3-AMINO-5-METHYLTHIOPHENE-2-CARBOXYLIC ACID,MET. ESTER

3-Amino-5-methylthiophene-2-carboxylic acid methyl ester, this substance is widely used. In the field of medicinal chemistry, it is often used as a key intermediate to synthesize many drugs with specific biological activities. Due to its unique chemical structure, it can participate in a variety of chemical reactions to build complex drug molecular structures, providing basic materials for drug research and development, and helping to create new specific drugs to deal with various diseases.
In the field of materials science, it also has important value. In some cases, it can be treated by special processes to make it participate in material synthesis, endowing the material with unique properties, such as improving material stability, conductivity or optical properties, etc., and applied to electronic devices, optical materials and other fields to promote the progress of materials science.
In the field of organic synthesis chemistry, it is an extremely important starting material and reaction reagent. Chemists can expand the molecular diversity of organic compounds by performing various functional group transformation, condensation, cyclization and other reactions, and prepare a series of organic compounds with novel structures. This is of great significance to the development of organic synthesis methodologies and provides the possibility for the synthesis of more complex and valuable organic molecules.
The application of this compound in many fields has strongly promoted the development of related disciplines and technological innovation, and has made significant contributions to human life and scientific and technological progress.

3-Amino-5-methylthiophene-2-carboxylic acid methyl ester, this material has many physical properties. Its appearance is often white to light yellow crystalline powder, fine texture, and its fine crystal structure can be seen in light.
When talking about the melting point, it is about 145-149 ° C. When the temperature gradually rises to the melting point, the substance gradually melts from solid to liquid state. This process requires absorption of a certain amount of heat to break the intermolecular force.
Its solubility also has characteristics, slightly soluble in water. Although it contains polar groups in its molecular structure, the overall hydrophobic part accounts for a large proportion, so it is difficult to dissolve in water with strong polarity. However, in common organic solvents, such as ethanol and dichloromethane, it has a certain solubility. In ethanol, with the increase of temperature, the solubility increases gradually. Due to the increase of temperature, the thermal movement of molecules intensifies, and the interaction between solvent and solute molecules enhances.
In terms of density, it is about 1.38 g/cm ³, which is similar to that of common organic compounds, indicating that the molecular packing density is moderate.
In addition, the chemical properties of this substance are relatively stable at room temperature and pressure. In case of extreme conditions such as strong acid, strong base or high temperature, the molecular structure may change, triggering chemical reactions and affecting its physical properties.

The preparation of 3-amino-5-methylthiophene-2-carboxylic acid methyl ester can be done according to the following ancient method.
Take 5-methylthiophene-2-carboxylic acid methyl ester as the starting material, which is the key substrate. In an appropriate reactor, put a certain amount of 5-methylthiophene-2-carboxylic acid methyl ester, and then add an appropriate amount of nitrifying reagent, such as concentrated nitric acid and concentrated sulfuric acid mixed acid. This mixed acid ratio needs to be precisely controlled. Usually, the volume ratio of concentrated sulfuric acid to concentrated nitric acid is about 3:1. The reaction temperature should be maintained at a low temperature, such as 0-5 ° C, to prevent excessive nitrification. Slowly add the mixed acid dropwise, with continuous stirring, so that the reaction proceeds uniformly. After several times of reaction, 5-methyl-3-nitrothiophene-2-carboxylic acid methyl ester can be obtained.
Then remove the nitro product and transfer it to another reaction vessel. Add an appropriate amount of reducing agent, such as a combination of iron powder and hydrochloric acid. The amount of iron powder should be excessive to ensure the complete reduction reaction. The concentration of hydrochloric acid is about 6mol/L, and the reaction temperature is controlled at 60-70 ° C. When the reaction number is stirred at this temperature, the nitro group is then reduced to an amino group to obtain the target product 3-amino-5-methylthiophene-2-carboxylic acid methyl ester.
After the reaction is completed, the reaction mixture is post-processed. The organic phase is first extracted with an appropriate amount of organic solvent, such as ethyl acetate, and the organic phase is separated. The organic phase is dried with anhydrous sodium sulfate to remove moisture. After distillation under reduced pressure, the organic solvent is removed to obtain the crude product. Finally, the product can be further purified by recrystallization method, such as ethanol-water mixed solvent, to obtain pure 3-amino-5-methylthiophene-2-carboxylic acid methyl ester.

I look at your question, but I am inquiring about the price range of methyl 3-amino-5-methylthiophene-2-carboxylate in the market. However, the price of this chemical often changes due to a variety of reasons, and it is difficult to determine the exact number.
In the past, the price of chemicals in the city was related to the state of supply and demand, the quality of the product, the amount of purchase, the distance of origin, and changes in market conditions. If the demand for this product is strong and the supply is low, the price will necessarily increase; on the contrary, if the supply exceeds the demand, the price may fall.
Furthermore, those with excellent quality will always be higher than the price of ordinary products. If the purchase quantity is huge, the price will also be different if the business or discount is given. The distance of the place of origin is related to the cost of transportation, and it also affects the price. And the market situation fluctuates from time to time, and prices also fluctuate.
Therefore, if you want to know the exact price range, you can go to the platform of chemical trading, such as Gade Chemical Network, to check the listed price; or consult the supplier of chemical raw materials and ask for the latest quotation. In this way, you can get a closer price range.

3-Amino-5-methylthiophene-2-carboxylic acid methyl ester should be stored in a cool, dry and well-ventilated place. This is due to its chemical properties. High temperature, humidity or poor ventilation can easily cause its properties to vary and damage quality.
It should be kept away from fire and heat sources to prevent the risk of fire and explosion. The substance may be flammable, exposed to open flames, hot topics, or cause danger.
It should be stored separately from oxidants, acids, bases, etc., and cannot be mixed. Because these substances come into contact with it, or react chemically, cause it to deteriorate, and may produce harmful products, endangering safety.
Storage containers must be tightly sealed to prevent moisture, air and other impurities from invading. Good sealing can maintain its chemical stability and prolong the shelf life.
Storage areas should be equipped with suitable materials to deal with possible leaks. In this way, once a leak occurs, it can be dealt with in time to reduce harm.
Daily regular inspection of storage conditions to check whether the container is damaged, leaked, and whether there are abnormal changes in substances. If there is any abnormality, take measures quickly to ensure storage safety.