3-methylthiophene-2-carboxylate

3-Methylthiophene-2-carboxylic acid ester, a genus of organic compounds. Its molecular structure contains a thiophene ring, with a methyl group at the 3rd position and a carboxylic acid ester group at the 2nd position. This unique structure endows it with various chemical properties.
When it comes to physical properties, under normal conditions, it is mostly liquid or solid, depending on the intermolecular forces and structural regularity. Its melting and boiling point is restricted by the intermolecular forces. Due to the presence of polar ester groups, the intermolecular forces are stronger, and the melting and boiling point is higher than that of some non-polar organic compounds.
In terms of solubility, because of its certain polarity, it has good solubility in polar organic solvents such as ethanol and acetone; in non-polar solvents such as n-hexane, it has poor solubility. This property is derived from the principle of similar phase solubility, and polar solutes are easily soluble in polar solvents.
Chemical properties are active, and the reaction of ester groups is first promoted. Hydrolyzable, under acidic or alkaline conditions, ester groups break bonds. Acidic hydrolysis slows to give 3-methylthiophene-2-carboxylic acid and alcohol; alkaline hydrolysis rate, to form carboxylate and alcohol, which is a saponification reaction class. Due to the alkaline environment, carbonyl carbons in ester groups are favored for nucleophilic substitution.
can also participate in the inverse process of esterification reaction, reaching esterification equilibrium with alcohol catalyzed by acid.
Furthermore, thiophene rings are aromatic and can undergo electrophilic substitution reactions. Because methyl is the power supply group, the electron cloud density of thiophene rings is increased, and the electrophilic substitution activity is increased. The substitution check point is mostly adjacent to or relative to the thiophene ring and methyl, such as halogenation, nitrification, sulfonation and other reactions.
In addition, 3-methylthiophene-2-carboxylic acid esters can be used as intermediates in organic synthesis. After a series of reactions, complex organic compounds are prepared, which are widely used in the field of drug and material synthesis.

3-Methylthiophene-2-carboxylic acid ester has a wide range of uses and has its own impact in many fields.
First, in the field of medicinal chemistry, it can be used as a key pharmaceutical intermediate. With the help of specific chemical reactions, it can be used as a starting material to synthesize a variety of drug molecules with specific biological activities. For example, in the synthesis of some therapeutic drugs for specific diseases, 3-methylthiophene-2-carboxylic acid esters are used as an important structural unit. Through a series of reactions, complex compounds with pharmacological activities are constructed, providing a key material basis for pharmaceutical research and development.
Second, in the field of materials science, it also plays an important role. It can be used to prepare functional materials, such as some organic optoelectronic materials. Due to its unique molecular structure, the material is endowed with specific electrical and optical properties, and is used in devices such as organic Light Emitting Diode (OLED) to improve its luminous efficiency, stability and other properties, and promote the development of display technology.
Furthermore, in the field of organic synthesis, 3-methylthiophene-2-carboxylate is an extremely important synthetic block. Chemists can use its activity check point to connect and modify it with other organic molecules through various organic reactions, such as esterification reaction, nucleophilic substitution reaction, etc., so as to construct organic compounds with diverse structures and rich functions, expand the boundaries of organic synthesis chemistry, and provide important basic raw materials for the creation of new compounds.

There are many ways to synthesize 3-methylthiophene-2-carboxylic acid ester. First, it can be obtained by esterification reaction of 3-methylthiophene-2-carboxylic acid and alcohol under the condition of acid catalysis. In this process, sulfuric acid, p-toluenesulfonic acid, etc. are often selected as catalysts. The reaction needs to be heated, and the water is removed with a water separator to promote the right balance of the reaction and improve the yield of the product. If 3-methylthiophene-2-carboxylic acid and ethanol are catalyzed by p-toluenesulfonic acid and heated for a number of refluxes, the corresponding ethyl ester can be obtained after post-treatment.
Furthermore, with 3-methylthiophene as the starting material, the target product can also be prepared by acylation reaction, the introduction of an acyl group at the 2-position of thiophene, and then oxidation, esterification and other steps. If acetyl chloride is used as the acylation reagent, under the catalysis of anhydrous aluminum trichloride, 3-methylthiophene is acylated to obtain 3-methyl-2-acetylthiophene, and then with a suitable oxidant, such as potassium permanganate, the acetyl group is oxidized to a carboxyl group, and finally esterified with an alcohol.
In addition, halogenated thiophene derivatives can also be synthesized as intermediates. First halogenate 3-methylthiophene to obtain halogenated 3-methylthiophene, and then carry out carbonylation and esterification reaction with carbon monoxide, alcohol in the presence of suitable catalysts (such as palladium catalyst) and bases to obtain 3-methylthiophene-2-carboxylate.
All synthesis methods have their own advantages and disadvantages. According to actual needs, consider the availability of raw materials, the difficulty of reaction conditions, the purity and yield of the product, and other factors, and choose carefully.

I have not heard of the exact price of 3-methylthiophene-2-carboxylate in the market. The name of this compound is little known in the market, or it is not widely used, and the price is difficult to determine. However, if you want its price, you can explore it in various chemical markets.
In today's world, the price of chemicals often varies depending on the source, purity, and quantity. If you buy it from a specialized chemical merchant, its price may fluctuate due to changes in supply and demand.
If you want to get the price of 3-methylthiophene-2-carboxylate, you can first find the chemical raw material market and online chemical trading platform. On the platform, the goods are listed by all merchants, and the prices are also different. Or due to different purity, high purity is expensive, and low is slightly cheaper; or due to the amount of purchase, the price may be given if the purchase volume is large.
If you are visiting the chemical raw material market, you can negotiate with various merchants to inquire about the upper and lower limits of their prices. Merchants may tell the approximate price according to market conditions and costs. However, this price is not constant, or changes from time to time, and the price of raw materials, freight, and taxes can all make the price rise and fall.
It is probably necessary to know the market price of 3-methylthiophene-2-carboxylate. When you are widely seeking merchants, you can get a more accurate price range by comparing its price. However, it is difficult for me to understand the range of the exact price, but I can only ask you how to ask for the price.

3-Methylthiophene-2-carboxylic acid ester is an important compound in the field of organic chemistry, which is widely used in many industries such as medicine, pesticides, materials, etc. As for its manufacturer, in today's world, many chemical companies are involved in the production of this compound.
In China, such as [specific manufacturer 1], this factory has a long-standing reputation, focusing on the field of fine chemicals for many years, with exquisite craftsmanship and excellent equipment. The 3-methylthiophene-2-carboxylic acid ester produced is of high quality and is widely praised in the market. There is also [specific manufacturer 2], which is also a leader in the industry. Leading by technological innovation, it continuously optimizes the production process. The quality of the products produced is stable, the supply capacity is quite strong, and it is sold domestically and also exported.
Overseas, [specific manufacturer 3] is also well-known. Its technical heritage is profound, and it occupies a place in the global chemical market. The compounds produced are famous for their high purity and excellent performance. In addition, [specific manufacturer 4], with its advanced management model and strict quality control, its products sell well in the international market and are a high-quality supplier to many well-known enterprises. < Br >
All these manufacturers are committed to the pursuit of excellent quality and to meeting market demand. They continue to promote the production and application of 3-methylthiophene-2-carboxylate.