3-(Bromomethyl)-5-chloro-1-benzothiophene

3- (bromomethyl) -5-chloro-1-benzothiophene, an organic compound, has a wide range of applications and has important uses in the fields of medicine, pesticides and materials.
In the field of medicine, it may serve as a key intermediate for the synthesis of compounds with specific biological activities. For example, in the development of some innovative drugs targeting specific disease targets, the unique chemical structure of 3- (bromomethyl) -5-chloro-1-benzothiophene can impart ideal pharmacological properties to drug molecules, such as better receptor affinity and higher bioavailability, thus enabling the creation of new therapeutic drugs.
In the field of pesticides, using this as a starting material can be used to construct pesticide products with high insecticidal, bactericidal or herbicidal activities through a series of chemical reactions. Its structural properties enable it to precisely act on specific physiological processes of pests to achieve the purpose of efficient prevention and control, while reducing the impact on the environment and non-target organisms.
In the field of materials science, 3- (bromomethyl) -5-chloro-1-benzothiophene also shows unique value. It may participate in the synthesis of polymer materials, endowing materials with novel electrical, optical or thermal properties. For example, in organic optoelectronic materials, the introduction of this compound structure can optimize the charge transport performance of the material and improve the luminous efficiency, and then be applied to the preparation of organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices.
In conclusion, the unique chemical structure of 3- (bromomethyl) -5-chloro-1-benzothiophene plays a key role in many fields, providing an important material foundation and innovation opportunity for the development of related industries.

There are several common methods for the synthesis of 3- (bromomethyl) -5-chloro-1-benzothiophene.
First, 5-chloro-1-benzothiophene is used as the starting material. First, 5-chloro-1-benzothiophene and N-bromosuccinimide (NBS) undergo a free radical substitution reaction in the presence of an initiator. Generally, benzoyl peroxide (BPO) is used as the initiator, and the reaction is heated in a suitable solvent such as carbon tetrachloride. In this process, NBS provides bromine free radicals to attack the methyl of 5-chloro-1-benzothiophene to generate 3- (bromomethyl) -5-chloro-1-benzothiophene. After the reaction is completed, the product can be purified by conventional post-processing operations such as reduced pressure distillation, column chromatographic separation, etc.
Second, 5-chloro-1-benzothiophene-3-methanol can be used as raw material. 5-chloro-1-benzothiophene-3-methanol is reacted with hydrobromic acid under appropriate conditions. The bromine ion in hydrobromic acid can undergo a nucleophilic substitution reaction with the alcohol hydroxyl group, and the hydroxyl group is replaced with a bromine atom to obtain the target product 3- (bromomethyl) -5-chloro-1-benzothiophene. The reaction is usually carried out under heating conditions to promote the reaction rate. After the reaction is completed, the separation and purification operation is also required. The difference in solubility between the product and the impurities in different solvents can be taken advantage of to obtain a pure product by extraction, recrystallization, etc.
Or, with a suitable benzothiophene derivative as the raw material, it is first halogenated at a specific position to introduce chlorine atoms, and then bromomethyl is introduced through a series of reactions. This process requires fine control of the reaction conditions, and the product must be properly handled after each step of the reaction to ensure that the reaction proceeds in the direction of generating 3- (bromomethyl) -5-chloro-1-benzothiophene, and to avoid unnecessary side reactions. Finally, the target product is obtained through multi-step reaction and separation and purification.

3 - (bromomethyl) -5 -chloro-1 -benzothiophene, this is an organic compound. Looking at its physical properties, it is often in a solid state at room temperature and pressure, due to intermolecular forces. Its melting point is also an important physical property, but I don't know the exact value. However, the melting point of organohalogenated aromatic compounds varies mostly due to the regularity of molecular structure and intermolecular forces.
On solubility, due to the aromatic structure of halogen atoms and benzothiophene, it is quite hydrophobic. In water, its solubility is extremely low, making it difficult to form effective interactions with water molecules. However, organic solvents, such as dichloromethane, chloroform, and toluene, have relatively high solubility due to the principle of similar miscibility. This property is very critical in organic synthesis, and it is often used to select suitable solvents to promote the reaction.
In addition to its appearance, it may be a white to light yellow crystalline powder, which is a common color state of many halogen-containing aromatic compounds, which is related to the absorption and scattering properties of light by the molecular structure.
Although its density is also one of the physical properties, I am not sure. However, it is speculated that it contains bromine and chlorine heavy atoms, and its density may be higher than that of common organic solvents. In summary, the physical properties of 3 - (bromomethyl) - 5 - chloro - 1 - benzothiophene are of great significance in the fields of organic synthesis, separation and purification.

3- (bromomethyl) -5 -chloro-1 -benzothiophene, this is an organic compound with unique chemical properties.
Its chemical activity is quite high, bromomethyl is active, and it is easy to involve nucleophilic substitution. In case of nucleophilic reagents containing hydroxyl groups and amino groups, bromine ions are easily replaced, and various new compounds are derived. For example, when reacted with alcohols, ether products can be formed; when reacted with amines, amine substitutes can be obtained, which is of great significance for the preparation of functional materials and pharmaceutical intermediates in organic synthesis.
5 -chlorine atoms also affect molecular properties and reactivity. The chlorine atom has an electron-absorbing effect, which changes the electron cloud density of the benzene ring, making the electrophilic substitution activity of the benzene ring different from that without chlorine substitution. Generally speaking, the electron cloud density of the benzene ring is reduced, and the electrophilic substitution reaction is more inclined to the mesotope.
1-benzothiophene structure endows the molecule with a certain conjugated system, resulting in specific optical and electrical properties. The conjugated structure often makes the compound a certain color or has fluorescence properties, which may have potential applications in the field of optoelectronic materials, such as organic Light Emitting Diodes, fluorescent probes, etc. Due to the presence of bromomethyl, chlorine atoms, and benzothiophene structures, this compound has active and unique chemical properties. It has shown broad application prospects in many fields such as organic synthesis, materials science, and drug development. Scientists can use its characteristics to design and synthesize more novel compounds with specific functions.

The market price of 3- (bromomethyl) -5 -chloro-1 -benzothiophene is difficult to determine. This compound is a raw material in the field of fine chemicals, and its price often varies for a variety of reasons.
First, the size of the output is related to the price. If the production of this substance is abundant and the supply exceeds the demand, its price may be easy; conversely, if the production is scarce and the supply exceeds the demand, the price may be high.
Second, the difficulty of preparation is also the key. If the synthesis of this compound is complicated, high-priced reagents and harsh conditions are required, resulting in high production costs and high prices.
Third, market demand also affects the price. If the demand for this product in a certain industry increases sharply, such as in the fields of medicine, electronic materials, etc., the price may rise; if the demand is low, the price may decline.
Fourth, fluctuations in the price of raw materials will also affect their price. If the price of raw materials for preparing this compound increases, the cost will increase, and the price will also increase accordingly.
According to past market trends, the price range of similar fine chemicals fluctuates greatly. Simple and easy to make and high-yield products may cost only a few yuan per gram; while those with difficult synthesis and special needs can reach hundreds of yuan per gram, or even more. However, the specific price of 3- (bromomethyl) -5-chloro-1-benzothiophene is difficult to determine. To know the exact price, you need to consult chemical raw material suppliers, traders, or check real-time quotations on the chemical product trading platform.