3-(methylsulfanyl)thiophene

3- (methylthio) thiophene is one of the organic compounds with a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate.
First, in the field of medicinal chemistry, 3- (methylthio) thiophene can be used as a starting material. After a series of chemical reactions, biologically active drug molecules can be prepared. Due to its special structure, it can endow the prepared drugs with specific pharmacological properties, such as affinity for specific targets, which is expected to develop new drugs for the treatment of specific diseases.
Second, in materials science, this compound can participate in the synthesis of polymer materials. After polymerization with other monomers, materials with unique electrical, optical or mechanical properties can be prepared. For example, in the field of organic optoelectronic materials, it may improve the charge transport capacity of materials, thereby improving the performance of organic Light Emitting Diodes (OLEDs) or organic solar cells.
Furthermore, in the production of fine chemicals, 3- (methylthiophene) thiophene is also indispensable. In the preparation of fine chemicals such as fragrances and pesticides, it can be used as an important synthetic building block. Through clever chemical transformation, specific functional groups are introduced to achieve the desired chemical structure and functional characteristics.
In addition, in terms of scientific research and exploration, as an important raw material for organic synthesis, scientists can expand the understanding of the reaction mechanism of organic chemistry by conducting various reaction studies, develop novel synthesis methods, and contribute to the development of organic synthetic chemistry. In short, 3- (methylthiophene) thiophene is of great value in many fields and is of great significance for promoting the progress of related science and technology.

3- (Methylthiophene) thiophene is an organic compound with special physical properties. Let me tell you one by one.
Its appearance is liquid. Under normal temperature and pressure, it may be a clear liquid. The color may be nearly colorless or very light. This color is quite common in organic liquids and is easy to observe and identify.
The characteristics of boiling point are of great significance for its separation, purification and application. Its boiling point is specific. If you want to separate it from the mixture, you can achieve it by distillation according to the difference in boiling point. This boiling point value is the temperature at which it changes from liquid to gaseous state under a specific air pressure, allowing us to control its phase transition. It is an important parameter in chemical production and laboratory operations.
Solubility is also a key physical property. 3- (methylthiophenyl) thiophene has good solubility in organic solvents, such as common organic solvents such as ethanol and ether, and can dissolve with it. This property is due to the interaction between its molecular structure and the molecules of the organic solvent, so that the two can be uniformly mixed. However, the solubility in water is poor, because its molecular polarity is quite different from that of water. Water is a strong polar solvent, and the polarity of the compound is weak, following the principle of "similar miscibility", so it is difficult to dissolve in water.
In addition, density is also one of its physical properties. Its density is specific, and it is either greater than or less than water compared with water. This property is of great significance when it involves operations such as liquid-liquid separation. If its density is greater than that of water, it will be in the lower layer in the stratification phenomenon; otherwise, it will be in the upper layer, and related separation operations can be carried out accordingly.
In summary, the physical properties of 3 - (methylthio) thiophene, such as appearance, boiling point, solubility and density, are of great value for its identification, separation and application, and are indispensable in the research and production of organic chemistry and related fields.

3- (methylthio) thiophene is a member of the family of organic compounds with unique chemical properties. This substance is composed of a thiophene ring and a specific substituent group, and the methylthio group is connected to the third position of the thiophene ring.
In terms of physical properties, 3- (methylthio) thiophene is liquid at room temperature and has a certain volatility and emits a special odor. Its solubility is different from other substances. It is soluble in organic solvents such as ethanol and ether, but it has poor solubility in water. This characteristic is due to the influence of hydrophobic groups in its molecular structure.
In terms of chemical properties, the thiophene ring of 3- (methylthio) thiophene is an electron-rich system with aromatic properties, which gives it unique reactivity. It can participate in electrophilic substitution reactions, and methylthio groups are the power supply groups, which can increase the electron cloud density of the thiophene ring, especially the ortho and para-positions, so electrophilic reagents are prone to attack these two positions. For example, during halogenation reactions, halogen atoms tend to be attached to the positions adjacent or opposite to the thiophene ring and the methylthio group.
In addition, the sulfur atoms of 3- (methylthio) thiophene are also reactive and can participate in oxidation reactions. They can be oxidized to sulfoxides or sulfones by different oxidants. Under appropriate conditions, it can also react with metal-organic reagents to form new carbon-sulfur bonds or carbon-carbon bonds, which are widely used in the field of organic synthesis and can be used to prepare various organic compounds such as drugs and materials.

To prepare 3- (methylthio) thiophene, the regular number method is used. First, thiophene is used as a group to combine it with methyl thio-chloride under suitable reaction conditions according to the mechanism of nucleophilic substitution. Among them, the electron cloud density distribution on the thiophene ring is similar, the electron cloud density of the ortho-position of the sulfur atom is higher, and the chlorine atom of the methyl thio-chloride has good leaving property. The two contact and form 3- (methylthio) thiophene through the process of attack by nucleophiles and separation of the leaving group. The reaction requires the selection of appropriate solvents, such as aprotic polar solvents, to promote the dissolution and ionization of the reactants, and the temperature needs to be controlled to avoid side reactions. < Br >
Second, it can be started from sulfur-containing organic precursors. For example, a specific thiolenone-containing compound is used as the starting material and obtained by intramolecular cyclization. Under the action of a suitable catalyst, the carbon-carbon double bond and sulfur-containing functional group of enolenones undergo cyclization and rearrangement to construct a thiophene ring, and then a methyl-sulfur group is introduced. In this process, the choice of catalyst is essential, and its activity and selectivity affect the efficiency and product purity of the reaction.
Third, the coupling reaction catalyzed by transition metals. Halogenated thiophene and methylthio-based reagents are used as raw materials, and transition metals such as palladium and nickel complexes are used as catalysts. With the help of ligands, the target product is obtained through oxidative addition, metal transfer, reduction and elimination in the presence of bases. This approach requires harsh reaction conditions. Metal catalysts need to be precisely regulated in dosage and activity, and the type and dosage of bases also affect the reaction process. Each method has its advantages and disadvantages. In actual preparation, it needs to be weighed against many factors such as raw material availability, cost, and product purity.

I don't know the price range of 3- (methylthio) thiophene in the market. This compound is used in chemical, pharmaceutical, materials and other fields. Its price often varies due to many factors such as quality, purity, market supply and demand.
If the purity is ordinary, it is not a special high purity or special grade. In the chemical raw material market, when purchasing in large quantities, the price per kilogram may be in the hundreds of yuan. However, if it is used in pharmaceutical research and development and other places with strict purity requirements, the price of high-purity 3- (methylthio) thiophene may reach tens of yuan per gram or even higher.
Market supply and demand are also key. If there is a large increase in demand for it at a certain time, and the supply is limited, the price will rise; conversely, if the supply is sufficient and the demand is not strong, the price may drop. The difficulty of the production process and the fluctuation of the cost of raw materials will affect the price. In order to determine the exact price range, it is necessary to carefully observe the current market conditions and consult the chemical raw material suppliers, traders and other industry personnel to obtain a more accurate price.