3-(2-HYDROXYETHYL)THIOPHENE

3 - (2 - hydroxyethyl) pyridine, also known as 3 - （β - hydroxyethyl) pyridine, its main uses are as follows:
This substance has key uses in the field of chemical synthesis. In the pharmaceutical industry, it is often used as an important intermediate. Due to its unique chemical structure, it can participate in the construction process of a variety of drug molecules. For example, in the synthesis path of some cardiovascular drugs, 3 - (2 - hydroxyethyl) pyridine can be combined with other organic compounds through specific chemical reactions to gradually build a drug molecular skeleton with specific pharmacological activities. Through a series of substitution, addition and other reactions, the required functional groups can be precisely introduced, so as to prepare cardiovascular drugs with exact curative effect and help regulate the physiological functions of the human cardiovascular system.
In the field of materials science, it also shows important value. In the preparation of some functional polymer materials, 3- (2-hydroxyethyl) pyridine can participate in the polymerization reaction as a functional monomer. For example, when synthesizing polymers with special adsorption properties or ion conductivity properties, introducing them into the polymer main chain or side chain can endow the material with unique physical and chemical properties. These materials have potential applications in wastewater treatment, ion exchange membranes and other fields, which can achieve efficient adsorption and separation of specific substances or promote directional conduction of ions.
In addition, in the study of organic synthesis chemistry, 3- (2-hydroxyethyl) pyridine can be used as a versatile reagent to explore new chemical reaction paths and methods due to its structure of pyridine ring and hydroxyethyl group. Researchers use its reaction with different reagents under specific conditions to develop novel organic synthesis strategies, providing new ideas and methods for the development of organic chemistry, which helps to expand the synthesis range and structural diversity of organic compounds.

3 - (2 - cyanoethyl) pyridine is an organic compound, and its physical properties are as follows:
Looking at its properties, it usually shows a colorless to light yellow liquid state, which is convenient for mixing and interacting with other substances in many chemical reaction systems.
Smell its smell, with a special smell, this smell can be used as a simple preliminary identification feature, which helps to preliminarily determine whether the substance is 3 - (2 - cyanoethyl) pyridine in the experimental or production environment.
On its solubility, it is soluble in common organic solvents, such as ethanol, ether, etc. This property makes it widely used in the field of organic synthesis. It can be prepared into a solution of a specific concentration with the help of these organic solvents to participate in various reactions. In the process of separation and purification, it can be separated from other impurities by taking advantage of its solubility differences in different solvents.
Measure its boiling point and be in a certain temperature range. The exact boiling point data is of great significance for the separation and purification of substances. In distillation and other operations, setting the appropriate temperature according to its boiling point can accurately separate 3- (2-cyanoethyl) pyridine from the mixed system to ensure the purity of the product.
Measure its density and have a specific value. In practical applications, this physical quantity helps to accurately measure and proportion the substance. When preparing chemical reagents or conducting industrial production, it is accurately measured according to the density to ensure that the reaction is carried out according to the expected stoichiometric ratio, thereby improving product quality and production efficiency.

3 - (2 - hydroxyethyl) pyridine, also known as 2 - (3 - pyridyl) ethanol, has many chemical properties.
Its appearance is usually colorless to light yellow liquid, which is relatively stable at room temperature and pressure. In terms of solubility, it can be miscible with polar solvents such as water and ethanol, because its molecular structure contains hydroxyl groups and pyridine rings, which can form hydrogen bonds with water molecules, thereby improving solubility in polar solvents.
In terms of its chemical activity, hydroxyl groups have typical properties of alcohols and can undergo esterification reactions. For example, under the action of a catalyst with a carboxylic acid, a corresponding ester compound is formed. This reaction is achieved by dehydration and condensation between the hydroxyl group and the carboxyl group. At the same time, the pyridine ring also gives it unique properties. The pyridine ring has a certain alkalinity and can react with acids to form salts. For example, when reacting with hydrochloric acid, the nitrogen atom on the pyridine ring accepts protons to form pyridine hydrochloride. This basic property makes it a base catalyst in some organic synthesis reactions, promoting the reaction.
In addition, 3- (2-hydroxyethyl) pyridine can also participate in nucleophilic substitution reactions. Due to the presence of the pyridine ring, the electron cloud density of the carbon atom connected to the hydroxyl group decreases, making it more vulnerable to the attack of nucleophilic testers, and then substitution reactions occur, which are used in the field of organic synthesis to construct more complex molecular structures.

To prepare 3 - (2 - cyanoethyl) indole, there are many synthesis methods.
First, it can be started with o-nitrotoluene and acrylonitrile. First, the o-nitrotoluene is halogenated to obtain halogenated o-nitrotoluene, and then it is nucleophilic substituted with acrylonitrile under alkali catalysis to obtain 2 - (2 - nitrobenzyl) acrylonitrile. This intermediate is reduced, the nitro group is converted to an amino group, and then it is cyclized in the molecule and treated with an appropriate dehydrating agent to obtain 3 - (2 - cyanoethyl) indole. The reaction process, when halogenated, the halogen site selection is related to the electron cloud distribution of o-nitrotoluene; nucleophilic substitution, alkali activation of the carbon anion of acrylonitrile, attack the halogen site of halogenated o-nitrotoluene; reduction step, mostly metal and acid or catalytic hydrogenation method; cyclization dehydration, the reaction conditions need to be controlled to form a ring between amino and alkenyl groups and remove water molecules.
Second, indole and acrylonitrile are used as raw materials. In the presence of an appropriate catalyst, the 3-position hydrogen of indole has a certain activity and can react with acrylonitrile. This catalyst is often an alkali metal salt or an organic base. During the reaction, the catalyst activates the 3-carbon indole, and the carbon-carbon double bond of acrylonitrile is attacked, forming a carbon-carbon bond to obtain 3- (2-cyanoethyl) indole. This approach is relatively simple, but high-efficiency catalysts need to be found to increase the selectivity and yield of the reaction, and attention should be paid to side reactions, such as indole self-polymerization or acrylonitrile hydrolysis.
Third, o-amino acetophenone and ethyl cyanoacetate are used as starting materials. The two first condensate to form 2-cyano-3- (2-amino phenyl) ethyl acrylate, and then undergo a series of reactions such as reduction and cyclization, and finally obtain the target product. The condensation reaction is usually carried out under the catalysis of acid or base to form carbon-carbon bonds and carbon-nitrogen bonds; the subsequent reduction and cyclization steps require the selection of appropriate reagents and conditions to ensure the smooth progress of each step and improve the purity and yield of the product.

In "Tiangong Kaiwu", the price range of 3- (2-hydroxyethyl) indole in the market is related to many reasons. If this product is purchased in the market, the price involved first depends on the quality. Pure quality, the price must be high; containing more impurities, the price will drop.
Furthermore, the amount of production is also a major factor. If the origin is wide, the output is abundant, and the supply in the market is full, the price will tend to be flat; if the product is scarce, the quantity is limited, and the supply is in short supply, the price will rise.
Also, the season of purchase is also affected. In the season of strong demand, such as when demand in some pharmaceutical industries increases sharply, the price may rise; when demand is low, the price may drop slightly.
Overall, 3- (2-hydroxyethyl) indole in the market, if the quality is high, the yield is small, and when the demand is prosperous, the price per catty may reach tens of gold; if the quality is normal, the production is large and the demand is small, the price per catty may only be a few gold. However, the market conditions are ever-changing, and the price changes from time to time with many situations, making it difficult to determine its fixed number.