oxidizing agents, acids, alkalis and other substances. This compound is chemically active, and contact with the above substances or react violently, causing serious consequences such as combustion and explosion.
Fifth, the storage and transportation places should be equipped with corresponding emergency treatment equipment and protective equipment. If there is an accident such as leakage, it can be dealt with in time. For example, with adsorption materials to handle leaked liquids, staff should also be equipped with protective gloves, goggles, and gas masks to ensure their personal safety.