2-Thiophenepropanoic acid methyl ester

2-%E5%99%BB%E5%90%A9%E4%B8%99%E9%85%B8%E7%94%B2%E9%85%AF%E8%80%85, it is the same, and its function is the same. In the Tao, its main uses are three.
First, it can be used to relieve pain. People who are subject to evil invasions, pain, body soreness, 2-%E5%99%BB%E5%90%A9%E4%B8%99%E9%85%B8%E7%94%B2%E9%85%AF%E5%8F%AF%E6%B2%BB%E6%84%9F%E5%86%92%E6%80%A7%E7%83%AD%E7%97%87, can make the body smooth and relieve the pain of the body. Such as spring and spring, the body can not be removed. Ancient people encountered such symptoms, and often treated with this.
Second, it can be used as an antidote. The disease of the body invades the limb, causing pain, weakness, and unfavorable flexion and extension. 2-%E5%99%BB%E5%90%A9%E4%B8%99%E9%85%B8%E7%94%B2%E9%85%AF%E5%8F%AF%E9%99%A4%E9%A3%8E%E6%B9%96%E4%B9%8B%E7%82%8E, so that the disease of the limb can be improved. Its effect is as good as that of the limb, so that the limb is heavy and comfortable.
Third, it also plays a role in the prevention and treatment of cardiovascular diseases. This can inhibit the aggregation of platelets and reduce the risk of thrombosis. Cardiovascular diseases, thrombosis, 2-%E5%99%BB%E5%90%A9%E4%B8%99%E9%85%B8%E7%94%B2%E9%85%AF%E5%A6%82%E5%BE%81%E9%98%B2%E9%99%A4%E9%A3%8E%E9%99%A9, and cardiovascular communication.
It is good to 2-%E5%99%BB%E5%90%A9%E4%B8%99%E9%85%B8%E7%94%B2%E9%85%AF%E5%9C%A8%E8%8D%AF%E7%95%85%E4%B8%AD%E6%9C%89%E8%87%AA%E5%B7%B1%E7%9A%84%E4%B8%BB%E8%A6%81%E4%BD%BF%E7%94%A8%E9%80%94, or relieve pain, or resist, or prevent cardiovascular diseases.

2-%E5%99%BB%E5%90%A9%E4%B8%99%E9%85%B8%E7%94%B2%E9%85%AF is a class of organic compounds. Its physical properties are quite characteristic, as follows:
Looking at its properties, under room temperature and pressure, 2-%E5%99%BB%E5%90%A9%E4%B8%99%E9%85%B8%E7%94%B2%E9%85%AF mostly in the shape of a liquid state. This is due to its moderate intermolecular force, not as close as a solid state, nor as discrete as a gaseous state. And its color is transparent and clear, like a mountain spring, without the slightest impurities, pure and free of impurities.
Smell its smell, with a special fragrance, but this fragrance is not rich and pungent, but elegant and unique. It smells like being in a strange garden, fresh and pleasant. This unique smell is also one of its important physical properties.
When it comes to density, it is lighter than water. If it is placed in the same place with water, it can be seen that it floats leisurely on the water surface, like a boat in a blue wave. This characteristic is due to its molecular structure and composition, so that its unit volume mass is less than the mass of water.
As for solubility, 2-%E5%99%BB%E5%90%A9%E4%B8%99%E9%85%B8%E7%94%B2%E9%85%AF in organic solvents, such as ethanol and ether, they can be well miscible, just like the water of fish, the two blend with each other, indistinguishable from each other. However, the solubility in water is very small, and the two meet, just like oil and water, they are distinct and difficult to blend. This is due to the large difference between the polarity of the compound molecule and the polarity of the water molecule.
Its boiling point is also considerable, in a specific temperature range. When the external temperature rises to the corresponding boiling point, the 2-%E5%99%BB%E5%90%A9%E4%B8%99%E9%85%B8%E7%94%B2%E9%85%AF gradually changes from liquid state to gaseous state, the distance between molecules increases, and the movement becomes more free. This boiling point characteristic has important guiding significance in the process of separation and purification.

