3-thiophenepropanoic acid, beta-oxo-, ethyl ester

Beta-carbonyl-3-thiophenylpropionic acid ethyl ester, this is the name of a compound in organic chemistry. Looking at its name, its structural characteristics can be known. "3-thiophenylpropionic acid" indicates that this compound contains a thiophene ring, and the 3 position of the thiophene ring is connected to propionic acid. And "β-carbonyl" shows that there is a carbonyl group at the β position of propionic acid. "Ethyl ester" indicates that this compound is an ester of propionic acid and ethanol. This compound may have important uses in organic synthesis, medicinal chemistry and other fields. In organic synthesis, it may be used as a key intermediate for the construction of more complex organic molecules. In medicinal chemistry, or because of its unique structure, it exhibits specific biological activities, laying the foundation for the development of new drugs. The name of this compound accurately describes its structure and facilitates chemical research and production exchanges.

3-Thiophene propionic acid, β-oxo-, ethyl ester, this is an organic compound. It has a wide range of uses and is often used as an intermediate in drug synthesis in the field of medicine. Due to its specific chemical structure, it can participate in the construction of many drug molecules and help create drugs with specific physiological activities, such as antibacterial and anti-inflammatory drugs.
In the field of materials science, it also has important uses. Or it can be introduced into the structure of polymer materials through specific reactions to improve material properties, such as enhancing material stability, changing material optical properties, etc., and then applied to the development of new functional materials.
In the field of organic synthesis, it is a key intermediate. With its active groups, it can combine with other organic compounds through esterification, condensation and other reactions to form complex organic molecular structures, providing a basis for the synthesis of novel organic compounds and promoting the development of organic synthetic chemistry.
The versatile uses of this compound depend on its unique chemical structure and reactivity, and it is an important substance for research and application in organic chemistry and related fields.

3-Thiophene propionic acid, β-oxo-, ethyl ester, this is one of the organic compounds. Its physical properties are quite worthy of detailed observation.
Looking at its appearance, under normal temperature and pressure, it is mostly colorless to light yellow liquid. This color state is clear and easy to recognize.
As for its smell, it often has a specific fragrance, but this fragrance is not a fresh fragrance that everyone likes, but has a unique smell, which can be used as one of the characteristics to identify this compound.
When it comes to boiling point, it is usually in a specific temperature range, about [X] ° C. This boiling point value is closely related to its molecular structure and intermolecular forces. Due to the interaction of atoms in the molecule, under the action of specific thermal energy, a substance can change from a liquid state to a gaseous state.
Melting point is also one of the important physical properties. Its melting point is about [X] ° C. When the temperature drops to this point, the substance will solidify from a liquid state to a solid state. This transition is of great significance in the field of chemical industry and materials science, which is related to its storage and application conditions.
In terms of solubility, it exhibits good solubility in organic solvents, such as ethanol, ether, etc. This is because the molecules of the compound can form specific interactions with organic solvent molecules, such as hydrogen bonds, van der Waals forces, etc., so they are mutually soluble. However, in water, its solubility is relatively limited, due to the difference between the polarity of water and the polarity of the compound.
The density is also a key consideration. Its density is about [X] g/cm ³, which is in a specific range compared with common organic liquids. This density characteristic affects its distribution and behavior in the mixed system.
In summary, the physical properties of 3-thiophenylpropionic acid, β-oxo-, and ethyl ester have their own characteristics from appearance, odor, melting and boiling point, solubility to density. These characteristics together describe the physical appearance of the compound and lay the foundation for its application in many fields such as chemical industry and medicine.

3-Thiophene propionic acid, β-carbonyl-, ethyl ester, the chemical properties of this substance are of great value for investigation. Its appearance is often colorless to pale yellow liquid, or crystalline solid, depending on the environmental conditions.
On solubility, this substance exhibits good solubility in common organic solvents such as ethanol, ether, chloroform, etc. This property is due to the interaction between its molecular structure and organic solvent molecules, making it easier to disperse in organic solvent systems.
In terms of chemical reactivity, the β-carbonyl structure gives it unique chemical activity. The carbonyl group in this structure has strong electrophilicity and is easy to react with nucleophiles. For example, it can condensate with alcohols under the catalytic conditions of acids or bases to generate corresponding ketals or acetals. At the same time, the existence of β-carbonyl also makes the substance prone to enolization tautomerism, which is of great significance in organic synthesis and can be used as a reaction intermediate to participate in the synthesis of many complex organic compounds. The existence of
thiophene ring also adds different chemical properties to the substance. The thiophene ring has a certain aromaticity, although slightly weaker than the benzene ring, but its electron cloud distribution characteristics enable electrophilic substitution reactions to occur on the thiophene ring. If under appropriate reaction conditions, halogenation can occur with halogenated reagents, and halogen atoms are introduced into the thiophene ring, which provides the possibility for subsequent functional group transformation and modification.
Furthermore, its ester structure also has typical chemical properties. Under the catalytic action of acid or base, hydrolysis can occur. Hydrolysis under acidic conditions produces 3-thiophene propionic acid and ethanol, and hydrolysis under basic conditions produces corresponding carboxylate and ethanol. This hydrolysis reaction is often used in the field of organic synthesis and medicinal chemistry, and is often used for the preparation and structural modification of target products.

To prepare 3-thiophene propionic acid, β-carbonyl-, ethyl ester, the method is as follows:
First, thiophene is taken as the starting material, and the thiophene and oxaloyl chloride monoethyl ester are acylated. In this reaction, the catalyst is often selected as Lewis acid such as anhydrous aluminum trichloride, and in a low temperature and anhydrous environment, the oxaloyl chloride monoethyl ester is slowly dropped into the reaction system containing thiophene and catalyst. This acylation step can obtain the key intermediate, namely 3- (2-ethoxy-2-oxoacetyl) thiophene.
Then, the intermediate is reduced. A mild reducing agent, such as sodium borohydride, is often used to reduce in alcoholic solvents. Sodium borohydride can selectively reduce the carbonyl group in the intermediate to the hydroxyl group to obtain 3- (2-ethoxy-2-hydroxyacetyl) thiophene.
Then the resulting product undergoes a dehydration reaction. Appropriate dehydrating agents, such as concentrated sulfuric acid or p-toluenesulfonic acid, are selected under heating conditions to promote the dehydration of water from the hydroxyl group and the ortho-hydrogen to form a double bond to obtain 3- (2-ethoxy vinyl) thiophene.
Finally, by reacting with diethyl malonate under basic conditions, basic reagents such as sodium ethyl alcohol, etc., make the two condensate. After hydrolysis and decarboxylation, the target products 3-thiophenylpropionic acid, β-carbony- and ethyl ester can be obtained. The whole process needs to pay attention to the precise control of the reaction conditions and the purification of the reaction products in each step to improve the yield and purity of the final product.