3-THIOPHENEETHANOL

3-pentanone isonitrile, also known as 3-cyanopentane, has the following main uses:
3-pentanone isonitrile has a wide range of uses in the field of organic synthesis. In the process of building complex organic molecular structures, its isonitrile groups have unique properties and can participate in a variety of chemical reactions. For example, in the classic Ugi reaction, 3-pentanone isonitrile can undergo multi-component condensation reactions with alaldehyde, amine and carboxylic acid to generate products with multiple functional groups in one step. Such polyfunctional compounds are of great significance in pharmaceutical chemistry and are often used as key intermediates to develop new drug molecules. Taking the research and development of a new type of anti-tumor drug as an example, the intermediate synthesized by using 3-pentanone isonitrile participating in the Ugi reaction was successfully modified to obtain a lead compound with significant inhibitory activity on tumor cells.
In terms of materials science, 3-pentanone isonitrile also shows certain value. Because its molecular structure has a special activity check point, it can be connected to the main chain or side chain of the polymer through a specific chemical reaction. In this way, the polymer material can be given new properties, such as changing the hydrophilicity of the material surface and improving the compatibility of the material with other substances. For example, in the preparation of high-performance coatings, 3-pentanone isonitrile-derived functional groups are introduced into the polymer system, resulting in enhanced adhesion to the substrate and improved weather resistance.
In addition, in the preparation of some fine chemicals, 3-pentanone isonitrile can be used as a unique structural unit. Due to the special electronic and spatial effects of isonitrile groups, it can bring unique physicochemical properties to fine chemicals. For example, when preparing some fine chemicals with special optical or electrical properties, 3-pentanone isonitrile participates in the reaction to form structural fragments, which helps to achieve the required special properties of the product.

First, glutinous rice, which is sticky to the ground. Its properties are rich in flour, boiled in water, and gelatinized. It can make the porridge thick and thick, giving the porridge a dense taste, and has the effect of strengthening the spleen.
Second barley, the grains are thick, and the color is white. The barley is hard on the ground and needs to be soaked. Its taste is sweet, light, and slightly cold, rich in protein, fat, carbohydrates, etc. The cooking is slightly good, which can benefit the water, strengthen the spleen and remove paralysis.
In addition, it is hard on the outside, and the nuts are white. The ground is thick, and it needs to be treated first. Its taste is sweet, sweet, flat in nature, rich in gluten and protein. Boiled, the taste is pink and waxy, which can strengthen the spleen and stop the spleen, and solidify the essence.
These three are combined to form three porridge, and the stickiness of glutinous rice, the stickiness of barley kernels, and the waxy of thickening are blended with each other. When boiled, the glutinous rice is gelatinized to make the porridge thick; the barley kernels are thick in it, and the taste is rich for many times. And in terms of physics, the three are the best of water and fire, and they are integrated into one, which is not delicious, but also has a good effect. Eating it can make the spleen and stomach healthy, and you can get good food.

Ethyl 3-pentanoate, also known as ethyl β-pentanoate, is an organic compound with unique physical and chemical properties and a wide range of uses in the field of organic synthesis. The following are its main chemical properties:
1. ** Ketone reaction **: Ethyl 3-pentanoate molecules contain ketone groups (C = O), which are active functional groups and can undergo many reactions. For example, it can carry out nucleophilic addition reactions with nucleophiles. Take the reaction with Grignard reagents as an example. The negatively charged hydrocarbon group (R-) in Grignard reagent (RMgX) acts as a nucleophilic reagent to attack the positively charged carbonyl carbon atoms in the ketone group to generate alcohols. The reaction process is as follows: The hydrocarbon group of Grignard's reagent is first added to the carbonyl carbon of the ketone group to form a magnesium oxide halide intermediate. After hydrolysis, the magnesium oxide halide is converted into a hydroxyl group to obtain an alcohol product. In addition, the ketone group can be reduced under the action of a reducing agent. For example, the use of reducing agents such as lithium aluminum hydride (LiAlH) or sodium borohydride (NaBH) can reduce the ketone group to an alcohol hydroxyl group. Among them, the reduction selectivity of sodium borohydride is high, usually only the ketone group is reduced, and the effect on other functional groups in the molecule is small.
2. ** Reaction of ester groups **: This compound also contains an ester group (-COOEt), and the ester group can undergo hydrolysis reaction. Under acidic conditions, ethyl 3-pentanoate is hydrolyzed to produce 3-pentanoic acid and ethanol. This reaction is reversible and generally requires heating and excess acid catalysis to prompt the reaction to proceed to the right. Under basic conditions, such as reacting with sodium hydroxide solution, the hydrolysis is more complete, resulting in sodium 3-pentanoate and ethanol. After acidification treatment, 3-pentanoic acid can be obtained. The ester group can also participate in the alcoholysis reaction. Under acid or base catalysis, the ethoxy group of ethyl 3-pentanoate can be replaced by the alkoxy groups of other alcohols to form new ester compounds.
3. ** Reaction of α-hydrogen **: The hydrogen (α-hydrogen) on the α-carbon atom connected to the ketone group or ester group has a certain acidity, and it is easy to leave under the action of a strong base to form a carbon negative ion. This carbon negative ion can participate in a variety of reactions as a nucleophilic reagent. For example, under the action of a strong base such as sodium ethyl alcohol, the α-hydrogen of ethyl 3-pentanoate leaves, and the generated carbon negative ions can attack halogenated hydrocarbons. A nucleophilic substitution reaction occurs, and an alkyl group is introduced into the α-carbon atom. This is an important method for constructing carbon-carbon bonds. At the same time, α-hydrogen can also participate in condensation reactions, such as hydroxyaldehyde condensation with another molecule of carbonyl-containing compounds under basic conditions to generate β-hydroxycarbonyl compounds, which can then be dehydrated to form α, β-unsaturated carbonyl compounds.

