4-Bromo-2-thiophene carboxaldehyde

4-Bromo-2-thiophenylformaldehyde, an important raw material in organic synthesis, is widely used in many fields.
In the field of medicinal chemistry, it can be used as a key intermediate to synthesize various drugs. For example, through specific chemical reactions, it can be converted into compounds with unique pharmacological activities for the development of antibacterial, anti-inflammatory and anti-tumor drugs. The thiophene ring, bromine atom and aldehyde group in its structure endow the compound with unique reactivity and spatial structure, which can participate in a variety of organic reactions and help to construct complex drug molecular structures.
In the field of materials science, 4-bromo-2-thiophenylformaldehyde is also of great value. It can participate in the preparation of functional materials, such as organic optoelectronic materials. In studies such as organic Light Emitting Diode (OLED) and organic solar cells, this compound can be appropriately modified and polymerized to construct polymers or small molecule materials with specific optoelectronic properties, which is of great significance for improving the performance of materials such as charge transfer efficiency and luminous efficiency.
In the field of fine chemistry, it is often used to synthesize high-value-added fine chemicals. For example, as a starting material, a series of reactions can be used to synthesize special structures such as fragrances and dyes. Due to its unique chemical structure, it can bring unique color, odor and other characteristics to the synthetic products, meeting the special needs of different industries for fine chemicals.
In addition, in the field of academic research, 4-bromo-2-thiophenaldehyde is also a commonly used reagent in organic chemistry research. By studying the chemical reactions it participates in, researchers explore new reaction mechanisms and synthesis methods, providing theoretical support and practical experience for the development of organic synthetic chemistry.
In summary, 4-bromo-2-thiophenylformaldehyde, with its unique chemical structure and reactivity, plays an indispensable role in many fields such as medicine, materials, fine chemicals, and academic research, and is of great significance for promoting technological progress and innovation in various fields.

The synthesis method of 4-bromo-2-thiophene formaldehyde has had its own advantages and disadvantages throughout the ages. First, it can be obtained from 2-thiophene formaldehyde and obtained by bromination. In a suitable reaction vessel, dissolve 2-thiophene formaldehyde in a suitable solvent, such as glacial acetic acid, and slowly add brominating reagents, such as bromine, to control the reaction temperature, usually at a low temperature, about 0-5 ° C, to prevent excessive bromination. In the meantime, close attention should be paid to the reaction process, which can be monitored by thin-layer chromatography. After the reaction is completed, after post-treatment, such as extraction, washing, drying, distillation, etc., pure 4-bromo-2-thiophene formaldehyde can be obtained.
Second, 4-bromo-2-thiophene is used as raw material and prepared by formylation reaction. Combine 4-bromo-2-thiophene with suitable formylating agents, such as N, N-dimethylformamide (DMF) and phosphorus oxychloride (POCl). Mix 4-bromo-2-thiophene with DMF, cool to a certain temperature, such as 0-10 ° C, add POCl dropwise, then heat to a suitable temperature, such as 60-80 ° C, and react. After the reaction is completed, it is hydrolyzed in ice water, neutralized in alkali solution, followed by extraction, separation, purification and other processes to obtain the target product.
Third, starting from thiophene, it is constructed by multi-step reaction. First, thiophene is brominated to obtain 4-bromothiophene, and then an aldehyde group is introduced through specific group protection and formylation, and then deprotected. After multi-step fine operation, although the process is complicated, it is also one way to synthesize 4-bromo-2-thiophene formaldehyde. Each method has its advantages and disadvantages, and the experimenter needs to weigh and choose according to actual demand, raw material availability, cost and many other factors.

