3-Chlorobenzothiophene-2-carboxaMide

3-Bromopropenofuranone has a specific structure and is often a key intermediate in various organic synthesis. As for the chemical structure of α-chloroacrylic acid, it is ingeniously structured from carbon, hydrogen, oxygen and chlorine elements.
The main body of α-chloroacrylic acid is based on the structure of acrylic acid. Acrylic acid has a vinyl group attached to a carboxyl group. And α-chloroacrylic acid, that is, on the α-position carbon of acrylic acid, a chlorine atom is used instead of a hydrogen atom. This substitution gives it different chemical properties.
Its chemical formula is C 🥰 H 🥰 ClO 🥰, and its molecular weight is about 106.51. Looking at its structure, it can be regarded as the hydrogen atom connected to the carbon atom at the alpha position adjacent to the carboxyl group in the acrylic acid molecule, which is easily replaced by the chlorine atom. This structural change makes the electron cloud distribution of alpha-chloroacrylic acid different from that of acrylic acid, and then the reaction activity is different.
The chlorine atom has electron-absorbing properties, which will reduce the electron cloud density of the alpha position and enhance the acidity of the carboxyl group. And because of the presence of chlorine atoms, this molecule exhibits a unique reaction path in nucleophilic substitution and addition reactions. In nucleophilic substitution reactions, chlorine atoms are easily replaced by nucleophilic reagents; in addition reactions, double bonds are active. The structure of α-chloroacrylic acid is unique due to the substitution of chlorine atoms. It is often an important starting material for the creation of new compounds in the field of organic synthesis, and is of great significance for the preparation of many fine chemicals.

Borax is the crystallization of mineral borax, which has a wide range of uses.
In the field of medicine, borax has the functions of clearing away heat and detoxifying, reducing swelling and preventing corrosion. "Compendium of Materia Medica" says: "Borax, sweet taste, slightly salty, cool in nature, non-toxic." It is often used to treat sore throat, sores on the mouth, red eyes and other diseases. For example, Bingboron powder in "Authentic Surgical", which is combined with borax borneol, cinnabar, Xuanming powder and other medicines, can treat sore throat and mouth. When used externally, borax can clean the sore surface, inhibit the growth of bacteria, and help wounds heal.
In industry, borax is an important raw material for making glass and ceramics. In the production of glass, the addition of borax can increase the thermal stability and transparency of the glass, making it more resistant to wear and chemical corrosion. In ceramic production, borax can reduce the melting point of ceramics, improve their molding properties, and enhance the luster and hardness of ceramics.
In the food industry, borax was often used as a food additive in the past, which can increase food toughness, brittleness, and preservative preservation. However, due to its strong toxicity, excessive intake of borax can endanger human health, and it is now strictly prohibited to use it in food processing.
In the field of alchemy, according to ancient books such as "Baopuzi Nei", borax may be used as an auxiliary material in the process of alchemy to help adjust the temperature and chemical reactions of alchemy refining. However, it should be noted that ancient alchemy contained many superstitious and unscientific ingredients, among which the raw materials and methods used in medicinal pills may pose great risks.
Although borax has various uses, its toxicity cannot be underestimated. It should be used with caution and follow relevant norms and standards.

Lead pill, also known as red pill and yellow pill, is a common thing in ancient alchemy, and its chemical composition is lead trioxide ($Pb_3O_4 $). Lead pill has many physical properties, as detailed below:
- ** Appearance **: Lead pill presents a bright orange-red powder, with a dazzling color and a very bright appearance. This color characteristic makes it often used as a pigment in ancient times, used in painting, finishing utensils, etc., adding brilliant color to many artistic creations and craft products.
- ** Texture **: The powder is fine in texture, soft to the touch, and the particles are uniform and fine. Touch it with your hand and you can feel a slippery feeling, like fine sand, but it is softer. < Br > - ** Density **: Lead Dan has a higher density and is heavier in the same volume than ordinary substances. This property is related to the relatively large atomic weight of lead, which makes lead Dan in practical applications. If it is used in specific scenarios, its weight factor needs to be considered.
- ** Solubility **: Lead Dan is insoluble in water. If it is placed in water, the powder will be suspended in water and gradually settle at the bottom after a period of time, without dissolving and mixing with water. However, it is soluble in acid, and when exposed to acid, it will chemically react to form corresponding lead salts and other products. < Br > - ** Stability **: Under normal conditions of normal temperature and pressure, lead Dan has certain stability and can maintain its own chemical structure and physical form for a long time. However, under extreme conditions such as high temperature and strong oxidation, its chemical properties will change and participate in various chemical reactions.

The synthesis of tetramethylchlorothiazide has various methods, each of which has its own needs. The details are as follows:
First, it starts with o-chlorobenzoic acid and is chlorinated with acyl to obtain o-chlorobenzoyl chloride. Following the condensation with 2-amino-6-chlorobenzothiazide-7-sulfonamide, this step requires a suitable temperature and a catalyst, such as in the presence of an acid binding agent, to react the two to obtain the target methylchlorothiazide. The raw materials in this way are easy to obtain, but the reaction steps are slightly more complicated, requiring fine temperature control and reaction process to preserve yield and purity.
Second, starting from 2-chloro-5-aminosulfonylbenzoic acid, the ring is closed first to form benzothiadiazine, and then chlorination is introduced into the chlorine atom at a specific position, and methylchlorothiazide can also be obtained. The key to this process lies in the closed-loop reaction conditions, and the appropriate solvent and reaction time need to be selected. The chlorination step also needs to be precisely controlled to prevent side reactions from generating and resulting in impure products.
Third, with m-chloroaniline as the starting material, through a series of transformations such as diazotization and Sandmeier reaction, the benzothiadiazine parent nucleus is constructed, and then the desired substituent is introduced. Although this path can be cleverly constructed, reactions such as diazotization are dangerous and require high operation, and attention should be paid to the stability and treatment of reaction intermediates.
All synthesis methods have their own advantages and disadvantages. In practical applications, according to the availability of raw materials, cost, equipment conditions and product quality requirements, careful selection can be used to optimize the production of methylchlorothiazide and meet the needs of medicine and other fields.

In today's market, the price of methyl mercaptan varies according to its quality, quantity, supply and demand.
Ordinarily speaking, methyl mercaptan in the market is mostly used for industrial purposes, and its price ranges from thousands to more than 10,000 per ton. If the quality is high and the quantity is large, or due to the effect of scale, the price may reach the lower limit; if the quality is thin and the supply is small and the demand is large, the price will tend to be higher.
However, the market is unstable, and the price also changes with market conditions. If the price of raw materials rises and falls, the difficulty of production is easier, and the regulation of policies is available, the price of methyl mercaptan can fluctuate. In order to know the exact price, it is necessary to check the market situation and consult the industry from time to time.