There are various ways to synthesize 3-bromopyruvate, which are described as follows:
First, pyruvate is used as the starting material and bromination is carried out with brominating reagents. The commonly used brominating reagents include bromine, phosphorus tribromide, etc. Taking bromine as an example, in appropriate reaction solvents, such as dichloromethane and chloroform, under the action of catalysts such as benzoyl peroxide, pyruvate and bromine can be substituted to produce 3-bromopyruvate. The reaction mechanism is roughly as follows. The catalyst leads to the release of free radicals, which promotes the generation of bromine free radicals. Bromine free radicals attack the α-carbon atom of pyruvate, and through a series of complex processes, α-hydrogen is replaced by bromine atoms to obtain the target product. This method is relatively simple to operate, and the raw materials are easy to obtain. However, the reaction conditions need to be carefully controlled, otherwise it is easy to cause side reactions to occur, and impurities such as polybrominated products are formed, which affects the purity and yield of the product.
Second, starting from lactic acid, the lactic acid is oxidized to pyruvate acid first, and then brominated. The commonly used oxidizing agents for lactic acid oxidation are potassium permanganate, potassium dichromate, etc. Take potassium dichromate as an example. Under acidic conditions, potassium dichromate can oxidize lactic Subsequently, according to the above bromination method using pyruvate as raw material, 3-bromopyruvate acid can be obtained. This route has more oxidation steps. Although the process is slightly complicated, it can take advantage of the wide source of lactic acid and low price. If the oxidation reaction conditions are properly controlled, higher purity pyruvate can be obtained, which lays a good foundation for subsequent bromination. Finally, the ideal yield and purity of 3-bromopyruvate can be obtained.
Third, using ethyl acetoacetate as raw material, acetone is first decarboxylated by water to obtain acetone, and then 3-bromopyruvate is synthesized by α-bromination and oxidation. Ethyl acetoacetate is hydrolyzed under alkaline conditions, and then acidified and heated to decarboxylate to produce acetone. Under appropriate conditions, acetone is brominated with a brominating agent to obtain α-bromoacetone, and then oxidized. For example, using Jones reagent, α-bromoacetone can be oxidized to 3-bromopyruvate. This method has many steps, but the reaction selectivity of each step is relatively good. By optimizing the reaction conditions of each step, the overall reaction efficiency and product quality can be effectively improved.

In today's world, the price of 3-bromopyruvate varies from market to market due to supply and demand, craftsmanship, and quality.
This product is very useful in the research of medical science and the production of medicinal stones, so there are many people who seek it, and its price is not constant. Looking at the market conditions, if the product is of high quality and well prepared, the price per gram is often hundreds of dollars. However, there are also those whose price is slightly inferior due to mass production, or between a hundred and ten dollars.
As for the price range, roughly speaking, ordinary products, starting from eighty dollars per gram, can reach five or six hundred dollars. If there is an imbalance in supply and demand, or there is a new change in the system, the price will also fluctuate. The market is unpredictable, and the price is difficult to determine. It can only be judged according to the situation of the time and the quality of the goods.
If you want to know the exact price, you must consult the people of Jia, visit the market, or observe the list prices of merchants to get the details.