4-Bromo-2-thiophene formaldehyde is one of the organic compounds. It has specific physical properties. Looking at its morphology, under room temperature and pressure, it is mostly a light yellow to yellow crystalline powder, which is easy to observe and operate.
When it comes to the melting point, it is about 61-65 ° C. The melting point is the temperature limit for the transformation of a substance from a solid state to a liquid state. This specific melting point range is crucial for the identification and purity determination of compounds. Due to the different purity of 4-bromo-2-thiophene formaldehyde, its melting point may be slightly different.
In addition to solubility, it is slightly soluble in water. Water is the source of all things and the solvent of many substances. However, the degree of solubility of this compound in water is limited due to the characteristics of its molecular structure. Some of its molecular structures interact weakly with water molecules, so it is slightly soluble. However, it has good solubility in organic solvents, such as ethanol and dichloromethane. The molecular structure of organic solvents is more compatible with 4-bromo-2-thiophenaldehyde, and the intermolecular force is appropriate, which promotes its better dispersion in it. This solubility characteristic is widely used in the separation and purification steps of organic synthesis.
In addition, 4-bromo-2-thiophenaldehyde has a certain volatility. Although not highly volatile, some molecules can escape into the air under certain conditions, such as when heated and placed in a ventilated place. This volatility should also be taken into account during storage and use to prevent loss and impact on the environment.

4-Bromo-2-thiophene formaldehyde, an organic compound, has unique chemical properties and is widely used in the field of organic synthesis.
The presence of aldehyde groups gives it significant chemical activity. The aldehyde group has strong reductivity and can react with many oxidants. In case of weak oxidants, such as Torun reagent (silver ammonia solution), a silver mirror reaction will occur. The aldehyde group is oxidized to carboxyl groups, and metallic silver is precipitated at the same time, forming a bright silver mirror on the wall of the test tube. In case of Feilin reagent, a reaction will also occur, and the aldehyde group is oxidized to form a brick-red cuprous oxide precipitate.
Furthermore, the aldehyde group can participate in nucleophilic addition reactions. Common nucleophilic reagents, such as alcohols, can react with the aldehyde group of 4-bromo-2-thiophene formaldehyde under the action of acidic or basic catalysts to generate hemiacetals, which in turn generate acetals. This reaction is often used in organic synthesis to protect the aldehyde group from being affected in subsequent reactions.
The bromine atom in the molecule of 4-bromo-2-thiophene formaldehyde also has active chemical properties. The bromine atom can undergo a substitution reaction. Under suitable reaction conditions, such as in an alkaline environment or in the presence of a specific catalyst, the bromine atom can be replaced by other nucleophilic reagents, such as hydroxyl groups, amino groups, etc., to synthesize organic compounds with more complex structures.
In addition, 4-bromo-2-thiophenaldehyde can also undergo some reactions related to the thiophene ring. Although the thiophene ring has certain aromatic properties, compared with the benzene ring, the electron cloud distribution on the thiophene ring is uneven, which makes the substitution reaction on the thiophene ring unique. Under specific conditions, other substituents can be introduced into the thiophene ring to further modify and modify the molecular structure to meet the needs of different organic synthesis. In short, 4-bromo-2-thiophenaldehyde exhibits diverse and important chemical properties in the field of organic synthesis chemistry due to its aldehyde group, bromine atom and thiophene ring.

4-Bromo-2-thiophene formaldehyde, the price of this product in the market is difficult to determine. The change in its price depends on many reasons.
The first to bear the brunt is the cost of production. The price of raw materials is often variable. If the price of bromide, thiophene and other raw materials required for preparation rises, the cost of 4-bromo-2-thiophene formaldehyde will increase, and the price will rise. On the contrary, the price of raw materials decreases, and the price of products may be lowered.
Furthermore, the production process and technology also affect its price. The exquisite and advanced technology can increase the yield and reduce the loss, and the cost will be reduced accordingly, and the price may be close to the people. If the process is crude, the yield is low, the loss is numerous, and the cost is high, the price will be high.
The supply and demand situation of the market is also the key. If at some point, many industry players have a large increase in demand for 4-bromo-2-thiophene formaldehyde, but the supply is limited, the price will soar. If the supply exceeds the demand, the merchants will sell it for promotion, or reduce the price in order to get rid of it.
In addition, the state of market competition also affects the price. If there are many competitors in the same industry, the merchants will compete for market share, or make an article on the price to attract buyers at a low price. However, if there is no competition, exclusive operation or a few companies control, the price may be stable at a high level.
Looking at the changes in the market in the past, the price of 4-bromo-2-thiophene formaldehyde sometimes fluctuates violently, and sometimes it is relatively stable. To know the exact current price, you can get an accurate number by consulting the chemical product trading platform, the merchant specializing in chemical raw materials, or the information agency of the relevant industry.