3-(Bromomethyl)-5-chloro benzo[b]thiophene

3- (bromomethyl) -5 -chlorobenzo [b] thiophene is a key intermediate in the field of organic synthesis. It has a wide range of uses, and is the first to be used in drug synthesis. Due to the unique structure of this compound, many active groups can be introduced through a specific reaction path, so as to construct a molecular structure with specific pharmacological activity. In the development of anti-cancer drugs, it is often used as a starting material to obtain new compounds with inhibition of tumor cell proliferation through chemical modification.
Furthermore, in the field of materials science, it also has extraordinary performance. Materials with special optoelectronic properties can be prepared by polymerization or compounding with other functional materials. If used in the synthesis of organic Light Emitting Diode (OLED) materials, the luminous efficiency and stability of the device can be improved, because it can adjust the molecular energy level structure of the material and optimize the charge transport performance.
In addition, in the field of pesticide synthesis, 3- (bromomethyl) -5 -chlorobenzo [b] thiophene also plays an important role. After chemical transformation, pesticide ingredients with high insecticidal and bactericidal activities can be synthesized. Because the specific structure can bind to specific targets in the body of pests or pathogens, it interferes with their physiological and metabolic processes, achieving the purpose of controlling pests and diseases.
In summary, 3 - (bromomethyl) -5 -chlorobenzo [b] thiophene is an indispensable intermediate in many fields such as drugs, materials and pesticides due to its unique structure and reactivity, and has made great contributions to promoting technological development and innovation in related fields.

The synthesis method of 3- (bromomethyl) -5 -chlorobenzo [b] thiophene is an important topic in the field of organic synthesis. To make this compound, the following methods are commonly used.
First, the compound containing thiophene structure is used as the starting material. First, the thiophene ring is modified with appropriate substituents to make the specific position have a suitable activity check point. Chlorine atoms can be introduced into the thiophene ring by halogenation reaction, and the reaction conditions, such as reaction temperature, time and amount of halogenated reagent, can be precisely controlled to achieve the purpose of introducing chlorine atoms at the desired position. Subsequently, bromomethyl is introduced by alkylation reaction. In this process, it is necessary to carefully select the appropriate bromomethylation reagent, and pay attention to the pH of the reaction system and the choice of solvent, because these factors will have a significant impact on the selectivity and yield of the reaction.
Second, there are also those who start directly with the parent body of benzo [b] thiophene. First, it is brominated to selectively connect the bromine atoms to a specific position. This step requires clever use of the knowledge of positioning effects, rational selection of catalysts and reaction environments, in order to achieve efficient bromination. Then, after a series of transformations, chlorine atoms and bromomethyl atoms are introduced at appropriate stages. During the whole process, the separation and purification of intermediates is crucial, which is related to the purity and yield of the final product.
Third, the strategy of constructing thiophene rings can also be considered for synthesis. That is, the skeleton containing thiophene rings is first constructed with appropriate raw materials, and chlorine atoms and bromomethyl are skillfully introduced to suitable positions during the construction process. Although this method may be more complicated, it can provide more flexibility and selectivity for synthesis, but it also requires more control of reaction conditions and processing of intermediates.
All synthesis methods have their own advantages and disadvantages. In practical applications, it is necessary to comprehensively weigh and carefully select the appropriate synthesis path according to many factors such as the availability of raw materials, the difficulty of reaction, cost, and the purity requirements of the target product. Only then can 3 - (bromomethyl) -5 - chlorobenzo [b] thiophene be obtained efficiently and with high quality.

