3-Amino-5-methyl-thiophene-2-carboxylic acid

3-Amino-5-methyl-thiophene-2-carboxylic acid, which has a wide range of uses. In the field of medicine, it is a key intermediate for the synthesis of many effective drugs. The unique structure of the Geiinthiophene ring and the amino and carboxyl groups endows the drug with unique biological activity, which can be used to develop antibacterial, anti-inflammatory, anti-tumor and other drugs. For example, after specific reaction modification, it can combine with specific targets of diseased cells to exert the effect of precision therapy.
In the field of materials science, it can participate in the synthesis of functional materials. With its own structural properties, it can change the electrical and optical properties of materials. When preparing organic semiconductor materials, the introduction of this compound can optimize the carrier transport performance of the material and enhance the application potential of the material in electronic devices such as organic Light Emitting Diodes and field effect transistors.
In agricultural chemistry, it can be used as a raw material for the synthesis of new pesticides. After chemical modification, pesticides with high insecticidal and bactericidal properties can be prepared, and because of its structural characteristics, or low toxicity and environmental protection advantages, it has little impact on the environment and is suitable for the current development of green agriculture.
In the field of organic synthesis, it is an extremely important basic raw material. It can build complex organic molecular structures through a variety of chemical reactions, such as esterification, amidation, etc., providing important support for the development of organic synthetic chemistry, assisting chemists in exploring more novel organic compounds, and expanding the boundaries of organic chemistry research.

The synthesis method of 3-amino-5-methyl-thiophene-2-carboxylic acid has been known since ancient times. There are many methods, which are described in this article.
First, it starts with a compound containing thiophene structure and is obtained by multi-step conversion. At the beginning, select a suitable thiophene derivative and add a specific reagent and catalyst to a suitable reactor. For example, take a thiophene ester compound as an example, first treat it with alkali solution to promote its hydrolysis and make the ester group into a carboxyl group. This step requires moderate temperature control, not too high or too low. If the temperature is too high, it is easy to cause side reactions, and if it is too low, the reaction is slow. After the hydrolysis is completed, it is neutralized in acid to obtain a thiophene compound containing carboxyl groups.
Then, amino and methyl groups are introduced. Appropriate amine reagents can be selected through nucleophilic substitution reaction, and the amino group can be connected to the designated position of the thiophene ring under the action of the catalyst. This process requires attention to the pH of the reaction environment. Improper pH will affect the reaction process and product purity. At the same time, halomethane is used as a methylation reagent, and methyl groups are introduced under alkali catalysis. During operation, it should be ensured that the proportion of reagents is accurate and stirred evenly to make the reaction sufficient.
Second, the strategy of constructing thiophene rings is also used. First, small molecules containing sulfur, carbon and other elements are used as raw materials, and the prototype of the thiophene ring is built through condensation reaction. For example, taking a thiolenone-containing and unsaturated nitrile compound as an example, under specific catalyst and reaction conditions, a cyclization reaction occurs to form a thiophene ring. Then, the groups on the ring are modified in sequence, and methyl groups are introduced first, and then amino and carboxyl groups are introduced through specific reactions. This path requires familiarity with the mechanism of each step of the reaction and precise control of the reaction conditions in order to obtain the target product.
Third, there is still an improved method. First prepare an intermediate containing part of the target group, and then introduce the remaining groups through clever reactions. For example, thiophene intermediates containing methyl and carboxyl groups are synthesized first, and then amino groups are introduced in one step through a unique amination reaction. This improved method can simplify the steps and improve the yield, but the requirements for reaction conditions and reagents are more stringent.
All this synthesis method requires careful operation by the experimenter, fine regulation of the reaction conditions, and attention to the details of the reaction at each step, so that the product can be obtained smoothly and the purity can reach the standard.

