3-BROMO-4-FORMYLTHIOPHENE

3-Bromo-4-formylthiophene is a crucial organic compound in the field of organic synthesis. It is widely used in the field of medicinal chemistry and is often a key intermediate for the preparation of various biologically active drug molecules. Due to its unique chemical structure, it can interact with specific targets in organisms. After chemical modification and derivatization, new drugs with excellent efficacy can be created.
In the field of materials science, 3-bromo-4-formylthiophene also has important applications. It can be used as a building unit to participate in the synthesis of conjugated polymers. These polymers have unique photoelectric properties and play an indispensable role in the manufacture of optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells. It can improve the luminous efficiency and energy conversion efficiency of the device.
In addition, in the fine chemical industry, it can be used to synthesize special dyes, fragrances and functional additives. Due to the presence of bromine atoms and formyl groups in its structure, it endows the compound with rich chemical reactivity and can be converted into various fine chemicals with specific functions through various chemical reaction paths to meet the special needs of different industries. In summary, 3-bromo-4-formylthiophene has shown significant application value in many fields, which is of great significance for promoting the development of related industries.

There are several methods for the synthesis of 3-bromo-4-formylthiophene. One method is also to use thiophene as the starting material and obtain it through a multi-step reaction. The thiophene is first brominated under appropriate conditions and bromine atoms are introduced. The bromination method, or the reaction of liquid bromine with a suitable catalyst at low temperature or room temperature, can obtain bromine-containing thiophene derivatives. Among them, attention should be paid to the control of the reaction conditions. If the temperature is too high, by-products such as polybrominates may be generated, which affects the yield and purity.
Then, the obtained bromine-containing thiophene derivatives are formylated. The method of formylation can be used, such as the Vilsmeier-Haack reagent composed of phosphorus oxychloride and dimethylformamide (DMF). In this reaction, the reagent interacts with the bromine-containing thiophene derivative, and the formyl group is introduced at the appropriate position of the thiophene ring to obtain 3-bromo-4-formylthiophene. In this step, the reaction time, temperature and the dosage ratio of the reagent all have a great influence on the formation of the product and must be carefully regulated.
Another way, or the thiophene can be formylated first and then brominated. After formylation, the electron cloud density distribution of the thiophene ring changes, and the substitution position of the bromine atom during bromination is different. This strategy can guide bromine atoms to be substituted at specific positions by selecting suitable bromination reagents and conditions to achieve the purpose of synthesizing the target product. However, no matter what method, the reaction of each step needs to be carefully optimized, taking into account the reaction conditions, raw material ratio, post-processing steps and many other factors, in order to obtain a higher yield and purity of 3-bromo-4-formylthiophene.

3-Bromo-4-formylthiophene is a kind of organic compound. Its physical properties are particularly important, related to its application and characteristics.
First of all, its appearance, under normal conditions, is mostly solid state, which is caused by its intermolecular forces. Color or light yellow, but also varies depending on the purity and preparation method. This compound has a certain melting point, about [specific melting point value]. If heated to this temperature, it will gradually melt from solid to liquid. The determination of the melting point can help to determine its purity. The melting point of pure products is relatively fixed, and the mixing of impurities will cause the melting point to decrease and the melting range to widen.
Furthermore, its solubility also has characteristics. In organic solvents such as dichloromethane, chloroform, and tetrahydrofuran, it has good solubility. Due to the similar miscibility, such organic solvents have a fit with the molecular structure of 3-bromo-4-formylthiophene, and forces can be formed between molecules, so they can dissolve each other. However, in water, the solubility is not good, and the hydrogen bond between water molecules is difficult to interact with the compound, so it is difficult to dissolve.
In addition, the density of this compound is also a characteristic. Its density is about [specific density value], which is slightly heavier than that of water. This property needs to be paid attention to in separation, extraction, etc., and a reasonable separation process can be designed according to the relationship between its density and the density of the liquid involved. < Br >
And its volatility is low. Due to the existence of van der Waals forces and other forces between molecules, it is difficult for molecules to escape from the liquid phase and enter the gas phase. This property makes the compound relatively stable at room temperature and pressure, and it is not easy to evaporate and dissipate quickly.
All these physical properties are necessary to consider when studying and applying 3-bromo-4-formylthiophene. They are of great guiding significance in the experimental links of synthesis, separation, characterization, and practical industrial applications.

3-Bromo-4-formylthiophene is one of the organic compounds with unique chemical properties. It contains bromine atoms and formyl groups, which give the compound active chemical activity.
Let's talk about bromine atoms first. Bromine is a halogen element with strong electronegativity. In 3-bromo-4-formylthiophene, bromine atoms change the distribution of molecular electron clouds, reducing the density of adjacent and para-electron clouds, making it more prone to nucleophilic substitution reactions. Like meeting nucleophilic reagents, such as alcohols and amines, bromine atoms can be replaced to form new organic compounds.
Re-discussion on formyl, formyl (-CHO) is unsaturated and polar. Its carbon-oxygen double bond electron cloud is biased towards the oxygen atom, making the carbon atom partially positively charged and vulnerable to attack by nucleophiles. Common reactions such as acetalylation with alcohols produce acetals; in the case of reducing agents, such as sodium borohydride and lithium aluminum hydride, it can be reduced to alcohol hydroxyl groups.
In addition, the thiophene ring itself also affects the chemical properties of the compound. Thiophene is aromatic, and the electron cloud is distributed over the entire ring, making the molecule relatively stable. However, compared with benzene, the electron cloud density of thiophene ring is uneven and the reactivity is different.
3-Bromo-4-formylthiophene exhibits rich chemical reactivity due to the interaction of bromine atom, formyl group and thiophene ring, and has a wide range of uses in the field of organic synthesis. It can be used as an intermediate to prepare various functional materials and bioactive molecules.

What you are asking about is the price range of 3-bromo-4-formylthiophene in the market. However, the price of the market often changes due to multiple reasons, and it is difficult to give a definite number.
This compound is quite useful in the fields of chemical industry, pharmaceutical research and development. The change in its price is primarily due to supply and demand. If there are many people who want it, and there are few people who supply it, the price will increase; on the contrary, if the supply exceeds the demand, the price will drop.
Second, the price of raw materials is also a major factor. If the price of the raw material required for the synthesis of 3-bromo-4-formylthiophene increases, the price of the compound will also increase; if the price of the raw material decreases, the price may decrease.
Furthermore, the difficulty of production and the level of technology also affect. If the synthesis method is complicated, high technology and multiple costs are required, the price will be high; if there is a simple and efficient method, the cost will decrease and the price will also decrease.
Also, the situation of market competition should not be ignored. If the competition in the same industry is intense, merchants may reduce prices to occupy the market; if there is little competition, the price may be stable and high.
In my opinion, if you want to know the exact price range, you should consult the quotation of chemical raw material suppliers, reagent sellers, or the chemical product trading platform to obtain a more accurate number.