2 Thiophenecarboxylic Acid
quinoline thiophene imidazole thiazole

2-Thiophenecarboxylic acid

Taiy Chemical

    Specifications

    HS Code

    373294

    Chemical Formula C5H4O2S
    Molar Mass 128.15 g/mol
    Appearance White to off - white solid
    Melting Point 133 - 137 °C
    Boiling Point 282 - 283 °C
    Solubility In Water Slightly soluble
    Solubility In Organic Solvents Soluble in ethanol, ether, etc.
    Acidity Weak acid
    Odor Characteristic odor
    Stability Stable under normal conditions

    As an accredited 2-Thiophenecarboxylic acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing
    Storage
    Shipping
    Free Quote

    Competitive 2-Thiophenecarboxylic acid prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615365036030 or mail to info@alchemist-chem.com.

    We will respond to you as soon as possible.

    Tel: +8615365036030

    Email: info@alchemist-chem.com

    General Information
    Where to Buy 2-Thiophenecarboxylic acid in China?
    As a trusted 2-Thiophenecarboxylic acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-Thiophenecarboxylic acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 2-thiophenecarboxylic acid?
    2-%E5%99%BB%E5%90%A9%E7%94%B2%E9%85%B8%E8%80%85, known as 2-methylbutyric acid, its physical properties are special.























