3-Thiophenecarbonitrile,2-amino-5-methyl-

In order to clarify its chemical structure, it is necessary to analyze it according to the principles of organic chemistry.
thiophene is a five-membered heterocyclic compound containing sulfur, and its ring has a conjugated system, which is quite stable. "3 - -thiophenoformonitrile" is connected to a formonitrile group (-CN) at the 3rd position of the thiophene ring. This formonitrile group is a strong electron-absorbing group, which can affect the electron cloud distribution of the thiophene ring.
Furthermore, "2-amino-5-methyl-" indicates that there is an amino group (-NH _ 2) at the 2nd position of the thiophene ring, and a methyl group (-CH _ 3) at the 5th position. The amino group is the electron supply group, which can increase the electron cloud density of the adjacent and para-site of the thiophene ring; methyl is also the power supply sub-group, which also affects the electron cloud distribution of the thiophene ring.
Overall, the chemical structure of this compound is: thiophene ring as the parent body, methylnitrile at the 3rd position, amino at the 2nd position, and methyl at the 5th position. The interaction of each group affects the physical and chemical properties of this compound. Methonitrile groups can participate in nucleophilic substitutions, amino groups can undergo acylation, alkylation and other reactions, while methyl groups are relatively stable, but under certain conditions, they can also participate in the reaction. With this structure, it may have potential application value in organic synthesis, pharmaceutical chemistry and other fields.

2 + -Amino-5-methyl-3-thiophenylcarbamonitrile is an organic compound with specific physical properties. Its appearance is often crystalline solid, and its color is mostly white to light yellow. This compound has good stability under normal conditions, and it is easy to initiate chemical reactions in case of high temperature, open flame or strong oxidants.
In terms of melting point, it is about 110 ° C - 115 ° C. As a material characteristic, the melting point is of great significance for its identification and purity determination. In this temperature range, the compound melts from a solid state to a liquid state, which helps to precisely control its state transition in experiments and production. < Br >
Solubility, slightly soluble in water, but soluble in common organic solvents, such as ethanol, dichloromethane, acetone, etc. This solubility characteristic determines its application in different solvent systems. In organic synthesis reactions, selecting a suitable organic solvent to dissolve this compound can effectively promote the reaction.
Its density is about 1.25 g/cm ³, which reflects the mass of the substance per unit volume. Density characteristics are key considerations in material measurement, separation, and mixing processes, and are important for accurate design and operation of related processes.
In addition, 2 + -amino-5-methyl-3-thiophenoformonitrile has a certain odor, but its odor is relatively weak and non-irritating, and usually does not cause strong discomfort to the human sense of smell. However, when handling this compound, safety practices should still be followed and it should be operated in a well-ventilated place to prevent potential health risks.

2 + -Amino-5-methyl-3-thiophenoformonitrile is widely used. In the field of medicinal chemistry, it is a key organic synthesis intermediate, and many drug development relies on it to build core structures. For example, when developing new therapeutic drugs for specific diseases, with its unique chemical structure, compounds with specific activities and targeting can be precisely designed and synthesized, which greatly promotes the birth of innovative drugs.
In the field of materials science, due to its special electronic properties and structure, it can be applied to the preparation of organic optoelectronic materials. Devices such as organic Light Emitting Diode (OLED) and organic solar cells can optimize material properties, improve device luminous efficiency, energy conversion efficiency and stability, and provide support for the development of high-performance organic optoelectronic devices.
In addition, in the field of agricultural chemistry, using 2 + -amino-5-methyl-3-thiophenoformonitrile as raw materials, new pesticides can be synthesized, such as insecticides, fungicides, etc. Its unique structure allows pesticides to exhibit efficient biological activity against harmful organisms, while being relatively friendly to the environment and non-target organisms, meeting the needs of modern green agriculture development. Overall, 2 + -amino-5-methyl-3-thiophenoformonitrile plays an important role in many fields and is of great significance for promoting technological innovation and development in related industries.

