3-chloro-6-fluoro-N- chemical structure of [4- (morpholin-4-yl) phenyl] -1-benzothiophene-2-carboxamide

This is the problem of chemical structure analysis of organic compounds. 3 - chloro - 6 - fluoro - N - [4 - (morpholin - 4 - yl) phenyl] - 1 - benzothiophene - 2 - carboxamide, according to its name, its structure can be analyzed step by step.

"3 - chloro" shows that there is a chlorine atom substitution at the 3rd position of the main structure. "6 - fluoro", the 6th position of the table has a fluorine atom substitution. " 1-Benzothiophene-2-carboxamide ", it can be seen that the main structure is 1-benzothiophene-2-formamide. Benzothiophene is a structure formed by fusing a benzene ring with a thiophene ring, and the formamide group is connected to the second position of the thiophene ring.

" N - [4- (morpholin-4-yl) phenyl] "indicates that the nitrogen atom is connected to a phenyl group, and the fourth position of the phenyl group is connected with a 4-morpholinyl group. The morpholinyl group is a six-membered heterocyclic structure containing an oxygen atom and a nitrogen atom.

In summary, the chemical structure of this compound is 1-benzothiophene-2-formamide as the main body, with chlorine atom at the 3rd position and fluorine atom at the 6th position, and the nitrogen atom of the formamide group is connected to a 4-morpholinyl phenyl group. In this way, its chemical structure can be clarified.

What are the main uses of 3-chloro-6-fluoro-N- [4- (morpholin-4-yl) phenyl] -1-benzothiophene-2-carboxamide?

3 - chloro - 6 - fluoro - N - [4 - (morpholin - 4 - yl) phenyl] - 1 - benzothiophene - 2 - carboxamide is an organic compound. Looking at the structure of this compound, its main use may be related to the field of medicinal chemistry.

In the process of pharmaceutical creation, such compounds containing specific functional groups are often key materials for the development of new drugs. For example, the structure of benzothiophene is common in many drug molecules, or endows the compound with unique biological activities, such as the function of regulating specific biological targets.

The introduction of chlorine and fluorine atoms and halogen atoms can significantly change the physical and chemical properties of compounds, such as fat solubility, stability, etc., which in turn affect their absorption, distribution, metabolism and excretion in vivo. The N - [4 - (morpholin - 4 - yl) phenyl] part may interact with the activity check point of specific biological macromolecules, presenting potential pharmacological activities, such as inhibition of specific enzymes or regulation of receptors.

Or also used in the field of materials science. Due to the uniqueness of its structure, materials with special properties, such as photoelectric materials, can be prepared by specific processes. The characteristics of electron cloud distribution in its structure may make the material exhibit unique optical and electrical properties, which have come to the fore in the development of organic Light Emitting Diodes, sensors and other devices.

However, this is only based on its structural characteristics, and the practical use still needs a lot of experimental research and data support to understand its specific functions in various fields.

3-chloro-6-fluoro-N- [4- (morpholin-4-yl) phenyl] -1-benzothiophene-2-carboxamide

To prepare 3-chloro-6-fluoro-N- [4- (morpholine-4-yl) phenyl] -1-benzothiophene-2-formamide, the method of organic synthesis is often followed.

First, you need to prepare benzothiophene derivatives, fluorochlorine-containing reagents, 4- (morpholine-4-yl) aniline and other raw materials.

One method is to chlorinate and fluorinate benzothiophene first. In a suitable solvent, such as dichloromethane or N, N-dimethylformamide (DMF), a catalyst, such as anhydrous aluminum trichloride, etc., a chlorinated reagent, such as thionyl chloride, is blended with benzothiophene, heated and stirred to promote chlorination. Then, in a similar way, a fluorinated reagent, such as potassium fluoride, undergoes a fluorination step to obtain 3-chloro-6-fluoro-1-benzothiophene derivatives.

Subsequently, N - [4 - (morpholine-4-yl) phenyl] moiety is prepared. 4-Chloroaniline is reacted with morpholine in an alkaline environment, such as potassium carbonate, in a suitable solvent (e.g. acetonitrile) to produce 4- (morpholine-4-yl) aniline.