    < br The boiling temperature is 176-177 ℃, and the high boiling temperature of the phase indicates that the molecular force has a certain degree, and high energy is required to make it melt from the liquid.
    2-%E5%99%BB%E5%90%A9%E7%94%B2%E9%85%B8%E7%9A%84 density is slightly higher than that of water, which is 0.93 g/cm ³. Therefore, if it is high in water, it will sink in water due to its density difference. And its solubility has certain characteristics. It is slightly soluble in water, and it can be widely soluble in ethanol, ether, etc. This property makes it possible to extract, separate, or react with specific solutions in the synthesis and phase engineering.
    In addition, 2-%E5%99%BB%E5%90%A9%E7%94%B2%E9%85%B8%E5%85%B7 has a certain degree of performance, and the boiling time is not low, but in the open environment, it is still difficult to change, and it is required to be properly sealed and stored during storage and use to avoid loss or impact on its performance.
    What are the chemical properties of 2-thiophenecarboxylic acid?
    2-% pentenedioic acid, also known as 2-pentene-1,5-diacid, is an important organic compound. It has the following chemical properties:
    ** Acidic **: This compound contains two carboxyl groups (-COOH). Due to the strong electronegativity of oxygen atoms in the carboxyl group, the hydrogen-oxygen bond electron cloud is biased towards oxygen, and hydrogen is easily dissociated in the form of protons, so it is acidic. In water, ionization can occur: HOOCCH = CHCH -2 COOH~ HOOCCH = CHCH -2 COO~ + H 🥰, which can neutralize with bases. For example, when reacting with sodium hydroxide: HOOCCH = CHCH -2 COOH + 2NaOH → NaOOCCH = CHCH -2 COONa + 2H 2O O, the corresponding carboxylate and water are generated.
    ** Electrophilic addition reaction **: The molecule contains carbon-carbon double bonds, and the π bond electron cloud is exposed, which has a high electron cloud density and is vulnerable to electrophilic attack. If it reacts with bromine water, the bromine molecule is polarized, and the positively charged end attacks the double bond to form a bromide ion intermediate. Then the bromine negative ion attacks from the back to generate 2,3-dibromoglutaric acid: HOOCCH = CHCH -2 COOH + Br ³ → HOOCCHBrCHBrCH -2 COOH. When adding hydrogen to hydrogen chloride, following the Markov rule, hydrogen is added to the carbon with more hydrogen-containing double bonds to generate 2-chloroprene acid: HOOCCH = CHCH -2 COOH + HCl → HOOCCH -2 CHClCH -2 COOH.
    ** Esterification reaction **: Under the catalysis of concentrated sulfuric acid and heating conditions, the carboxyl group can undergo esterification reaction with alcohol. Taking the reaction with ethanol as an example, the hydroxyl group in the carboxyl group is combined with the hydrogen in the ethanol to form water, and the rest is connected to form an ester: HOOCCH = CHCH ² COOH + 2C ² H OH $\ underset {\ triangle} {\ overset {concentrated H ² S O ₄}{=\!=\!=}}$ C ³ H OOCCH = CHCH -2 COOC ² H + 2H ³ O to form diethyl pentanedioate.
    ** Polymerization reaction **: Due to the carbon-containing carbon double bond and carboxyl group, polymerization reaction can occur. The double bonds can be opened and interconnected to form long chains, and the carboxyl groups can also be dehydrated and condensed to form bulk or linear polymers, which have potential application value in the field of polymer material synthesis.
    What are the main uses of 2-thiophenecarboxylic acid?
    2-% pentanedioic acid, that is, α-ketoglutaric acid, has the most important function in biochemical metabolism. Although this substance is not detailed in "Tiangong Kaiwu", it can be known from ancient theory and modern biochemical knowledge.
    α-ketoglutaric acid is also a key intermediate of the tricarboxylic acid cycle. The tricarboxylic acid cycle, the pivotal link of cell respiration, is related to the complete oxidation of the three major nutrients of sugar, fat and protein to release energy for the needs of cells. In the cycle, α-ketoglutaric acid is first converted into succinyl-coenzyme A through enzymatic reaction. This process is accompanied by energy release and generates a high-energy compound GTP, which can be converted into ATP, which is the "currency" for the energy of cell life activities.
    In the metabolism of amino acids, α-ketoglutaric acid is an amino receptor and participates in the transamination. The amino groups of many amino acids can be transferred to α-ketoglutaric acid to generate glutamic acid, which itself becomes the corresponding α-ketoglutaric acid. In this process, one is the beginning of amino acid catabolism, and the other is that glutamic acid can be further metabolized, or participate in urea synthesis to expel ammonia to maintain nitrogen balance in the body; or deammonia through oxidation, and then enter the tricarboxylic acid cycle for energy supply.
    And α-ketoglutaric acid bridges between nitrogen metabolism and carbon metabolism. The nitrogen source is metabolized in the form of amino acids, and through transamination, α-ketoglutaric acid is related to the carbon skeleton and amino group, so that amino acid metabolism is interconnected with sugar and lipid metabolism, and the metabolism of the body is coordinated.
    In addition, α-ketoglutaric acid also affects the fermentation of some microorganisms. It can be used as a fermentation regulatory factor to affect the generation In glutamic acid fermentation, an appropriate amount of α-ketoglutaric acid can promote glutamic acid synthesis, because α-ketoglutaric acid is a precursor to glutamic acid synthesis, sufficient substrates can promote the forward reaction and increase glutamic acid production.
    What are the synthesis methods of 2-thiophenecarboxylic acid?
    To prepare 2-cyanoacetic acid, the methods are as follows:
    First, chloroacetic acid and sodium cyanide are used as materials. First, take chloroacetic acid, dissolve it in an appropriate amount of water, form a chloroacetic acid solution, slowly drop into the sodium hydroxide solution, adjust its pH to alkaline, and in this step make the chloroacetic acid into a sodium salt to increase its nucleophilic substitution activity. Then prepare the sodium cyanide into a solution, and add the above sodium chloroacetic acid salt solution dropwise under suitable temperature and stirring. Cyanide ions have strong nucleophilicity and can replace chlorine atoms to obtain sodium 2-cyanoacetic acid. After the reaction, dilute acid is used to adjust the pH to acidic, so that sodium 2-cyanoacetic acid is converted into 2-cyanoacetic acid, and then purified by extraction and distillation to obtain a pure product. This is a classic nucleophilic substitution method. The raw materials are easy to obtain, but sodium cyanide is highly toxic. The operation must be careful to prevent leakage and poisoning.
    Second, glycine is used as the starting material. Glycine reacts with sodium nitrite and dilute sulfuric acid to form a diazonium salt intermediate. The diazonium base is unstable. Under appropriate conditions, it is converted into 2-cyanoacetic acid through intramolecular rearrangement and denitrification. This process requires controlling the reaction temperature and pH to ensure a stable reaction. Diazonium salts have high reactivity and are prone to side reactions, so the reaction conditions are strict. However, this raw material is relatively safe and less toxic than sodium cyanide.
    Third, acetonitrile is used as the raw material. Acetonitrile first reacts with formaldehyde under the action of an alkaline catalyst to obtain cyanoethanol. Then through an oxidation step to oxidize cyanoethanol to 2-cyanoacetic acid with a suitable oxidant, such as manganese dioxide, etc. This path has a little more steps, but the raw materials are common and the reaction is relatively mild. However, the oxidation step requires the selection of suitable oxidants and conditions to ensure product selectivity and yield.
    What are the precautions for 2-thiophenecarboxylic acid during storage and transportation?
    For 2-% pentenedioic acid, during storage and transportation, several precautions should not be ignored.
    The first thing to understand is that its chemical activity is active and it is easy to react with other things. When storing, choose a cool, dry and well-ventilated place, away from direct sunlight and heat sources. Due to high temperature, it may accelerate decomposition, or cause other chemical reactions, which will damage its quality, and even pose a risk of safety.
    Second, the packaging must be tight. Choose the appropriate packaging material to prevent its leakage. Take glass containers as an example, they must be thick-walled and corrosion-resistant, supplemented by a sealing lid to prevent air and moisture from invading. If using plastic containers, it is also necessary to consider the material's resistance to it to avoid swelling and penetration.
    Furthermore, during transportation, shock protection and anti-bump are very important. Due to its chemical properties, violent vibration or package damage can cause leakage. Therefore, it should be padded with soft cushioning materials to ensure smooth transportation. And transportation vehicles should be prepared for emergency disposal. In case of leakage, they can be dealt with in time.
    In addition, 2-% pentanedioic acid may be corrosive to a certain extent. When operating and contacting, protective equipment is essential. Operators should wear protective clothing, protective gloves and goggles to prevent it from touching the skin and eyes and causing chemical burns.
    In addition, things that coexist with 2-% pentenedioic acid in the same room should also be carefully selected. Do not mix or mix with strong oxidants, strong bases, etc. It encounters with strong oxidants or undergoes a violent oxidation reaction; when it encounters with strong bases, it is easy to cause neutralization reactions, which may cause danger.
    In short, the process of storage and transportation of 2-% pentenedioic acid, from the environment, packaging, to operation protection, and item compatibility, is related to safety and quality. It must be done carefully to ensure safety.