4-BROMO-2-FORMYLTHIOPHENE

4-Bromo-2-formylthiophene, this is an organic compound with unique chemical properties.
In terms of its activity, both the aldehyde group and the bromine atom are active functional groups. The aldehyde group is active and can participate in many reactions. For example, in oxidation reactions, it is easily oxidized to carboxyl groups. Common oxidants such as potassium permanganate and Jones reagent can convert it into 4-bromo-2-thiophene formic acid. This reaction is often used in organic synthesis to construct carboxylic acids.
At the same time, aldehyde groups can undergo reduction reactions, such as sodium borohydride, lithium aluminum hydride and other reducing agents, which can be reduced to hydroxyl groups to generate 4-bromo-2- (hydroxymethyl) thiophene. This product has a wide range of uses in the preparation of hydroxythiophene derivatives.
The aldehyde group can also undergo classic nucleophilic addition reactions, such as acid catalysis with alcohols, which can form acetals. This reaction is often used to protect the aldehyde group from being affected in subsequent reactions, and then restore the aldehyde group by hydrolysis at an appropriate time.
And bromine atoms, which can undergo substitution reactions. In the nucleophilic substitution reaction, suitable nucleophiles such as sodium alcohol and amine can replace bromine atoms to form new organic compounds. Like reacting with sodium ethanol, 4-ethoxy-2-formylthiophene can be obtained, which is very important in the synthesis of ethoxylthiophene derivatives.
Moreover, bromine atoms can also participate in metal-catalyzed coupling reactions, such as Suzuki coupling reaction with aryl boric acid catalyzed by palladium, which can construct a biaryl structure and lay the foundation for the synthesis of organic materials with special structures and properties. 4-Bromo-2-formylthiophene is widely used in the field of organic synthesis due to its reactivity of aldehyde and bromine atoms. It can construct organic compounds with diverse structures through various reaction paths.

4-Bromo-2-formylthiophene is an important compound in the field of organic synthesis. Its main uses are extensive and are described as follows:
First, in the field of medicinal chemistry, it is a key intermediate. In the process of many drug development, 4-bromo-2-formylthiophene is often used to construct a specific chemical structure to achieve the desired pharmacological activity. Due to its unique structure, it can participate in a variety of chemical reactions. After ingenious modification and transformation, it can create drug molecules with specific therapeutic effects. For example, in some anti-tumor drug synthesis pathways, it can be used as a starting material to construct active ingredients that specifically bind to tumor cell targets through multi-step reactions.
Second, in the field of materials science, it also has important value. It can be used to prepare organic optoelectronic materials. Due to the good photoelectric properties of thiophene compounds, 4-bromo-2-formylthiophene, as a thiophene derivative, can be used to synthesize organic polymer materials with specific optical, electrical, and magnetic properties through rational design and polymerization. Such materials have potential applications in the fields of organic Light Emitting Diode (OLED) and organic solar cells, which can improve the performance and efficiency of devices.
Third, in organic synthetic chemistry, it is a commonly used synthetic building block. With its activity of bromine atom and formyl group, it can carry out many classical organic reactions, such as the coupling reaction of haloaromatic hydrocarbons, the condensation reaction of aldehyde groups, etc. With this, it can construct complex organic compounds, expand the structural diversity of organic molecules, and provide an effective tool for organic synthesis chemists to explore the relationship between structure and properties of novel compounds.
In conclusion, 4-bromo-2-formylthiophene, with its unique chemical structure, plays an indispensable role in many fields such as drugs, materials and organic synthesis, promoting the continuous development and progress of related fields.

To prepare 4-bromo-2-thiophene formaldehyde, the method of organic synthesis is often followed. Thiophene can be started from thiophene, and thiophene can be formylated first to obtain 2-thiophene formaldehyde. In this step, thiophene is mostly combined with N, N-dimethylformamide and phosphorus oxychloride to perform the Wilsmeer-Hack reaction. During the reaction, phosphorus oxychloride interacts with N, N-dimethylformamide to form an active intermediate, and the electron-rich thiophene ring is electrophilically substituted with it, and a formyl group is introduced to obtain 2-thiophene formaldehyde.
Then, 2-thiophene formaldehyde is brominated to obtain the target product. In this method of bromination, bromine or N-bromosuccinimide (NBS) is commonly used as the bromine source. Taking NBS as an example, in an appropriate solvent such as carbon tetrachloride, with benzoyl peroxide as the initiator, under light or heating conditions, NBS produces bromine free radicals, which attack the 4-position of 2-thiophenylformaldehyde. After the reaction, the product is purified by extraction, washing, drying, column chromatography or recrystallization to obtain pure 4-bromo-2-thiophenylformaldehyde. In this synthesis process, attention should be paid to the precise control of reaction conditions, and the yield and selectivity of each step of the reaction are related to the acquisition of the final product.

4-Bromo-2-formylthiophene is an organic compound. When storing and transporting, many key matters must be paid attention to.
Primary storage environment. It should be stored in a cool, dry and well-ventilated place. This compound is sensitive to heat, and high temperature can easily cause it to decompose or other chemical reactions, so it must be kept away from fire and heat sources. If the storage temperature is too high, or the molecular structure is changed, its chemical properties will change, which will affect subsequent use.
Secondary packaging material. It must be packaged with excellent sealing performance to prevent it from contacting with air and moisture. The aldehyde group in 4-bromo-2-formylthiophene is easily oxidized by oxygen in the air, and moisture may also promote reactions such as hydrolysis. Choosing appropriate packaging materials, such as glass bottles or specific plastic containers, can effectively avoid such situations.
When transporting, ensure its stability. Because the compound may be dangerous, severe vibration and collision must be prevented during transportation to avoid package damage and material leakage. At the same time, transportation vehicles need to be equipped with corresponding protective measures, such as heat insulation, fire protection and other equipment, to ensure transportation safety.
In addition, whether it is storage or transportation, relevant regulations and operating procedures should be strictly followed. Operators must receive professional training and be familiar with the characteristics of the compound and emergency treatment methods. In the event of an accident such as a leak, effective measures can be taken quickly to reduce the harm.
Storage and transportation of 4-bromo-2-formylthiophene must be treated with caution to ensure its quality and safety.

4-Bromo-2-formylthiophene, the price of this product in the market is difficult to determine. The price often varies due to many reasons, such as the quality of the product, the amount of purchase, the supply and demand of the market, and the difficulty of making it.
Looking at the past city, if the quality is good and the quantity is huge, the price may be slightly cheaper. However, if there are many people who want it, and the supply is thin, the price will rise. And if the preparation method is complicated and requires more materials and more work, the price will also be high.
According to the example of past transactions, the price may be between tens of yuan and hundreds of yuan per gram. However, this is only a rough figure, not an exact value. Today's market conditions are unpredictable, or due to the introduction of new methods, the production may increase, and the price may decrease; or due to the change in the price of raw materials, the cost may vary, and the price will also change. To know the exact price, you must consult the chemical material supplier in detail, or observe the detailed report of the recent market conditions, before you can get a near-real price.