3-Iodothiophene-2-carboxylic acid

3-Iodothiophene-2-carboxylic acid, this substance has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate. The structure of Geiinthiophene has unique electronic properties and biological activity, and the introduction of iodine atoms can increase molecular reactivity and selectivity. Through a series of organic reactions, such as coupling reactions, it can be combined with other compounds containing specific functional groups to create complex and diverse drug molecules, or used to develop antibacterial and anti-tumor drugs, contributing to medical progress.
It also has important applications in the field of materials science. It can be chemically modified to participate in polymerization reactions to build new functional polymer materials. Due to the presence of iodine atoms, it can affect the electrical and optical properties of materials. It is expected to prepare materials with special optoelectronic properties, such as used in organic Light Emitting Diodes (OLEDs) or organic photovoltaic cells, to improve device efficiency and performance, and to promote innovation and development in the field of materials science.
In addition, in organic synthetic chemistry, 3-iodothiophene-2-carboxylic acid is an important starting material, providing the possibility for the synthesis of many complex organic compounds. Chemists can use various synthesis strategies based on their structural characteristics to expand the molecular framework and introduce different functional groups to achieve precise regulation of the structure and properties of the target product, enriching the content and means of organic synthetic chemistry.

3-Iodothiophene-2-carboxylic acid, is a kind of organic compound. It has the following physical properties:
This substance is mostly solid at room temperature, and the color state is white to light yellow crystalline powder, which is fine in appearance. As for the melting point, the melting point is about 155-159 ° C. At this temperature, it gradually melts from solid to liquid, and the intermolecular force changes. However, accurate data on the boiling point are difficult to find. Because it is heated or decomposed first, it can be inferred that its boiling point is quite high. Due to the presence of sulfur atoms, iodine atoms and carboxyl groups in the molecule, many strong interactions are formed. To make it boil and gasify, more energy needs to be supplied. In terms of solubility, it exhibits a certain solubility in common organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF). In dichloromethane, because of its molecular structure and dichloromethane, it is partially soluble; in DMF, the polarity of DMF can interact with the polar group of 3-iodothiophene-2-carboxylic acid, and the solubility is better. However, in water, due to the existence of hydrophobic thiophene ring and iodine atom, the solubility is very small, and only a very small amount can be dispersed.
The density is relatively large compared with water, and if mixed with water, it will sink to the bottom of the water. Due to the large relative atomic weight of iodine atoms in the molecule, its unit volume mass is heavier. In addition, it has a certain odor, or a special organic odor, but the relevant odor description data is limited, and your mileage may vary.
The physical properties of this compound are closely related to its molecular structure. The thiophene ring gives it a certain aromaticity, the iodine atom affects its polarity and quality, and the carboxyl group makes the molecule acidic and hydrophilic. However, the overall properties are still formed by the comprehensive action of each group.

The synthesis method of 3-iodothiophene-2-carboxylic acid has been known for a long time. This wonderful method is briefly described as follows.
First, thiophene-2-carboxylic acid is used as the starting material. First, thiophene-2-carboxylic acid is combined with an appropriate amount of iodine reagent, such as iodine elemental (I _ 2) and a suitable oxidant, such as hydrogen peroxide (H _ 2O _ 2) or periodate (HIO _), etc., in a suitable solvent, such as glacial acetic acid or dichloromethane, and reacts under certain temperature conditions. In this process, the iodine reagent introduces iodine atoms into the third position of the thiophene ring with the help of an oxidizing agent to obtain 3-iodothiophene-2-carboxylic acid. During the reaction, temperature control is extremely important. If the temperature is too high, side reactions are easy to occur and the product is impure. If the temperature is too low, the reaction is slow and time-consuming.
Second, thiophene can be used as the starting material. First, thiophene is carboxylated, often with carbon dioxide (CO 2) as the carboxyl source. Under the action of strong bases such as n-butyl lithium (n-BuLi), thiophene-2-carboxylic acid is formed. Then, according to the above method, the thiophene-2-carboxylic acid is iodized to achieve the synthesis of 3-iodothiophene-2-carboxylic acid. This path has a little more steps, but the raw material thiophene is common and easy to obtain, and it is also a commonly used method.
Third, 3-halogenated thiophene-2-carboxylic acid derivatives are used as raw materials. If it is 3-bromothiophene-2-carboxylic acid, a halogen exchange reaction can be used with iodizing reagents, such as potassium iodide (KI), etc., in the presence of catalysts, such as copper salts (CuI, etc.), in an appropriate solvent, such as N, N-dimethylformamide (DMF). The bromine atom is replaced by an iodine atom to obtain the target product 3-iodothiophene-2-carboxylic acid. This reaction requires attention to the amount of catalyst and the reaction time to achieve a good reaction effect.
All synthesis methods have their own advantages and disadvantages, and they need to be carefully selected according to the actual situation, such as the availability of raw materials, cost, product purity requirements, etc., in order to get twice the result with half the effort.

I have checked the "Tiangong Kaiwu", which does not contain the price of "3 - Iodothiophene - 2 - carboxylic acid". This is a modern chemical substance. "Tiangong Kaiwu" was formed in the Ming Dynasty, when chemical development did not reach this point. However, if you want to know the price range of this product on the market, you can find it on the chemical raw material trading platform and chemical reagent suppliers today.
Generally speaking, its price is affected by purity, packaging specifications, purchase volume and market supply and demand. If the purity is high, such as high-purity products used in high-end scientific research, the price will be expensive; if the low purity is used for general experimental or industrial primary applications, the price will be slightly lower. If the packaging specifications are large, the unit price may be discounted. If the purchase quantity is large, you can also enjoy discounts.
In the current market, according to past prices of similar organic compounds, the price of small packaging (such as 5 grams) of low purity (about 90%) products may be around 100 yuan; if it is high purity (more than 98%) and small packaging, the price may be hundreds of yuan. If the purchase quantity reaches the kilogram level, the low purity is per kilogram or several thousand yuan, and the high purity is per kilogram or more than 10,000 yuan. However, this is only a rough guess, and the actual price shall be subject to the quotation of each supplier.

3-Iodothiophene-2-carboxylic acid is an organic compound, and its storage conditions are quite important, which is related to the stability and quality of this compound.
Store this compound in a dry environment. Because of its certain hygroscopicity, if the storage environment humidity is high, it is easy to absorb water and cause quality deterioration. Therefore, it should be placed in a dry place, such as a dryer equipped with a desiccant, to keep it dry.
Temperature is also a key factor. Generally speaking, it should be stored in a cool place, generally 2-8 ° C. Too high temperature may cause reactions such as decomposition and deterioration of the compound, which will damage its chemical properties.
Storage in the dark is also indispensable. This compound may be sensitive to light, under light, or cause photochemical reactions, resulting in structural changes and loss of activity. Therefore, it should be stored in dark containers such as brown bottles to prevent the influence of light.
The choice of storage containers also needs to be considered. Containers made of glass or specific plastic materials should be used to ensure that the containers are well sealed to prevent the intrusion of air, water vapor, etc. from affecting the purity and stability of the compound.
And the storage place should be kept away from fire sources, heat sources and strong oxidants to avoid dangerous chemical reactions. When taking it, strict operating procedures should also be followed to prevent contamination and ensure the consistent quality of the compound. In this way, 3-iodothiophene-2-carboxylic acid can be properly stored to maintain its original properties and functions.