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3-thiophenemethanamine, what is the chemical structure of N-methyl-
3 - thiophenemethanamine, N - methyl -, the analysis of its chemical structure is a matter of great importance in the field of chemistry. According to its naming rules, the core structure of this compound can be known as a thiophene ring. The thiophene ring is a sulfur-containing five-membered heterocyclic ring with unique electron cloud distribution and chemical properties.
At the 3rd position of the thiophene ring, there is a -CH -2 NH - structure connected, which is methylamino methyl. In methylamino methyl, there is a methyl (N - methyl) attached to the nitrogen atom. From this point of view, the chemical structure of the compound is composed of a thiophene ring as the main body, which is connected to N-methylmethylamine group through methylene (-CH -2 -). The electron cloud distribution of the
thiophene ring is different from that of the benzene ring due to the existence of sulfur atoms, which makes its chemical activity and reaction check point unique. The nitrogen atom in the -CH -2 NH - structure has lone pair electrons and can participate in many chemical reactions, such as nucleophilic reactions. The introduction of N-methyl also affects the physical and chemical properties of the compound, such as changing its steric resistance and electronic effects.
The chemical structure of this compound lays the foundation for further investigation of its chemical properties, synthesis methods and potential applications. Its unique structure may make it show unique value and application prospects in organic synthesis, drug development and other fields.
3-thiophenemethanamine, what are the physical properties of N-methyl-
3-Thiophenomethylamine, N-methyl-The physical properties of this substance are really related to the important aspects of its material characteristics. Under normal temperature, it may be in a liquid state, and the color state is pure when viewed, or it is colorless and transparent, like a clear spring, without the disturbance of variegated colors, and the texture is uniform and stable.
Smell it, its smell may have a unique fragrance, but it is not pungent and intolerable. On the contrary, it has a subtle fragrance. Although it is not rich, it lingers in the air, and if it is absent, it will attract people to explore.
As for its density, it may be different from common water. The density of water is one gram per cubic centimeter, and the density of this substance is finely calculated, or slightly higher than that of water. When weighed in the hand, if it is contained in a container of the same volume, it will feel more heavy, as if it carries many unknown mysteries.
Its solubility is also a key characteristic. In organic solvents, such as ethanol, ether, etc., this substance may exhibit good solubility and can quickly blend with the solvent, just like water emulsion, without distinction, forming a uniform and stable solution. However, in water, its solubility may not be good, just like the barrier between oil and water, it is difficult to be intimate, and it will show a layered state, with the supernatant and the lower layer being this substance.
Furthermore, its melting point and boiling point cannot be ignored. At the melting point, this object may quietly transform from a solid state to a liquid state, just like the first melting of ice and snow, gentle and delicate. At the boiling point, it turns from a liquid state to a gaseous state, curling and rising, as if telling its own wonderful changes in the air. The exploration of these physical properties is the key to understanding this object in depth.
3-thiophenemethanamine, what are the common uses of N-methyl-
3-thiophenemethanamine, N-methyl- (N-methyl-3-thiophenomethylamine) is often prepared by organic synthesis. The preparation of this compound often requires chemical synthesis, according to various organic reaction mechanisms.
In the past, organic synthesis mostly used compounds containing thiophene structures as starting materials. Common ones, such as thiophene-based, first introduce halomethyl, which can be obtained by halogenating reagents, such as a mixture of hydrogen halide and formaldehyde. Under suitable reaction conditions, thiophene is chloromethylated or bromomethylated to obtain thiophene halomethyl derivatives.
Then, attack the halogenated methyl group with a nitrogen-containing nucleophilic reagent. This nucleophilic reagent is often selected from methylamine and the like. The nitrogen atom of methylamine has a lone pair electron, which is quite nucleophilic and can undergo a nucleophilic substitution reaction with the halogenated methyl group. In a suitable solvent, such as a polar aprotic solvent, the reaction can proceed smoothly. During the nucleophilic substitution reaction, the halogen atom leaves, and the nitrogen atom of the methylamine bonds with the carbon atom of the thiophene halogenated methyl derivative, and then N-methyl-3-thiophene methylamine is obtained.
There are other methods, or the thiophene-containing amine structure is constructed first, The methylation method can use methylation reagents such as iodomethane. Under the catalysis of alkali, the amine group is methylated to obtain the final product.
