3-Amino-4-bromo-thiophene-2-carboxylic acid methyl ester

3-Amino-4-bromo-thiophene-2-carboxylic acid methyl ester, this is an organic compound with multiple chemical properties.
It is basic and due to the presence of amino groups. The nitrogen atom in the amino group contains lone pairs of electrons, which can accept protons and can form ammonium salts in acidic media. In this way, the compound can react with acids, such as with hydrochloric acid, the amino group binds protons to produce corresponding salts.
Because it contains bromine atoms, it can participate in nucleophilic substitution reactions. Bromine atoms are good leaving groups and are easily replaced when nucleophilic reagents exist. In case of nucleophilic reagents such as hydroxyl negative ions, bromine atoms may be replaced by hydroxyl groups to obtain new compounds containing hydroxyl groups.
The ester groups in the molecule also have unique chemical properties. The ester groups can undergo hydrolysis reaction catalyzed by acids or bases. In acidic hydrolysis, 3-amino-4-bromo-thiophene-2-carboxylic acids and methanol are formed; in alkaline hydrolysis, the corresponding carboxylic salts and methanol are formed, and the hydrolysis is more complete under alkaline conditions.
In addition, the thiophene ring endows it with aromatic properties and can participate in typical reactions of aromatic compounds, such as electrophilic substitution reactions. The density distribution of electron clouds on the thiophene ring allows it to undergo electrophilic substitution at specific locations, but the reactivity and selectivity are affected by other substituents.
The chemical properties of this compound are determined by the functional groups such as amino group, bromine atom, ester group and thiophene ring, which make it widely used in the field of organic synthesis. It can be used as an intermediate to construct complex organic molecules through various reactions.

To prepare 3-amino-4-bromo-thiophene-2-carboxylic acid methyl ester, the following method can be followed.
The starting material is preferably a compound containing thiophene structure. Bromine atoms can be introduced at a specific position of the thiophene ring first, and brominating reagents, such as liquid bromine, can be used to react in the presence of a suitable catalyst. The catalyst can be iron powder or iron tribromide, both of which can effectively promote the electrophilic substitution reaction of bromine and thiophene ring, so that the bromine atom just reaches the fourth position of the target. During the reaction, it is appropriate to control the temperature and pay attention to the monitoring of the reaction process, which can be observed by thin layer chromatography (TLC).
Wait for the 4-bromothiophene derivative to be obtained, and then introduce the carboxyl group. This can be used as a strong oxidant, such as potassium permanganate or potassium dichromate, to oxidize the specific side chain on the thiophene ring to the carboxyl group under suitable solvent and reaction conditions. After the reaction is completed, it must be separated and purified to obtain a pure 4-bromo-thiophene-2-carboxylic acid.
Then the carboxylic acid is converted to methyl ester. The esterification reaction between the carboxylic acid and the methanol catalyzed by concentrated sulfuric acid can occur. Concentrated sulfuric acid is not only a catalyst, but also helps the reaction balance to move in the direction of ester formation. During the reaction, heating and refluxing and timely water removal can promote the complete After the reaction, methyl 4-bromo-thiophene-2-carboxylate is obtained by neutralization, extraction, distillation, etc.
In the final step, the amino group is introduced at position 3 of methyl 4-bromo-thiophene-2-carboxylate. This can be reacted with a suitable amination reagent, such as liquid ammonia or ammonia water, under specific conditions such as catalyst or high temperature and pressure. Or a modified amination reagent can be used to achieve the purpose by borrowing a nucleophilic substitution reaction. After the reaction, it is carefully separated and purified, such as column chromatography, to obtain high-purity methyl 3-amino-4-bromo-thiophene-2-carboxylate.
During each step of the reaction, the separation and purification of the product is crucial, which is related to the purity and yield of the final product. Each step must be carefully operated, and the temperature control, time control and appropriate reaction conditions must be selected according to the reaction characteristics to effectively obtain this target compound.

