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What is the main use of 3-THIOPHENEETHANOL 98 +%?
3-Thiophene ethanol, with a content of more than 98%, has a wide range of uses. In the field of medicine, it is often a key raw material and can participate in the synthesis of a variety of drugs. For example, some anti-infective drugs with specific curative effects, 3-thiophene ethanol plays an indispensable role in its synthesis pathway. With its unique chemical structure, it imparts specific activities and functions to drug molecules.
In the field of materials science, it also has important uses. It can be used as a starting material for the synthesis of functional materials. After specific chemical reactions, it can be converted into materials with special properties, such as some adsorption materials with high selective adsorption capacity for specific substances, or new materials that exhibit unique physical properties under specific light and electrical conditions.
In the field of organic synthetic chemistry, 3-thiophene ethanol, as an important organic intermediate, can construct more complex organic compound structures through various chemical reactions, such as esterification, substitution, addition, etc., providing a rich building block for organic synthetic chemists, assisting in the creation and development of new organic compounds, thus promoting the continuous development and innovation of the field of organic chemistry.
What is the storage condition of 3-THIOPHENEETHANOL 98 +%?
3-Thiophene ethanol, its content is as high as 98% or more. When storing, it is necessary to strictly abide by specific regulations according to its physical and chemical properties to keep it safe.
This substance is volatile to a certain extent and is quite sensitive to air and humidity. Therefore, it should be stored in a cool, dry and well-ventilated place. It must not be placed in a high temperature place, because high temperature can easily cause its volatilization to intensify, or even cause chemical reactions, resulting in quality damage. The temperature should not exceed 25 ° C.
Humidity must also be strictly controlled. If the ambient humidity is too high, it may cause 3-thiophene ethanol to absorb moisture, which will affect its purity. The humidity in the storage place should be maintained at 40% - 60%.
Furthermore, 3-thiophene ethanol should be kept away from fire sources, heat sources and oxidants. Because of its flammability, in case of open flames, hot topics or contact with oxidants, there is a risk of combustion and explosion. And it needs to be stored separately from oxidants, acids, bases, etc., and must not be mixed to prevent dangerous chemical reactions.
Packaging should also not be ignored. Sealed packaging should be used to ensure that it is isolated from outside air, moisture, etc. Commonly used packaging materials include glass bottles, plastic bottles, etc. However, it is necessary to ensure that the packaging material does not react with 3-thiophene ethanol. During storage, the integrity of the packaging should also be checked regularly. If there is any damage, it needs to be dealt with in time to prevent leakage.
What are the preparation methods of 3-THIOPHENEETHANOL 98 +%?
There are several methods for preparing 3-thiophene ethanol (3-THIOPHENEETHANOL) with a purity of more than 98%.
First, thiophene is used as the starting material. First, thiophene is reacted with ethylene oxide under the action of a specific catalyst. This reaction needs to be carried out in a suitable temperature and pressure environment, the temperature is usually controlled between tens of degrees Celsius and 100 degrees Celsius, and the pressure is also adjusted as needed. The catalyst can be a specific metal salt or an organometallic compound. The activity check point of thiophene undergoes a nucleophilic substitution reaction with ethylene oxide to generate the corresponding intermediate. Then the intermediate is hydrolyzed, and under acidic or basic conditions, the intermediate is converted into 3-thiophene ethanol. After this process, the product with high purity can be obtained through distillation, extraction, recrystallization and other purification steps.
Second, thiophene acetic acid is prepared as a raw material. First, thiophene acetic acid is reduced, and suitable reducing agents such as sodium borohydride and lithium aluminum hydride can be selected. In a suitable solvent, under low temperature or room temperature conditions, the reducing agent reduces the carboxyl group of thiophene acetic acid to hydroxyl groups to generate 3-thiophene ethanol. This process requires attention to the precise control of the amount of reducing agent and reaction conditions to ensure the selectivity and yield of the reaction. After the reaction, the product is purified by distillation, column chromatography and other separation methods to improve its purity to more than 98%.
Third, halogenated thiophene and ethanol-related derivatives are used as raw materials. Halogenated thiophene and metal-organic reagents containing ethanol structure, such as ethanol magnesium halide, etc., undergo Grignard reaction under the condition of anhydrous and oxygen-free and the presence of suitable catalysts. The halogen atom of halogenated thiophene is replaced by ethanol group to generate 3-thiophene ethanol. After the reaction is completed, the impurities are removed through hydrolysis, separation and purification to obtain high-purity 3-thiophene ethanol. All steps need to be carefully operated, and attention should be paid to the regulation of reaction conditions and the separation and purification of products, in order to achieve the purity requirement of more than 98%.
What is the market price range of 3-THIOPHENEETHANOL 98 +%?
3-Thiophene ethanol, with a content of more than 98%, the market price range is difficult to determine due to many factors. The price of Guanfu's materials in the past often depended on the state of supply and demand, the source of origin, and the difference in quality, and sometimes fluctuated due to changes in the current situation and process.
In the past, if the supply of such chemical materials was abundant and the demand was normal, the price might be relatively average; however, if the demand surged and the supply was limited, if the demand for it in a certain industry suddenly increased, and the output did not keep up, the price would rise. And the distance of the origin is related to the cost of transportation, which can also affect the price. If the origin is remote and the transportation is difficult, the cost will increase, and the price will follow.
Furthermore, whether the quality is excellent or not has a great impact on the price. The higher the purity, the less impurities, suitable for high-end craftsmanship, and the price will be higher; if it contains more impurities, it is only suitable for ordinary manufacturing processes, and the price will be slightly lower. However, due to the lack of exact data at the time, it is difficult to determine the current market price range for those with a purity of more than 98%. It is generally necessary to check the recent transaction price in the place of chemical materials trading, and consult industry experts and experts to obtain a more accurate number.
What is the quality inspection standard of 3-THIOPHENEETHANOL 98 +%?
3-Thiophene ethanol, its purity of more than 98% quality testing standards, related to the characteristics of this material, components, impurities and many other aspects.
The first to bear the brunt is the appearance testing. 3-Thiophene ethanol should appear as a colorless to light yellow liquid. If the color is different or cloudy, it will not meet the standard. This is a visual method to visually distinguish its phase.
For the second time, the purity determination is crucial. With precision instruments such as gas chromatography (GC) or high-performance liquid chromatography (HPLC), the proportion of 3-thiophene ethanol in the sample can be accurately determined. The established standard needs to reach more than 98%. If it is lower than this value, it will be considered unqualified regardless of the amount of impurities.
Furthermore, the moisture content must also be strictly controlled. Because it may affect the chemical properties and stability of 3-thiophene ethanol, it is often determined by Karl Fischer method. Usually, the moisture content should be maintained at a very low level to prevent adverse effects on subsequent use.
In addition, the detection of impurities cannot be ignored. In addition to the main components, the sample may contain other organic impurities, metal impurities, etc. Organic impurities can be detected by chromatography, while metal impurities are often determined by atomic absorption spectroscopy (AAS) or inductively coupled plasma mass spectrometry (ICP-MS). All kinds of impurities have corresponding limits, and if they exceed the quality requirements, they will not meet the quality requirements.
Physical properties such as melting point and boiling point are also key indicators for quality testing. 3-thiophene ethanol has its specific melting boiling point range, deviating from this range may suggest that the sample is impure or has other abnormalities. By accurately measuring the melting boiling point, it can be further confirmed whether its quality is up to standard.