During the preparation process, all reaction conditions need to be carefully controlled. The temperature has a great impact on the reaction rate and selectivity. The choice of solvent is related to the solubility of the reactants and the direction of the reaction mechanism. The ratio of reactants also affects the yield and purity of the reaction. All these need to be carefully studied by organic synthesizers to obtain 3-thiophenemethanamine, N-methyl - efficiently and purely.
3-thiophenemethanamine, what are the synthesis methods of N-methyl-
To prepare 3-thiophenylmethylamine, N-methyl-, there are various methods. This is described in detail by Jun.
First, 3-thiophenylformaldehyde can be started. First, 3-thiophenylformaldehyde is reacted with methylamine by reducing amination. This process requires the power of a reducing agent, such as sodium cyanoborohydride. This reducing agent can effectively reduce the generated imine intermediate in the reaction system, and finally obtain the target product 3-thiophenylmethylamine, N-methyl-. The reaction is often carried out in a suitable organic solvent, such as methanol or ethanol, which can provide a suitable environment for the reactants and promote the smooth reaction. And the reaction temperature and time also need to be fine-tuned, the general temperature is controlled between room temperature and 50 degrees Celsius, the reaction after several hours, depending on the monitoring of the reaction process, commonly used thin-layer chromatography to observe.
Second, 3-bromothiophene is used as raw material. Shilling it and magnesium chips to prepare Grignard reagent. This Grignard reagent is quite active, and then reacts with N-methylformamide to introduce methylamino. Then through hydrolysis steps, 3-thiophene methylamine, N-methyl- can be obtained. When preparing Grignard reagent, it needs to be under severe conditions of anhydrous and anaerobic to ensure the activity and stability of Grignard reagent. The solvent used in the reaction is mostly anhydrous ethyl ether or tetrahydrofuran. The subsequent hydrolysis step is usually a dilute acid, such as dilute hydrochloric acid, which can control the appropriate reaction conditions and make the product yield better.
Third, start from 3-thiophene acetic acid. First, 3-thiophene acetic acid is converted into the corresponding acid chloride, and thiophene chloride is often used to achieve this step. The acid chloride has higher activity, and then reacts with methylamine to form an amide. Finally, the amide is reduced by a strong reducing agent such as lithium aluminum hydride to obtain 3-thiophene methylamine, N-methyl-. When preparing the acid chloride, an appropriate amount of thionyl chloride is required, and the reaction should be initiated at low temperature and gradually raised to room temperature. When reducing amide with lithium aluminum hydride, it is also necessary to control the dosage and reaction temperature under anhydrous conditions to prevent overreaction.
All these methods have their own advantages and disadvantages. In actual preparation, when considering the availability of raw materials, cost, difficulty of reaction conditions and many other factors, the purpose of efficient preparation of 3-thiophenomethylamine and N-methyl can be achieved.
3-thiophenemethanamine, N-methyl- What are the safety precautions?
3-Thiophenomethylamine, N-methyl - This substance involves many safety precautions and needs to be treated with caution. In chemical experiments or industrial applications, the first thing to pay attention to is toxicity. The cover is potentially toxic, or can invade the human body through respiratory tract, skin contact or accidental ingestion, causing damage to health. In light cases, dizziness, nausea, severe cases or organ damage. Therefore, when operating, be sure to wear complete protective equipment, such as gas masks, gloves, protective clothing, etc., to prevent its damage.
Second, the substance is flammable. In case of open flames, hot topics or strong oxidants, it is easy to cause the danger of combustion or even explosion. When storing, it must be kept away from fire and heat sources, placed in a cool and ventilated warehouse, and stored separately from oxidants, acids, etc., and should not be mixed. At the operation site, fireworks are strictly prohibited, and electrical equipment must also meet explosion-proof standards to prevent sparks from causing accidents.
Furthermore, its stability also needs attention. Under specific conditions, decomposition reactions may occur to generate harmful gases. During use, factors such as high temperature, high pressure and strong light exposure that may affect its stability should be avoided. At the same time, it is necessary to be familiar with its chemical properties and avoid contact with incompatible substances to prevent dangerous chemical reactions.
The handling process should not be ignored, and care should be taken to prevent damage to the packaging container. In case of accidental leakage, an emergency plan should be activated immediately, evacuate personnel to a safe area, and cut off the fire source. Small leaks can be absorbed by inert materials such as sand and vermiculite; large leaks need to be built embankment or dug for containment, and transferred to a special container with an explosion-proof pump for proper disposal. In this way, the safety of the process of using 3-thiophenylmethylamine and N-methyl can be ensured.
