3-(acetylamino)thiophene-2-carboxylic acid

3- (Acetamido) thiophene-2-carboxylic acid, this substance has a wide range of uses. In the field of pharmaceutical and chemical industry, it is often a key intermediate and can help synthesize various drugs. Taking antibacterial drugs as an example, by adding this substance through specific chemical reactions, it may improve the antibacterial activity and selectivity of the drug, precisely attack the bacteria, and reduce its damage to normal human cells.
In the field of materials science, or can participate in the creation of functional materials. Because of its unique molecular structure and chemical properties, or make the material have special optical and electrical properties. For example, when preparing photoelectric materials, adding an appropriate amount, or changing the photoelectric conversion efficiency of the material, it is widely used in photoelectric devices such as solar cells, Light Emitting Diode, etc.
In the field of organic synthesis, it is like a key that opens the door to the synthesis of a variety of complex organic compounds. Chemists can design exquisite reaction paths and build various novel organic frameworks according to their structural characteristics, injecting new vitality into the development of organic synthetic chemistry, promoting the field to continuously expand the boundaries, explore the world of unknown compounds, and generate more innovative achievements, serving human life and scientific and technological progress.

The synthesis method of 3- (acetamido) thiophene-2-carboxylic acid, although not detailed in the ancient book "Tiangong Kaiwu", can now be deduced according to the principles of chemistry.
One method can be started from thiophene-2-carboxylic acid. First react thiophene-2-carboxylic acid with an acetylating agent, such as acetic anhydride or acetyl chloride. Take acetic anhydride as an example, mix the two in a suitable solvent, such as pyridine, and heat them to a certain temperature for several hours. Pyridine can be used as a base to promote the reaction. The carboxyl group of thiophene-2-carboxylic acid has high activity and can undergo nucleophilic substitution with the acyl group of acetic anhydride, so 3- (acetamido) thiophene-2-carboxylic acid is obtained. The reaction formula is roughly as follows: thiophene-2-carboxylic acid + acetic anhydride → 3 - (acetamido) thiophene-2-carboxylic acid + acetic acid.
Another method can start from thiophene. First nitrify thiophene to give 2-nitrothiophene. The mixed acid of concentrated nitric acid and concentrated sulfuric acid is used as a nitrifying agent, and the temperature is controlled at low temperature to prevent side reactions. 2-Aminothiophene can be obtained by reduction of 2-nitrothiophene, such as iron powder and hydrochloric acid as reducing agents. 2-Aminothiophene is then reacted with acetylation reagents, such as the aforementioned acetic anhydride or acetyl chloride, under suitable conditions to obtain the target product. The reaction process is multi-step, and each step requires careful control of conditions. Temperature, time, and reagent dosage are all about success or failure.
In addition, there are also methods for synthesizing compounds containing thiophene structures using other thiophene structures as starting materials through multi-step conversion. Or first construct a thiophene ring, and then introduce acetamide and carboxyl groups; or introduce one first, and then try to add another group. In short, there are various methods of synthesis, but it is necessary to study the reaction conditions in detail according to the chemical principle in order to obtain it effectively.

3- (Acetamido) thiophene-2-carboxylic acid, this is an organic compound. Its physical properties are quite critical and it is widely used in chemical, pharmaceutical and other fields.
When it comes to appearance, under room temperature and pressure, it is mostly white to light yellow crystalline powder. This state is delicate, the texture is uniform, and the color is pure. Such appearance characteristics are easy to identify and handle in many reactions and applications.
Its melting point is also of great significance, about 190-194 ° C. The melting point is a key indicator to measure the purity and stability of the substance. In this temperature range, the substance gradually melts from a solid state to a liquid state, and this process is relatively stable, reflecting the characteristics of intermolecular forces. The accurate melting point indicates that the purity of the substance is high, which can ensure the accuracy and consistency of the reaction in synthesis and application.
In terms of solubility, 3- (acetamido) thiophene-2-carboxylic acid is slightly soluble in water. Water is a common solvent, and this property implies the difference between its molecular polarity and that of water molecules. Although slightly soluble, it is not completely insoluble. Under certain conditions, it can still form a certain equilibrium with water. In organic solvents, such as ethanol, dichloromethane, etc., its solubility is slightly better. Organic solvents have different polarities and structures, and can form different interactions with the substance, either van der Waals force or hydrogen bond, which affects their solubility. This solubility characteristic provides the basis for its separation, purification and reaction medium selection.
In addition, the density of the substance is about 1.47 g/cm ³. The density reflects the mass per unit volume of the substance, and this value indicates its mass distribution characteristics. During storage and transportation, density affects the choice of packaging and containers, and also affects the proportion and interaction with other substances when mixed.
In summary, the physical properties of 3- (acetamido) thiophene-2-carboxylic acids, from appearance, melting point, solubility to density, are all related and have their own uses. They play an indispensable role in research and application in related fields.

In today's world, it is not easy to know the market price of 3- (acetamido) thiophene-2-carboxylic acid. This compound is used in many fields such as chemical industry and medicine, and its price is also affected by many factors.
In the past, the price of the product often depended on the supply and demand of the market, the cost of production, and the quality. As for 3- (acetamido) thiophene-2-carboxylic acid, if the market demand is prosperous and the production is small, the price must rise; conversely, if the supply exceeds the demand, the price may drop.
The cost of production is also a major factor. The price of its raw materials, the process of making it, the cost of labor, etc., are all related to the final price. If the raw materials are rare and the craftsmanship is complicated, the cost will be high, and the price will follow.
Furthermore, its quality also affects the price. Those with high quality may have more advantages in specific fields, and the price may be higher than usual.
Today's market is changing rapidly, and the information is difficult to be detailed. Although you want to determine the price, it is difficult to have a fixed number. Or you can consult the merchants of chemical raw materials, the experts in the industry, or check the relevant market situation reports to get a rough price. However, it is only a temporary reference, and it is difficult to make constant accurate evidence.

3- (Acetamido) thiophene-2-carboxylic acid is an organic compound. When storing and transporting, pay attention to the following matters.
Bear the brunt, and the storage environment must be dry. If this compound is damp, or causes chemical reactions such as hydrolysis, it will deteriorate. Therefore, it should be stored in a dry place, away from water and moisture, and the environment can be maintained dry with the help of desiccants.
Second, temperature is also crucial. It should be stored in a cool place to avoid high temperature. Under high temperature, the compound may accelerate decomposition or undergo other chemical changes. Generally speaking, an environment at room temperature or slightly below room temperature is more suitable, and it should not be placed near direct sunlight or high-temperature equipment.
Furthermore, when transporting, it is necessary to ensure that the packaging is intact. This compound may be corrosive to a certain extent. If the packaging is damaged or leaks, it will corrode other objects, and even endanger the safety of transporters. Packaging materials should be selected that are resistant to chemical corrosion and tightly sealed.
In addition, this compound may react with other substances. When storing and transporting, it must not be co-stored with easily reactive substances. It needs to be stored and transported in isolation in strict accordance with the compatibility taboos of chemicals.
Because of 3- (acetamido) thiophene-2-carboxylic acid chemicals, storage and transportation must follow relevant regulations and standards. Operators should be professionally trained to understand their characteristics and safety precautions, so as to ensure the safety of storage and transportation and avoid accidents.