2-thiophenesulfonamide, 3-acetyl-5-chloro-

2-Thiophenesulfonamide, 3-acetyl-5-chlorine, is a compound in organic chemistry. Its physical properties are crucial, and it is related to many chemical processes and practical applications.
Looking at its morphology, under room temperature and pressure, or in the state of white to light yellow crystalline powder, it is delicate and uniform in quality, and has a regular shape as far as the eye can see. This morphology is more convenient for storage and access, and it is easy to weigh and operate.
When it comes to melting point, it is about a certain temperature range. This characteristic is one of the important indicators for identifying this compound. When the temperature rises near the melting point, the lattice structure of the compound gradually disintegrates, slowly melting from the solid state to the liquid state. The temperature in this process is relatively stable, like a checkpoint, accurately marking the point of its physical state transition.
In terms of solubility, in organic solvents, such as common ethanol, acetone, etc., show a certain solubility. The polarity of ethanol is in line with the partial structure of the compound, and the intermolecular force prompts it to dissolve into it to form a uniform solution; however, in water, the solubility is very small. Due to the large difference between the polarity of water and the overall polarity of the compound, the interaction is difficult to overcome the original attractive force between molecules, so it is difficult to dissolve.
Its density is also an inherent property. Under certain conditions, it has a specific value to characterize the mass of the substance contained in the unit volume. This value is of great significance in the process of chemical production, such as the ratio of materials and the design of the reaction system. It is related to whether the reaction can proceed as expected.
Furthermore, the compound may have a certain odor, or a weak special odor. Although it is not strong and pungent, it is also one of its physical properties. In actual operation and contact, it can be perceived by humans and is also helpful for preliminary identification and judgment.
In summary, the physical properties of 2-thiophenesulfonamide and 3-acetyl-5-chloride, from morphology, melting point, solubility, density to odor, are all important dimensions for understanding this compound, and are indispensable in the fields of chemical research and production practice.

3-Acetyl-5-chloro-2-thiophenesulfonamide, this substance is white to pale yellow crystalline powder. Its properties are stable, and it is difficult to react without special conditions at room temperature and pressure.
In terms of solubility, its solubility in water is very small, but it can be soluble in some organic solvents, such as dichloromethane, N, N-dimethylformamide. This is because the molecular structure of the substance contains polar groups, which can interact with organic solvents through intermolecular forces to enhance dissolution.
From the perspective of chemical activity, the sulfonamide group, acetyl group and chlorine atom in its structure give it a variety of reactivity. The nitrogen atom in the sulfonamide group has lone pair electrons, which can be used as a nucleophilic reagent to participate in the reaction; the carbonyl group of the acetyl group is electrophilic and can be attacked by nucleophilic reagents; while the chlorine atom is a good leaving group, which is easily replaced in nucleophilic substitution reactions.
For example, under suitable basic conditions, the chlorine atom can be replaced by nucleophilic reagents such as hydroxyl and amino groups, and then a series of derivatives can be prepared. At the same time, the sulfonamide group can also complex with metal ions to form complexes with specific properties. This compound is often used as a key intermediate in the field of organic synthesis to construct more complex organic molecular structures, and has important uses in pharmaceutical chemistry, materials science, and many other aspects.

2-Thiophenesulfonamide, 3-acetyl-5-chlorine, has a wide range of uses. In the field of medicine, it is often used as a key intermediate to help synthesize specific drugs. For example, when developing new drugs for specific diseases, with its unique chemical structure, it can precisely act on the lesion target, help improve the efficacy of drugs and relieve patients' diseases.
In the chemical industry, it is also an important raw material. It can participate in the preparation of a variety of fine chemicals, adding unique properties to chemical products. For example, it can make certain materials have special chemical stability or physical properties to meet the needs of different industrial scenarios.
In scientific research and exploration, as a basic chemical substance, it provides scientists with assistance in studying new reaction pathways and compound properties. By exploring its reaction laws, it is expected to open up new chemical synthesis methods and promote the frontier development of chemical science. With its diverse characteristics, this compound plays an indispensable role in many fields and continues to contribute to human life and scientific progress.

To prepare 2-thiophene sulfonamide and 3-acetyl-5-chlorine, there are three methods.
One is the method of starting the halogenation reaction. First take thiophene as the group, introduce sulfonamide group by the method of sulfonylation to obtain thiophene sulfonamide. Then add acetyl group to the thiophene ring at a suitable check point by the method of acetylation. Finally, the halogenation reaction is carried out, and the chlorine atom is introduced at a specific position. This process requires careful selection of halogenation reagents and conditions to achieve the purpose of precise positioning of chlorination. Halogenation reagents such as N-chlorosuccinimide (NCS) are selected according to the reaction system and the reaction temperature and time. < Br >
The second is to start with acetylation. First acetylation of thiophene, then sulfonylation to enter the sulfonamide group, and finally halogenation. This change in order may affect the selectivity of the reaction check point and the purity of the product. During acetylation, select suitable acetylation reagents and catalysts, such as acetic anhydride and anhydrous aluminum trichloride, and control the reaction conditions so that the acetyl group is connected at the desired position. The subsequent sulfonylation and halogenation steps also need to adjust the reagents and conditions according to the characteristics of the previous product.
The third is the method of combining halogenation and acetylation. Thiophene is first halogenated and acetylated at the same time or in close contact with each other to obtain thiophene derivatives containing chlorine and acetyl groups, and then sulfonylated to obtain the target product. This requires fine study of the interaction between each step of the reaction, optimize the reaction conditions, and ensure that each step of the reaction is smooth and the product reaches the expected structure and purity.
All methods have advantages and disadvantages. In actual operation, it is necessary to weigh and choose according to many factors such as the availability of raw materials, reaction cost, product purity and yield.

I don't know what you said about the price of 2 - thiophenesulfonamide, 3 - acetyl - 5 - chloro in the market. However, if you want to know its price, you can inquire at various chemical trading platforms and chemical raw material suppliers. Or you can send people to the chemical market, visit the merchants, and ask their prices, so that you can get a more accurate price range.
Or search online, look at the prices quoted by each supplier, but you need to pay attention to the impact of its specifications, purity and other factors on the price. Different purity, packaging, purchase quantity, prices are different.
And the market price often fluctuates due to changes in supply and demand, raw material costs, production processes, etc., and it is difficult to have a constant price. If you want to obtain an accurate price, you can obtain an approximate price range by inquiring and comparing multiple parties according to the current actual market situation.