Finally, 3-chloro-6-fluoro-1-benzothiophene-2-carboxylic acid is activated, such as by conversion to acyl chloride, and treated with oxalyl chloride or dichlorosulfoxide. Then react with 4- (morpholine-4-yl) aniline in the presence of a base (such as triethylamine) in a solvent (such as dichloromethane) to obtain the target product 3-chloro-6-fluoro-N - [4 - (morpholine-4-yl) phenyl] -1 -benzothiophene-2-formamide. After the reaction is completed, it is purified by extraction, column chromatography, etc., to obtain a pure product.

What are the physical and chemical properties of 3-chloro-6-fluoro-N- [4- (morpholin-4-yl) phenyl] -1-benzothiophene-2-carboxamide

3-Chloro-6-fluoro-N - [4- (morpholine-4-yl) phenyl] - 1-benzothiophene-2-formamide, this is an organic compound. Its physical and chemical properties are unique, let me tell you in detail.

Looking at its properties, under normal temperature and pressure, it is mostly solid or powdery, and its color is often near white or off-white. Due to the arrangement and combination of atoms in the molecular structure, its external morphology is so stable.

When it comes to solubility, this substance may behave differently in organic solvents. In some polar organic solvents, such as dimethyl sulfoxide (DMSO), its solubility is acceptable. The polarity of DMSO is compatible with some groups of the compound, and the intermolecular force promotes the two to melt. However, in water, its solubility is low. The polarity of edge water is quite different from the overall polarity of the compound, and the proportion of hydrophobic groups in the molecule is large, which hinders its interaction with water molecules.

In terms of melting boiling point, the compound has a certain melting point. The level of this melting point is determined by the intermolecular force. The hydrogen bonds and van der Waals forces in the molecules make the molecules bind each other, and a specific energy is required to break this binding and realize the transformation of the state of matter. The specific melting point value varies depending on the purity of the compound and the test conditions, but it is roughly within a certain range. < Br >
In addition to its chemical stability, under general conditions, the compound is relatively stable. The structure of benzothiophene ring and amide bond in the molecule endows it with certain stability. However, under strong acid, strong base environment, or high temperature and strong redox conditions, its structure may be destroyed. Amide bonds in strong acid or strong base solution, or hydrolysis reaction occurs, resulting in molecular structure changes.

In terms of spectral properties, the compound has corresponding absorption peaks for each characteristic group in the infrared spectrum. For example, the carbonyl group of the amide bond has obvious absorption at a specific wave number, which can be used to identify the existence and structure confirmation of the compound. In NMR spectra, hydrogen and carbon atoms in different chemical environments exhibit unique chemical shifts, providing key information for the analysis of their molecular structures.

This is a summary of the physicochemical properties of 3-chloro-6-fluoro-N - [4 - (morpholine-4-yl) phenyl] -1-benzothiophene-2-formamide.

How competitive 3-chloro-6-fluoro-N- [4- (morpholin-4-yl) phenyl] -1-benzothiophene-2-carboxamide in the market

There are 3 - chloro - 6 - fluoro - N - [4 - (morpholin - 4 - yl) phenyl] -1 - benzothiophene - 2 - carboxamide, which is competitive in the market. I will analyze it in detail.

Guanfu This compound has a unique structure and is cleverly spliced from benzothiophene, chlorine, fluorine, morpholinyl phenyl and carboxamide. This unique structure may endow it with specific physical and chemical properties and biological activities.

In the field of pharmaceutical research and development, it may have potential medicinal value. If it can demonstrate good pharmacological activity, such as high selectivity, strong affinity for specific disease targets, and low toxic and side effects, it will be able to emerge in the market competition. However, competition in this field is fierce, and many pharmaceutical companies are making every effort to develop new drugs. To stand out, they need to excel in many aspects such as activity, safety, and pharmacy.

In the field of chemical materials, if it can have special effects in material modification, catalysis, etc., it can also gain a place. However, the chemical market is also changing, and factors such as cost, difficulty and stability of production processes need to be considered. If the production process is complex, the cost is high, and even if it has excellent performance, it is difficult to compete with low-cost products.

Looking at marketing activities and marketing strategies, if enterprises can make good use of resources, accurately locate target customer groups, and efficiently disseminate product advantages, they will be able to increase their competitiveness. However, peer competition will also use every means, or reduce prices to achieve sales, or introduce new products to seize the market.

In summary, 3 - chloro - 6 - fluoro - N - [4 - (morpholin - 4 - yl) phenyl] -1 - benzothiophene - 2 - carboxamide has potential advantages in the market competition due to its unique structure, but it also faces various challenges. The strength of its competitiveness depends on its comprehensive performance in performance, cost, marketing activities and other aspects.