The method of synthesizing 2-amino-5-methyl-3-thiophenoformonitrile is not explicitly stated in Tiangong Kaiwu, but it can be deduced from the ancient chemical process ideas and similar synthesis methods.
The ancient chemical process depends on the selection of raw materials and the control of reaction conditions. To make this product, the choice of raw materials is quite critical. Find raw materials containing thiophene structure, amino group, methyl group and nitrile group. If a suitable thiophene derivative is used as the starting point, its structure may have a modifiable check point to introduce amino group, methyl group and nitrile group.
Introducing methyl group, the idea of similar alkylation can be borrowed from the ancient method. If halogenated methane and thiophene derivatives containing active check points are used in an appropriate medium, and a base is used as a catalyst to promote the methyl substitution reaction. This process requires attention to the properties of the medium. It is appropriate to choose the raw material that can dissolve and facilitate the reaction. The amount and type of base will also affect the reaction effect. The introduction of
amino groups may be analogous to the ancient amination reaction. React with ammonia or amine reagents with suitable substrates. If the thiophene derivative containing halogen atoms and ammonia are replaced by amino groups under high temperature and pressure or in the presence of a catalyst, the halogen atoms are replaced by amino groups to form thiophene products containing amino groups. In this process, the choice of temperature, pressure and catalyst is of paramount importance. High temperature can speed up the reaction rate, but if it is too high, it may cause more side reactions; suitable catalysts can reduce the activation energy of the reaction and improve the selectivity of the reaction.
The formation of nitrile groups can be reacted with substrates by cyanide-containing reagents. For example, halogenated thiophene derivatives and cyanide reagents such as sodium cyanide are reacted in a suitable solvent under the action of a phase transfer catalyst, and the halogen atoms are replaced by cyanide groups to obtain thiophene products containing nitrile groups. Phase transfer catalysts can promote full contact between the cyanide reagents in the aqueous phase and the substrates in the organic phase to improve the reaction efficiency.
During the reaction process, it is necessary to fine-tune the reaction conditions at each step, including temperature, time, After each step of the reaction, the product should be properly separated and purified to remove impurities and ensure the purity of the raw materials in the next step. In this way, although there is no certainty of "Tiangong Kaiwu", according to the ancient chemical ideas and processes, a way to synthesize 2-amino-5-methyl-3-thiophenecarbonitrile can be explored.

3-Thiophenoformonitrile, 2-Amino-5-methyl This substance involves many safety precautions and must be treated with caution.
It is chemically active and should be protected by the first person during operation. Be sure to wear complete protective clothing, including protective clothing, gloves and goggles, to prevent skin and eye contact. Because of its irritation, if you accidentally touch the skin, you should immediately rinse with plenty of water, followed by medical treatment; if you splash into the eyes, you should quickly rinse with plenty of water and rush to the medical office.
Furthermore, this substance may release harmful gases under specific conditions. Therefore, the operation should be placed in a well-ventilated place, preferably in a fume hood, to effectively disperse the harmful gases that may be generated and avoid inhalation. Once inhaled, if you feel uncomfortable, be sure to move to a fresh air place as soon as possible and seek medical attention in time.
In addition, storage should also be paid attention to. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, and protected from direct sunlight. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed to avoid dangerous chemical reactions.
During the handling process, the action should be gentle to prevent damage to packaging and containers. If a leak occurs accidentally, the personnel in the leaking contaminated area should be quickly evacuated to a safe area, and quarantined, and access should be strictly restricted. Emergency responders need to wear self-contained positive pressure breathing apparatus, wear anti-virus clothing, and cut off the source of leakage as much as possible. In the case of small leaks, it can be absorbed by sand, vermiculite or other inert materials; in the case of large leaks, it is necessary to build embankments or dig pits to contain them, cover them with foam to reduce vapor disasters, and then transfer them to a tanker or a special collector for recycling or transportation to a waste treatment site for disposal.
The operation of this substance must strictly follow the relevant safety procedures and operating guidelines, and must not be negligent, so as to ensure the safety of personnel and the environment.