3 Methylthiophene 2 Boronic Acid
quinoline thiophene imidazole thiazole

3-Methylthiophene-2-boronic acid

Taiy Chemical

    Specifications

    HS Code

    768583

    Chemical Formula C5H7BO2S
    Molar Mass 141.99 g/mol
    Appearance Solid
    Color White to off - white
    Solubility In Water Poor
    Solubility In Organic Solvents Soluble in some organic solvents like dichloromethane
    Melting Point 116 - 120 °C
    Purity Typically high - purity products around 97%+
    Stability Should be stored in a dry and cool place, moisture - sensitive

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    General Information
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    Frequently Asked Questions

    As a leading 3-Methylthiophene-2-boronic acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main application fields of 3-methylthiophene-2-boronic acid
    3-Methylglutaric acid-2-ketoacid, a substance that has attracted much attention in the field of organic compounds, has shown important value in many key application fields.
    In the field of medicinal chemistry, it is a key intermediate for the synthesis of specific drugs. With this compound, molecular structures with specific biological activities can be cleverly constructed. In the process of many innovative drug development for neurological diseases and cardiovascular diseases, 3-methylglutaric acid-2-ketoacid plays a cornerstone role, enabling chemists to precisely design and synthesize drug molecules that meet therapeutic needs, adding to human health and well-being.
    In the field of biochemical research, it occupies an important position in the study of cellular metabolic pathways. As a key node product or substrate of some metabolic pathways, in-depth exploration of the metabolic reaction mechanism in which it participates will help scientists gain a comprehensive understanding of core physiological processes such as cellular energy metabolism and material transformation. By clarifying its role in the metabolic network, it can further elucidate the intrinsic mechanism of biological growth, development and response to external stimuli, providing key clues for basic research in life sciences.
    In the field of organic synthesis, its unique chemical structure endows it with rich chemical reaction activities. Chemists can use its special functional groups to carry out various organic reactions, such as nucleophilic addition, oxidation and reduction, etc., to construct complex and diverse organic compounds. This provides a wealth of strategies and methods for the synthesis of natural products, new materials, etc., promoting organic synthetic chemistry to new heights and expanding the boundaries of human creation and application of organic substances.
    What are the synthesis methods of 3-methylthiophene-2-boronic acid?
    The synthesis methods of 3-methylindole-2-carboxylic acid, also known as skatole-2-carboxylic acid, are quite diverse, and the following are described in detail by Jun.
    First, indole-2-carboxylic acid is used as the starting material and can be prepared by methylation. First, the indole-2-carboxylic acid is dissolved in a suitable organic solvent, such as N, N-dimethylformamide (DMF), and a base, such as potassium carbonate, is added. Stir well. Then slowly add a methylating agent, such as iodomethane, and react at a suitable temperature. In this process, the alkali captures the hydrogen of indole-2-carboxylic acid to generate carbon anion, and then undergoes nucleophilic substitution reaction with iodomethane to obtain 3-methylindole-2-carboxylic acid. After the reaction, the product is purified by extraction, washing, drying, column chromatography and other operations.
    Second, start from o-aminobenzoic acid. First condensate with pyruvate to form 2- (2-carboxyphenyl) -4-methyl-5-oxo-4,5-dihydrooxazole-3-onium inner salt, which is the key intermediate. Then, under the catalysis of acid, an intramolecular cyclization reaction occurs to rearrange to form 3-methylindole-2-carboxylic acid. After the reaction, the product is purified by adjusting the pH value, filtering, recrystallization and other steps.
    Third, 3-methylindole is used as raw material and prepared by carboxylation reaction. 3-methylindole is dissolved in a suitable solvent, such as tetrahydrofuran (THF), and a strong base, such as n-butyl lithium, is added at low temperature to form a lithium salt. Subsequently, carbon dioxide gas is introduced and a carboxylation reaction occurs to obtain 3-methylindole-2-carboxylic acid. After the reaction is completed, the pure product is obtained through acidification, extraction, drying, crystallization and other steps.
    The above methods have advantages and disadvantages. In actual synthesis, it is necessary to comprehensively consider factors such as raw material availability, reaction conditions, yield and purity requirements, and choose the optimal synthesis path.
    What are the physical and chemical properties of 3-methylthiophene-2-boronic acid?
    3-Methylglutaric acid-2-ketoacid is one of the organic compounds. Its physical and chemical properties are unique and worth exploring.