3-Amino-4-bromo-thiophene-2-carboxylic acid methyl ester is widely used. In the field of medicinal chemistry, it is often used as a key intermediate to create a variety of bioactive compounds. For example, when developing new antibacterial drugs, it can be ingeniously introduced into a specific molecular structure through a series of chemical reactions, giving the drug unique antibacterial properties.
In the field of materials science, or can participate in the construction of functional materials. After rational design and synthesis, with the help of its special chemical structure, the material exhibits unique properties such as optics and electricity, and then is applied to the preparation of organic Light Emitting Diodes, sensors and other materials.
Furthermore, in the field of organic synthetic chemistry, due to the existence of thiophene ring, amino group, bromine atom and ester group, it provides many reaction check points, and can be used as a starting material. Through nucleophilic substitution, coupling and other reactions, complex and diverse organic compounds can be synthesized, which helps the development of organic synthesis methodology and the exploration of new compounds.

Methyl 3-amino-4-bromo-thiophene-2-carboxylate is an organic compound. When storing, many aspects need to be paid attention to.
The first is the environmental conditions. It should be stored in a cool, dry and well-ventilated place. This compound is quite sensitive to temperature fluctuations, and high temperature can easily cause it to decompose or deteriorate, so the temperature should be maintained in a low and stable state, usually 15-25 ° C. Air humidity should not be underestimated. If the humidity is too high, it is easy to cause deliquescence or cause adverse reactions with moisture, so the dry environment is the key.
Furthermore, it is necessary to pay attention to its isolation from other substances. Because of its specific chemical activity, it should avoid contact with strong oxidants, strong acids, strong bases and other substances. Strong oxidants may initiate oxidation reactions, while strong acids and strong bases may cause hydrolysis or other chemical reactions that damage the structure and purity of the compound. For example, it should not be co-located with concentrated sulfuric acid, sodium hydroxide, etc.
Packaging is also a key part. Be sure to choose suitable packaging materials, generally in containers with good sealing performance, such as glass bottles or specific plastic bottles, to ensure that there is no risk of leakage. This can prevent it from coming into contact with outside air, moisture, etc., to maintain its chemical stability.
In addition, the storage area should be kept away from fire and heat sources, because it may be flammable or when heated, the reactivity is enhanced, and it is stored near fire and heat sources, which is prone to safety accidents. And it needs to be clearly marked, indicating the name of the compound, properties, storage conditions and other key information, which is easy to access and manage, and can also allow operators to understand latent risks.
Daily management should not be ignored. It is necessary to regularly check the storage status to see if the package is damaged and the compound shows no signs of deterioration. If any abnormalities are found, they should be dealt with in time to prevent any impact on other stored items. Only in this way can 3-amino-4-bromo-thiophene-2-carboxylic acid methyl ester be properly stored to ensure its quality and safety.

I look at your question, but I am inquiring about the market price range of methyl 3-amino-4-bromo-thiophene-2-carboxylate. Sadly, although I imitate the style of "Tiangong Kaiwu", it is difficult to determine the price in the market. The price of this compound is unusual, and its price is affected by many factors.
First, the difficulty of preparation. If its synthesis requires complicated steps and rare raw materials, the price will be high. Second, the supply and demand situation of the market. If there are many people, and there are few suppliers, the price will also increase; on the contrary, if the supply is abundant and the demand is small, the price may drop. Third, the difference between manufacturers. Different manufacturers set different prices due to differences in technology and cost.
According to common sense, the price of fine chemicals varies greatly. Or a few yuan per gram, or hundreds of yuan per gram. This 3-amino-4-bromo-thiophene-2-carboxylic acid methyl ester, because of its special structure, if it is used in high-end pharmaceutical research and development or fine chemical industry, and is not easy to prepare, its price may be between tens of yuan and hundreds of yuan per gram. However, this is only speculation. If you want to know the exact price range, you can only find it by consulting chemical raw material suppliers, chemical reagent sellers, or detailed investigation on the chemical product trading platform.