3-Thiophenecarboxylic acid, 5-bromo-, methyl ester

Methyl 5-bromo-3-thiophenecarboxylate is an important raw material for organic synthesis. It has a wide range of uses and can be used as a key intermediate in the field of medicinal chemistry to prepare drug molecules with specific biological activities. In the process of drug development, with its unique structure, complex compounds with therapeutic effects can be constructed through a series of chemical reactions.
In the field of materials science, it also plays a key role. It can be used to synthesize materials with special photoelectric properties, such as organic Light Emitting Diode (OLED) materials. Due to the existence of thiophene structure, the material is endowed with unique electron transport and optical properties, which contribute significantly to improving the luminous efficiency and stability of OLED devices.
In the field of pesticide chemistry, it is also an important synthetic building block. By reacting with other compounds, pesticide products with high-efficiency insecticidal, bactericidal or herbicidal activities can be generated, which can help agricultural production pest control.
In short, methyl 5-bromo-3-thiophenecarboxylate plays an indispensable role in many fields due to its unique chemical structure, making great contributions to the development of various fields.

The method of preparing methyl 5-bromo-3-thiophenecarboxylate has been explored by many scholars in the past, and now the common ones are described.
First, 3-thiophenecarboxylic acid is used as the starting material. First, 3-thiophenecarboxylic acid and appropriate brominating reagents, such as liquid bromine or N-bromosuccinimide (NBS), in a suitable reaction medium, often in an inert organic solvent such as dichloromethane, etc., under the action of catalysts such as benzoyl peroxide, heating or light initiates the reaction, and 5-bromo-3-thiophenecarboxylic acid can be obtained. In this process, bromine atoms selectively replace hydrogen atoms at the 3-position of the thiophene ring, which is due to the electron cloud distribution characteristics of the thiophene ring. Subsequently, the obtained 5-bromo-3-thiophenecarboxylic acid is mixed with methanol, an appropriate amount of concentrated sulfuric acid or p-toluenesulfonic acid is added as a catalyst, and the esterification reaction is carried out by heating to obtain methyl 5-bromo-3-thiophenecarboxylate. This reaction uses the principle of dehydration of acids and alcohols under the action of catalysts to form esters, which is relatively simple to operate. However, attention should be paid to the control of reaction conditions to improve the yield and purity.
Second, thiophene is used as the starting material. 5-Bromothiophene was prepared by electrophilic substitution reaction of thiophene with brominating reagent. After that, 5-bromothiophene was reacted with magnesium chips in anhydrous ether and other solvents by Grignard reagent method to generate corresponding Grignard reagent. Then the Grignard reagent was reacted with carbon dioxide to introduce carboxyl groups, and then acidified to obtain 5-bromo-3-thiophenecarboxylic acid. Finally, 5-bromo-3-thiophenecarboxylic acid was obtained by esterification with methanol in the previous method. Although this path is slightly complicated, the raw materials are easy to obtain, and the reaction process and product selectivity can be adjusted according to different reaction conditions. It is also used in industrial preparation.

The physical and chemical properties of methyl 5-bromo-3-thiophenecarboxylate are as follows:
Looking at its morphology, at room temperature, methyl 5-bromo-3-thiophenecarboxylate is often white to light yellow crystalline powder. This state is conducive to storage and use, and the texture of the powder is delicate, reflecting the characteristics of its microstructure.
The melting point is between 62 and 66 ° C. The melting point is an inherent characteristic of the substance. In this temperature range, the solid state of methyl 5-bromo-3-thiophenecarboxylate will absorb heat, disintegrate the lattice structure, and transform into a liquid state. The stability of this temperature range has a great impact on its existence and application under different conditions.
As for solubility, it is soluble in common organic solvents such as dichloromethane, chloroform, ethyl acetate, etc. The polarity and molecular structure of the organic solvent interact with methyl 5-bromo-3-thiophenecarboxylate to make it uniformly dispersed in molecular or ionic states. However, the solubility in water is not good, because the polarity of water and the molecular structure of methyl 5-bromo-3-thiophenecarboxylate are quite different, the interaction force between the two is difficult to overcome its own intermolecular force, so it is difficult to dissolve.
The chemical properties of methyl 5-bromo-3-thiophenecarboxylate are also worthy of attention. In its molecular structure, thiophene ring endows it with certain aromaticity and stability; the existence of bromine atoms makes it have some properties of halogenated hydrocarbons, which can occur nucleophilic substitution reaction, providing activity check point for organic synthesis; and methyl ester groups can participate in various chemical reactions such as hydrolysis and alcoholysis, which are widely used in the field of organic synthesis. In the preparation process of fine chemical products, they often participate in the reaction as key intermediates to realize the construction and transformation of molecular structures.

3-Thiophenecarboxylic acid, 5-bromo-, methyl ester, this product is in the market price range, due to the complex and changeable market conditions, it is difficult to determine the number. In the past, in the world of "Tiangong Kaiwu", although there was no such fine chemical product, it made sense. In today's chemical market, the price of this compound is affected by many factors. The abundance of its raw materials, if the raw materials are easily available, the price may be slightly flat; if the raw materials are scarce, the price will rise. Furthermore, the preparation process is difficult, if the preparation process is complicated, many exquisite skills and precious reagents are required, the cost will be high, and the price will also rise. And the amount of market demand, if there are many people, the supply is in short supply, and the price must be high; if there is little demand, the supply exceeds the demand, and the price will decline. According to my multi-party investigation, the price of this product in the market may fluctuate between tens of yuan and hundreds of yuan per gram. However, this is only a rough number. The actual price should be subject to the real-time market conditions. When purchasing, you should inquire in detail and compare with many parties to get a suitable price.

3-Thiophenecarboxylic acid, 5-bromo-, methyl ester This is a matter of safety and should be paid careful attention. This is a chemical substance, sexual or lively, and the first protection when handling. It is necessary to fit protective equipment, such as gloves and goggles, to prevent it from touching the skin and eyes and causing injuries. Because it may be irritating and corrosive, if it is accidentally contaminated, rinse it with plenty of water as soon as possible and seek medical attention.
Furthermore, it is necessary to operate in a well-ventilated place. Because of its volatile gas, or harmful to the body, causing respiratory discomfort and other diseases. If working in a confined space, a ventilation device must be installed to disperse harmful gases. < Br >
When storing, also be cautious. It should be placed in a cool, dry and ventilated place, away from fire and heat sources to prevent the risk of fire and explosion. And should be stored separately with oxidants, acids, alkalis, etc., to avoid their mutual reaction and cause danger.
When taking it, weigh it accurately, and operate according to the standard process. Do not use it in excess, and do not mix other substances at will to avoid unpredictable reactions.
In addition, dispose of the waste of this material in accordance with environmental regulations. Do not discard it at will to avoid polluting the environment. It needs to be collected and treated in the specified way to ensure the safety of the environment.
In short, the handling of 3-thiophenecarboxylic acid, 5-bromo-, methyl ester, must strictly abide by safety procedures, prevent micro-gradually, in order to ensure the integrity of people, things and environments.