Ethyl 2-% pentanoate, also known as ethyl alpha-acetyl butyrate, is an important raw material in organic synthesis. It has the following chemical properties:
1. ** Hydrolysis reaction **: Under acid or base catalysis conditions, 2-% pentanoate ethyl ester can undergo hydrolysis. In acidic media, it slowly hydrolyzes to produce 2-% pentanoic acid and ethanol. In alkaline environments, the hydrolysis rate is significantly accelerated, resulting in corresponding carboxylates and ethanol, and then acidified to obtain 2-% pentanoic acid. This hydrolysis reaction is often used to prepare 2-% pentanoic acid and its derivatives. For example, 2-% pentanoate ethyl ester is treated with an aqueous solution of sodium hydroxide, and 2-% pentanoate sodium salt can be obtained by heating and refluxing, and then acidified with dilute hydrochloric acid to obtain 2-% pentanoic acid.
2. ** Ester condensation reaction **: The carbonyl α-hydrogen of 2-% pentanoate ethyl ester has a certain acidity, and under the action of strong bases, it can condensate with another molecule of ester, that is, the clayson ester condensation reaction. This reaction can form carbon-carbon bonds to generate more complex β-ketoate compounds. For example, under the action of sodium ethanol, 2-% ethyl pentanoate is condensed with ethyl acetate to obtain compounds containing multiple carbonyl groups, providing an effective way for the synthesis of polyketones and heterocyclic compounds.
3. ** Reduction reaction **: Its carbonyl group can be reduced by various reducing agents. Using lithium aluminum hydride (LiAlH) as a reducing agent, the carbonyl group of 2-% ethyl pentanoate can be reduced to alcoholic hydroxyl groups to generate corresponding alcohols. If a milder reducing agent, sodium borohydride (NaBH), is used, the main ketone carbonyl group is reduced, while the ester group is not affected, and β-hydroxyl esters can be selectively obtained.
4. ** Halogenation Reaction **: Affected by the dual influence of carbonyl and ester groups, 2-% ethyl pentanoate carbonyl α-hydrogen has high activity, and under appropriate conditions, it is prone to halogenation reactions. For example, when acid catalyzed and there are halogens, α-hydrogen can be gradually replaced by halogens to form halogenated derivatives. These halogenated derivatives can be used as intermediates in organic synthesis for the introduction of other functional groups.

To prepare ethyl 2-valerynate, you can follow the following methods:
First, start with propane. Shilling propane reacts with sodium metal in liquid ammonia to obtain sodium propane. This is to take advantage of the acidity of hydrogen propane in propane, which can be replaced with strong base sodium metal. Then sodium propane reacts with 1-bromopropane, which is a nucleophilic substitution reaction. The propane group attacks the alpha-carbon of 1-bromopropane as a nucleophilic reagent, and the bromine ion leaves to form 2-pentyne. Next, 2-pentyne reacts at a specific temperature and pressure in the presence of carbon dioxide and a suitable catalyst, introducing a carboxyl group to obtain 2-valerynic acid. Finally, the esterification reaction between 2-pentyne acid and ethanol is catalyzed by concentrated sulfuric acid, and heating prompts the reaction to proceed to the right to obtain ethyl 2-pentyne acid. This series of reaction steps is clear, and the reaction conditions of each step are relatively clear, which can effectively achieve the synthesis of the target product.
Second, 1-pentyne is used as the starting material. 1-pentyne first reacts with carbon dioxide under a specific catalyst and suitable reaction conditions, and a carboxyl group is introduced at the end of the alkyne bond to form pentyne acid. Subsequently, the pentyne acid and ethanol are esterified under the condition of catalyzed by concentrated sulfuric acid and heated to form ethyl valerate. Then, under the action of liquid ammonia and sodium metal, ethyl valerate undergoes a partial reduction reaction of alkynes, and the carbon-carbon triple bond is reduced to the carbon-carbon double bond, and 2-ethyl valerate can be obtained. This route cleverly uses the various reaction characteristics of alkynes to gradually construct the structure of the target product.
Third, start with 1-bromopropane and diethyl malonate. 1-bromopropane and diethyl malonate undergo nucleophilic substitution reaction under the action of sodium alcohol. Methylene carbon of diethyl malonate attacks α-carbon of 1-bromopropane as the nucleophilic center, and bromine ions leave. After that, the product is hydrolyzed, decarboxylated and other steps to obtain valeric acid. Valeric acid is brominated, and bromine atoms are introduced at the α-position to obtain α-bromovaleric acid. Then α-bromovaleric acid and acetylene undergo nucleophilic substitution reaction under the action of alkali, and ethylene groups are introduced, and then esterification reaction, ethyl 2-valerate can be obtained. Although this path is a little complicated, through the clever use of various organic reactions, the target product can also be successfully synthesized.

Ethyl 2-% pentanedioate should be paid attention to when storing and transporting.
The first word of storage is that this substance should be placed in a cool, dry and well-ventilated place. Because of its chemical properties, if it is placed in a high temperature and humid place, it is easy to cause chemical reactions and cause quality damage. It should be kept away from fires and heat sources to prevent the risk of fire or explosion. In addition, it should be stored separately from oxidizing agents, acids, and bases, and must not be mixed. It is easy to react violently with such substances. And suitable materials should be prepared to contain leaks. If there is a leak, it can be disposed of in time to avoid greater harm.
As for transportation, caution is also required. Before transportation, make sure that the container is well sealed and free of leakage. During transportation, be sure to prevent exposure to the sun, rain, and high temperature. Vehicles used during transportation should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. It is strictly forbidden to mix with oxidants, acids, alkalis, etc. Mixed transportation should be prevented on the way to bumps and shocks to avoid material leakage caused by damage to the container. Load and unload lightly to prevent damage to packaging and containers. Employees should also be familiar with its characteristics and emergency treatment methods. In case of emergencies, they can respond quickly and properly to ensure the safety of the transportation process.