3 - (bromomethyl) -5 -chlorobenzo [b] thiophene is one of the organic compounds. Looking at its physical properties, at room temperature, it is mostly in a solid state. Because of its strong intermolecular forces, the molecules are closely arranged, so it has a solid form.
When it comes to color, it is usually white or white-like powder. This is determined by the electron transition characteristics in its molecular structure, which absorbs visible light specifically, resulting in its appearance.
Its melting point is also an important physical property. Experiments have shown that the melting point is in a specific temperature range, and this temperature limit is determined by factors such as intermolecular interactions and lattice energy. When the temperature rises to the melting point, the molecule is energized enough to overcome the lattice binding and gradually melts from the solid state to the liquid state.
Furthermore, solubility is also a key property. In organic solvents such as dichloromethane and chloroform, its solubility is acceptable. Because the compound molecule has a certain hydrophobicity, it can interact with organic solvent molecules by van der Waals force, etc., making it soluble in such solvents. However, in water, the solubility is very small, because water molecules have strong polarity, and the force between the molecules and the compound is weak, making it difficult to disperse it in water.
In addition, the compound has a higher density than water. If mixed with water, it will sink to the bottom, which is also a characterization of its physical properties.
It can be seen from the above that the physical properties of 3 - (bromomethyl) -5 -chlorobenzo [b] thiophene, such as morphology, color, melting point, solubility and density, are determined by its molecular structure and composition, and are closely related to these physical properties in the fields of organic synthesis and materials science.

3- (bromomethyl) -5 -chlorobenzo [b] thiophene, this is an organic compound. It has many unique chemical properties, and the following is a detailed discussion.
The structure of this compound is first described. This compound is based on a benzothiophene ring, with bromomethyl added at the 3rd position and chlorine atoms introduced at the 5th position. This structure endows it with special electronic effects and steric resistance, which has a great impact on its chemical activity.
In terms of reactivity, bromine atoms in bromomethyl are extremely active and easily participate in nucleophilic substitution reactions. For example, when encountering nucleophiles such as alcohols and amines, bromine atoms will be replaced by nucleophilic groups, thereby forming new carbon-heteroatom bonds. This property provides convenience for the synthesis of complex organic molecules, which can be used to introduce multi-functional groups and expand the diversity of molecular structures.
The 5-position chlorine atom, although slightly less active than bromomethyl, can also participate in nucleophilic substitution or metal catalytic coupling reactions under specific conditions. For example, when a suitable metal catalyst and ligand exist, the chlorine atom can undergo Suzuki coupling reaction with arylboronic acid to achieve arylation modification and enrich the structure of the compound.
In terms of chemical stability, the benzothiophene ring exists due to the conjugation system, which has certain stability. However, the introduction of bromomethyl and chlorine atoms weakens the overall stability to a certain extent, especially bromomethyl, which is vulnerable to nucleophilic attack and reacts.
In terms of solubility, considering that the compound contains hydrophobic benzothiophene rings and halogenated hydrocarbon groups, it exhibits good solubility in common organic solvents such as dichloromethane, chloroform, tetrahydrofuran, etc., which is quite favorable for its participation in organic synthesis reactions and facilitates efficient reaction in homogeneous systems.
In short, 3 - (bromomethyl) -5 -chlorobenzo [b] thiophene has broad application prospects in the field of organic synthesis due to its special structure, active reaction activity, specific stability and solubility.

Now I want to know the price of 3- (bromomethyl) -5 -chlorobenzo [b] thiophene in the market, but I have searched all over the ancient books, but I have not been able to obtain a definite price. This compound, either because of its specific use, has a small number of circulation in the market, or its preparation is difficult, so the price is difficult to determine.
In the past, "Tiangong Kaiwu" has a cloud, the price of things often varies with time, place, supply and demand. Today, 3- (bromomethyl) -5 -chlorobenzo [b] thiophene, if it is produced in the vicinity, its price is cheap; if it needs to be transported, the price will increase. And if there are many people who use it, the demand is greater than the supply, and the price is high; if few people are interested, the supply is oversupplied, and the price is low.
Looking at the properties of this compound, the preparation may require special methods and precious materials, and the cost is high, but the price is also difficult to reduce. However, because I have not obtained the actual transaction price on the market, it is difficult to determine its exact value. Or when consulting the business of chemical materials, or interviewing the shop specializing in such reagents, the exact price can be obtained.