3-Amino-5-methyl-thiophene-2-carboxylic acid is a kind of organic compound. Its physical properties are unique, let me tell them one by one.
Looking at its properties, it is mostly a crystalline solid under normal conditions, which is caused by the regular arrangement of molecular interactions. The color of this compound is often white to off-white, and the pure color also highlights the relative simplicity and purity of its chemical structure.
When it comes to the melting point, after many experiments, the melting point is roughly within a specific range, but due to the differences in experimental conditions, there may be slight differences. This melting point characteristic is crucial for identifying and purifying the compound. Due to the mixing of different impurities, the melting point value can be significantly affected, so the melting point can be used to determine its purity.
In terms of solubility, this compound exhibits different behaviors in organic solvents. In polar organic solvents, such as ethanol and acetone, it has a certain solubility. This is due to the interaction between polar groups such as amino groups and carboxyl groups in the molecule and polar solvent molecules, such as hydrogen bonds, which can be dissolved. However, in non-polar solvents, such as n-hexane, benzene, etc., its solubility is very small, and the overall polarity of its molecules is relatively high, and the interaction with non-polar solvent molecules is weak.
As for the boiling point, although it is difficult to determine accurately, it can be speculated that the boiling point is in a higher range due to the existence of various forces between molecules, such as hydrogen bonds, van der Waals forces, etc. This boiling point characteristic needs to be considered in detail in separation operations such as distillation.
In summary, the physical properties of 3-amino-5-methyl-thiophene-2-carboxylic acids, such as their properties, melting point, solubility and boiling point, lay a solid foundation for their application in chemical synthesis, analysis and testing. Many chemical operations and studies need to be based on a precise grasp of their physical properties in order to proceed smoothly.

The price of 3-amino-5-methyl-thiophene-2-carboxylic acid in the market is difficult to determine. Guanfu's "Tiangong Kaiwu", which is detailed in the production of general products, has not been involved in this product. A chemical product that covers this is not available at that time.
To know its price today, it depends on many ends. First, consider the purity of this product. The higher the purity, the higher the price. If it is a high-purity product, it can be used in fine chemicals, pharmaceutical research and development, etc., and the price must be high. Second, it depends on the trend of supply and demand. If there are many people in the market, but there are few people in supply, the price will rise; conversely, if the supply exceeds the demand, the price will fall. Third, it is related to the difficulty of production. If the preparation method is difficult and the consumables are laborious, the cost will be high and the price will be high; if the preparation is easy, the cost will drop, and the price will also be lower.
In addition, different places have different prices. The prosperous capital is Dayi, where trade is concentrated, logistics is convenient, or because of competition, the price may be slightly lower; in remote places, the price may be slightly higher due to transportation and other costs. Furthermore, different manufacturers have different pricing. Well-known large factories focus on quality, but their price may be high; small factories produce, but the price may be different.
From this perspective, if you want to know the market price of 3-amino-5-methyl-thiophene-2-carboxylic acid, you must widely observe the market and study all the reasons in detail before you can get a more accurate price.

3-Amino-5-methyl-thiophene-2-carboxylic acid, this is an organic compound, which is widely used in medicine, pesticides, materials and other fields. Its Quality Standard covers multiple elements, which are related to its quality and application effectiveness.
The first is the appearance, usually should be white to light yellow crystalline powder, no visible impurities, if the color is abnormal or there are foreign substances, or there are impurities mixed in or production process problems.
Purity is the key, generally need to reach a very high purity, often by high performance liquid chromatography (HPLC) determination. High purity can ensure the stability and consistency of product performance. Excessive impurities may affect the reactivity, product quality and biological activity. If used in pharmaceutical synthesis, low purity may cause poor drug efficacy and increased toxic and side effects.
Melting point is also an important indicator. The compound has a specific melting point range. By measuring the melting point, its purity and authenticity can be preliminarily judged. If the melting point deviates from the standard range, there may be impurities interfering with the lattice structure.
Moisture content cannot be ignored. Excessive moisture may affect the stability of the compound, causing hydrolysis or causing other side reactions. It is often determined by Karl Fischer method, etc., and needs to be controlled within a certain limit.
In addition, the content of heavy metals needs to be strictly controlled, because it may be harmful to human health and the environment. Generally, atomic absorption spectroscopy and other methods are used to detect to ensure compliance with relevant standards, which is particularly important in the application fields of medicine and food.
The Quality Standards of this compound are set from multiple dimensions such as appearance, purity, melting point, moisture and heavy metal content to ensure its quality and performance, and meet the needs of different application scenarios.