3-BORONO-2-THIOPHENECARBOXYLIC ACID

3-Boron-2-thiophene carboxylic acid, its chemical structure is as follows: The thiophene ring is the core skeleton of the compound. The thiophene ring is a five-membered heterocyclic ring composed of four carbon atoms and one sulfur atom, which has aromatic properties. At position 2 of the thiophene ring, a carboxyl group (-COOH) is connected. This carboxyl group is composed of a carbonyl group (C = O) and a hydroxyl group (-OH), which gives the compound a certain acidity. At position 3 of the thiophene ring, a boron group (-B (OH) -2) is connected, and the boron atom is connected to two hydroxyl groups. In this way, the parts are connected in an orderly manner through chemical bonds to form a unique chemical structure of 3-boron-2-thiophene carboxylic acid, which endows the compound with specific physicochemical properties and potential chemical reactivity. It has important applications in many fields such as organic synthesis and medicinal chemistry.

3-Boron-2-thiophene carboxylic acid is widely used. In the field of organic synthesis, it is often a key raw material. Due to the unique chemical properties of boron groups with thiophene rings and carboxyl groups, it can be coupled with many halogenated hydrocarbons through various chemical reactions, such as Suzuki-Miyaura coupling reaction, to construct complex organic molecular structures. When creating new drugs and developing functional materials, it can be used to build a key skeleton, which is of great significance in pharmaceutical chemistry and materials science. < Br >
In the field of materials science, the materials prepared through this compound endow the materials with unique photoelectric properties due to the conjugation properties of thiophene rings and the activities of boron and carboxyl groups. If applied to organic Light Emitting Diode (OLED) materials, it may improve the luminous efficiency and stability of the material; when used in solar cell materials, it may improve the absorption of light and charge transport ability, thereby enhancing the conversion efficiency of the battery.
In the field of medicinal chemistry, the structure of the compound may have potential biological activity. Using it as a starting material, modified and modified, or drug molecules with affinity for specific targets can be obtained. The combination of thiophene ring with boron and carboxyl groups can interact with specific parts of biological macromolecules, such as binding with the activity check point of proteins, or affecting the catalytic activity of enzymes, providing the possibility for the development of new therapeutic drugs.

The synthesis of 3-boron-2-thiophene carboxylic acid is related to the technology of organic synthesis. The method has various paths, which are described in detail below.
First, it can be started by a compound containing thiophene structure, and a halogen atom, such as a bromine atom, can be introduced into a specific position of thiophene by halogenation reaction. This step requires appropriate reaction conditions, and the choice and dosage of halogenating agent, reaction temperature and time are all critical. Usually, liquid bromine or N-bromosuccinimide (NBS) are used as halogenating agents, and the corresponding halogenated thiophene derivatives can be obtained by reacting in a suitable solvent such as carbon tetrachloride in the presence of light or initiator.
Then, the halogenated thiophene derivative is reacted with a metal reagent, such as to make a Grignard reagent or a lithium reagent. Taking Grignard reagent as an example, in an anhydrous ether or tetrahydrofuran solvent, the halogenated thiophene reacts with magnesium chips to form a thiophenyl Grignard reagent. This reaction requires a strict anhydrous and anaerobic environment to prevent the Grignard reagent from decomposing in contact with water or oxygen. After
, the generated Grignard reagent reacts with borate esters. The borate ester can be selected from trimethyl borate or triethyl borate, etc., and the two are mixed at low temperature for a period of time. This step aims to introduce boron groups on the thiophene ring by means of a nucleophilic substitution reaction < Br >
After the reaction is completed, the reaction mixture is treated with a dilute acid solution through a hydrolysis step, so that the borate ester is hydrolyzed into boric acid, and 3-boron-2-thiophene carboxylic acid is obtained. The subsequent process needs to be separated and purified. The commonly used method is column chromatography or recrystallization to improve the purity of the product.
Another way is to start from thiophene derivatives with carboxyl groups and directly introduce boron groups through a specific boration reaction. This requires the use of suitable boronation reagents, such as bis (pinacol) diboron (B -2 pin -2), and a transition metal catalyst, such as palladium catalyst. In the presence of a base, the reaction is heated in a suitable solvent to achieve the substitution of boron groups for specific positions on the thiophene ring, and finally the target product 3-boron-2-thiophene carboxylic acid can be obtained, and the subsequent separation and purification steps are also required to refine the product.

3-Boron-2-thiophene carboxylic acid, the physical properties of this substance are related to its many properties. Its appearance is often in a solid state, and it may have a specific crystal structure in the solid state, which affects its stability and many physical behaviors.
In terms of solubility, the solubility in water depends on the interaction between molecules and water molecules. This molecule has a certain solubility due to the presence of polar groups such as carboxyl and boron groups, or in polar solvents such as water, but the exact solubility is also affected by factors such as temperature. Raising the temperature may increase its solubility in water. < Br >
Melting point is one of the characteristics of the substance. The melting point of 3-boron-2-thiophene carboxylic acid reflects the strength of the intermolecular force. If the intermolecular force is strong, higher energy is required to overcome it, and the melting point is also high. This melting point data can help identify the substance, which is of great significance in the process of purification and analysis.
The density reflects the mass of the substance per unit volume, which is affected by the way of molecular accumulation and atomic composition. Its density value provides basic data for studying the behavior of the substance in different environments, such as distribution in solution and interaction with other substances.
In addition, its refractive index is also an important physical property. The refractive index reflects the change of the speed and direction of light propagation in the substance, and is related to the molecular structure and electron cloud distribution. By measuring the refractive index, information about the molecular microstructure can be obtained, providing a unique perspective for the identification and analysis of the substance.
The above physical properties are related to each other and together describe the physical properties of 3-boron-2-thiophene carboxylic acid, which lays a theoretical foundation for its application in chemical synthesis, materials science and other fields.

I look at the "3 - BORONO - 2 - THIOPHENECARBOXYLIC ACID" you are inquiring about, this is a chemical substance, the Chinese name is or "3 - boron - 2 - thiophene carboxylic acid". As for its market price, it is difficult to determine. Because the market price is easy, it often changes with many factors.
First, the situation of supply and demand is the main reason. If there are many applicants for this product, but there are few producers, the price will rise; conversely, if the supply exceeds the demand, the price may drop. Second, the difficulty of preparation also affects its price. If the synthesis method is difficult, the materials used are expensive, the cost is high, and the price will be high; if the preparation is simple, the cost will drop and the price will also be lower. Third, the difference in quality is related to the price. Those with high purity have a wide range of uses and excellent efficiency, and the price should be higher than those with low purity. Fourth, competition in the market also has an impact. Businesses compete for profits, or reduce prices to attract customers; if there are few merchants, it is easy to become a monopoly, and the price may be high.
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