3-(ACETYLAMINO)-2-THIOPHENECARBOXYLIC ACID

3- (Acetamido) -2-thiophene carboxylic acid, this substance has a wide range of uses. In the field of medicine, it is often a key intermediate, helping to synthesize a variety of specific drugs. For example, in the preparation of some anti-inflammatory drugs, it can precisely react with other compounds by virtue of its unique chemical structure to build a complex molecular structure with anti-inflammatory activity, relieving the pain of inflammation for patients.
In the field of organic synthetic chemistry, it is an important raw material and participates in the careful creation of many organic compounds. Chemists skillfully use its characteristics to expand the diversity of organic molecules through a series of delicate reactions to meet different scientific research and industrial needs. For example, when synthesizing new organic materials with specific optical and electrical properties, 3- (acetamido) -2-thiophene carboxylic acid plays an indispensable role, contributing to the progress of materials science.
In the field of agriculture, it has also emerged. During the research and development of some pesticides, the compound can be rationally designed and modified to integrate into the pesticide molecular system to enhance the targeting and lethality of pesticides to specific pests and diseases, while reducing the adverse effects on the environment and non-target organisms, contributing to the sustainable development of agriculture, protecting the thriving growth of crops, and ensuring a bumper food harvest.

3- (acetamido) -2 -thiophenecarboxylic acid, this is an organic compound. Looking at its physical properties, it is in solid form at room temperature, which is determined by its intermolecular forces. Its color may be white to light yellow powder, and this color state characteristic is related to its molecular structure and electronic transition characteristics.
When talking about the melting point, it is about 190-195 ° C. The melting point range indicates the strength of the intermolecular forces. The melting point is relatively high. Due to the interaction of hydrogen bonds and van der Waals forces between molecules, high energy is required to destroy the lattice structure and cause it to melt.
Solubility, slightly soluble in water. In its molecular structure, although there are carboxylic groups that can form hydrogen bonds with water, the presence of acetamide and thiophene rings enhances the hydrophobicity of the molecule, so it is difficult to dissolve in polar solvent water. However, it is soluble in some organic solvents, such as dichloromethane, N, N-dimethylformamide, etc. In dichloromethane, it can be uniformly dispersed by the interaction between molecules and solvents; in N, N-dimethylformamide, due to the polarity of the solvent and the adaptation of some groups of the compound, it can also be well dissolved. This solubility characteristic has important application value in many fields such as organic synthesis, separation and purification.

There are several common methods for synthesizing 3- (acetamido) -2 -thiophene carboxylic acid.
First, thiophene is used as the starting material. First, the thiophene is acylated with an appropriate acylating agent, such as acetyl chloride or acetic anhydride, and under the catalysis of a suitable catalyst, such as Lewis acid such as anhydrous aluminum trichloride, the Fu-gram acylation reaction is carried out, and the acetyl group is introduced at the 2-position of thiophene to obtain 2-acetylthiophene. Subsequently, the 2-acetylthiophene is reacted with cyanizing agents such as sodium cyanide and substituted with cyanide to obtain 2 - (acetyl) -thiophene acetonitrile. Then the nitrile compound is hydrolyzed under the catalysis of acid or base, and it can be converted into 3- (acetamido) -2-thiophene carboxylic acid. In this process, the Fu-Ke acylation reaction needs to pay attention to the control of the reaction conditions, such as reaction temperature, catalyst dosage, etc., to ensure the selectivity of the acylation position; during the hydrolysis reaction, the reaction time and degree need to be controlled according to the selected acid and base conditions to avoid excessive hydrolysis or incomplete hydrolysis.
Second, use 2-aminothiophene as the starting material. Acetylation of 2-aminothiophene with acetic anhydride is carried out, and an acetyl group is introduced on the amino group to obtain 2- (acetaminothiophene) thiophene. Then, through a suitable carboxylation reaction, such as reaction with carbon dioxide under specific metal catalysts and basic conditions, the carboxyl group can be introduced into the 3-position of the thiophene ring to obtain the target product 3- (acetamino-) -2-thiophene carboxylic acid. In this route, the acetylation reaction is relatively direct, but the carboxylation reaction conditions are relatively harsh, and precise control of reaction parameters, such as temperature, pressure, catalyst type and dosage, is required to improve the yield and selectivity of the reaction.
Third, the functional group conversion strategy of thiophene derivatives can also be used. For example, thiophene derivatives with suitable substituents are selected, and the structure of the target molecule is gradually constructed through a series of gradual functional group conversion reactions, such as halogenation, substitution, oxidation, amidation, etc. Although this method may be cumbersome, the reaction route can be flexibly adjusted according to specific circumstances, which has certain advantages for some situations that require special reaction conditions or extremely high product purity. However, each step of the reaction requires fine operation and strict control of the reaction conditions to reduce the occurrence of side reactions, ensure the yield and product purity of each step, and finally achieve the effective synthesis of 3- (acetamido) -2-thiophenecarboxylic acid.

I look at your question, but I am inquiring about the price range of 3- (acetamido) -2-thiophene carboxylic acid in the market. However, the price of this product often changes for many reasons, and it cannot be generalized.
First, the source of the goods is different. If it comes from a reputable and high-quality factory, its price may be high; if it comes from a small factory, although the price may be cheap, the quality may also be poor.
Second, the amount of purchase is crucial. If the purchase volume is huge, the merchant may give a discount in order to promote the sale, and the price can be reduced; if the purchase volume is rare, the price may be high.
Third, the trend of supply and demand in the market is also an important factor. If the demand for this product is strong and the supply is limited, the price will rise; on the contrary, if the supply exceeds the demand, the price will decline.
Generally speaking, in the chemical reagent market, the price of small packages, such as several grams to tens of grams, may range from tens of yuan to hundreds of yuan per gram. If it is purchased in large quantities for industrial grade, the price per kilogram may be around hundreds of yuan in kilograms. However, this is only a rough estimate. The actual price needs to be consulted with chemical reagent suppliers, chemical raw material markets, etc., to obtain an accurate figure.

3 - (acetamido) -2 -thiophene carboxylic acid, this is an organic compound. Its storage conditions are quite important, related to its quality and stability.
This compound should be placed in a cool and dry place, away from strong direct light. UV rays and other rays in the sun may cause photochemical reactions, causing structural changes and damaging chemical properties. A cool place can slow down its molecular movement and reduce the rate of chemical reactions, which is of great benefit to maintaining chemical stability. If the temperature is too high, it may cause molecular activity to increase greatly, causing adverse reactions such as decomposition and polymerization.
Furthermore, keep the storage environment dry. Because it may have a certain degree of hygroscopicity, if the ambient humidity is high, it is easy to absorb water, or cause deliquescence, and the moisture may participate in chemical reactions, which affects the purity and quality.
When storing, it should be packed in a well-sealed container. This can prevent excessive contact with the air, due to the reaction of oxygen, carbon dioxide and other components in the air, or with compounds. Sealed containers can create a relatively independent and stable micro-environment and reduce external factors.
In addition, the storage area should be away from fire sources, heat sources and oxidants. This compound may be flammable, and there is a risk of combustion in case of fire sources and heat sources; and oxidants can react violently with many organic substances, causing danger.
In summary, 3 - (acetamido) -2 - thiophene carboxylic acid should be stored in a cool, dry, dark place, in a sealed container, and away from fire, heat and oxidants, so as to ensure its quality and stability, and play its due role in subsequent use.