    First of all, its physical properties. At room temperature, this substance is mostly solid, or white crystalline powder with fine texture. Its melting point is within a specific range, which can help identify and purify. Due to the molecular structure, the solubility varies in common organic solvents. In polar organic solvents such as ethanol, the solubility is relatively high, while in non-polar solvents such as n-hexane, the solubility is very low. This solubility difference has important applications in separation and extraction processes.
    Re-describe its chemical properties. The presence of active functional groups such as carbonyl and carboxyl groups in this compound endows it with rich chemical reactivity. Carbonyl groups can undergo addition reactions, such as reactions with nucleophiles such as alcohols, to generate acetal or semi-acetal products. This reaction is often used in organic synthesis to protect carbonyl groups or build complex organic molecular structures. Carboxyl groups are acidic and can neutralize with bases to form corresponding carboxylic salts. In addition, due to the interaction of neighboring functional groups, this substance may also undergo some special reactions, such as intracellular rearrangements under certain conditions to generate products with different structures. Due to its unique physical and chemical properties, 3-methylglutaric acid-2-keto acid is widely used in the field of organic synthesis and can be used as a key intermediate for the synthesis of many bioactive compounds, contributing to the development of medicine and materials science.
    What are the precautions for 3-methylthiophene-2-boronic acid during storage and transportation?
    3-Methylpyridine-2-carboxylic acid should pay attention to the following things during storage and transportation:
    First, this material has specific chemical activity and should be avoided from coexisting with strong oxidants, strong acids and strong bases. Because of strong oxidants, it may cause severe oxidation reactions, triggering the risk of combustion or even explosion; contact with strong acids and strong bases can also promote chemical reactions, causing changes in composition and properties, damaging its quality and use.
    Second, the control of temperature and humidity is crucial. It should be stored in a cool, dry place, away from heat and fire sources. High temperature can accelerate the volatilization of 3-methylpyridine-2-carboxylic acid, or even cause decomposition; high humidity environment can easily make it absorb moisture, or cause agglomeration and deterioration. For example, if it is placed in a corner of a warehouse with high temperature and humidity in summer, this situation is prone to occur.
    Third, the packaging must be tight and reliable. To prevent leakage, because 3-methylpyridine-2-carboxylic acid may be irritating and corrosive, leakage not only causes material loss, but also endangers the surrounding environment and personnel safety. During transportation, it is also necessary to ensure that the packaging is intact and free from vibration and collision.
    Fourth, the storage and transportation place should be well ventilated. This can disperse possible volatile gases in time, reduce the concentration of harmful substances in the air, prevent their accumulation to dangerous levels, and reduce the risk of explosion and poisoning.
    Fifth, handle with care. Avoid brutal loading and unloading to prevent package damage. Staff should also take necessary protective measures, such as protective clothing, gloves and goggles, to avoid direct contact with 3-methylpyridine-2-carboxylic acid.
    What is the market price of 3-methylthiophene-2-boronic acid?
    3-Methylpyridine-2-carboxylic acid, the price in the market, roughly how much? This is a genus of fine chemicals, and the change in its price is related to various reasons.
    First, the price of raw materials. To make this 3-methylpyridine-2-carboxylic acid, the price of the raw materials used is constant. If the production of raw materials is less and more, the price will be high, and the price of this 3-methylpyridine-2-carboxylic acid will also rise. On the contrary, if the raw materials are abundant and less, the price may decline.
    Second, the process is simple. If the method of making is difficult, requires exquisite equipment, exquisite skills, or more labor hours, the cost will increase, and the price in the market will also be high. If the process is simple, the cost will be reduced, and the price may also be reduced.
    Furthermore, the supply and demand of the city. If there are many people in the market who want 3-methylpyridine-2-carboxylic acid, and there are few suppliers, the price will be increased. If the supply exceeds the demand, merchants will sell their goods, or cut the price to sell.
    There is also a difference in quality. Those with excellent quality meet the standard of strict regulations, and the price is often higher than that of the next one.
    Roughly speaking, the current price of 3-methylpyridine-2-carboxylic acid in the market is only approximate. Market conditions are irregular, and the price may be high and low. If you want to know the exact price, you must carefully observe the current market and consult the merchant.