2-thiophenecarboxylic acid, 4-fluoro-

4-Fluoro-2-thiophenecarboxylic acid is a kind of organic compound. It has specific physical properties and is described in detail as follows:
Under normal temperature and pressure, it is mostly white to light yellow crystalline powder. This form is easy to identify and is a significant feature of its appearance.
When it comes to the melting point, it is between 130-134 ° C, and the melting point is established. During the heating process, when the temperature reaches this range, the substance gradually changes from solid state to liquid state. This property is of great significance in material identification and purity judgment.
As for solubility, 4-fluoro-2-thiophenecarboxylic acid is slightly soluble in water, but it exhibits good solubility in organic solvents such as ethanol, dichloromethane, N, N-dimethylformamide (DMF), etc. This difference in solubility makes it possible to select suitable solvents according to their characteristics during chemical synthesis, separation and purification, etc., in order to achieve the desired experimental purpose. For example, in some reaction systems, DMF can be used as a solvent to promote the reaction to proceed more efficiently.
In addition, the density of the substance is 1.503g/cm ³. As one of the inherent properties of the substance, density is helpful for accurate measurement and calculation in specific scenarios. In terms of storage and transportation, its properties are relatively stable, but due to its chemical properties, it still needs to be stored in a dry, cool and well-ventilated place to avoid contact with strong oxidants, strong bases and other substances to prevent chemical reactions from occurring and affecting its quality and performance.
These are the main physical properties of 4-fluoro-2-thiophenecarboxylic acid. Understanding these properties is of great significance in many fields such as chemical research and industrial production.

4-Fluoro-2-thiophenecarboxylic acid is one of the organic compounds. It has unique chemical properties and is widely used in the field of organic synthesis.
This compound is acidic, because it contains a carboxyl (-COOH) functional group, the carboxyl group can release protons under suitable conditions, exhibit acidic properties, and can neutralize with bases to generate corresponding salts and water.
Its thiophene ring structure gives special electronic effects and aromatics. The thiophene ring is a five-membered heterocycle with certain stability and electron delocalization properties. The introduction of fluorine atoms has a significant impact on the distribution and spatial structure of molecular electron clouds. Fluorine atoms are highly electronegative and have a strong electron-absorbing induction effect, which can change the electron cloud density around the thiophene ring and carboxyl groups, affecting the reactivity and chemical properties.
In chemical reactions, the carboxyl group of 4-fluoro-2-thiophenecarboxylic acid can participate in many reactions. For example, it can be esterified with alcohols. Under acid catalysis, the carboxyl group dehydrates and condensates with the alcohol hydroxyl group to form ester compounds. This reaction is often used in organic synthesis to prepare esters with specific structures for applications in perfumes, drugs and other fields.
At the same time, due to the presence of fluorine atoms, the compound can participate in nucleophilic substitution reactions and so on. When fluorine atoms are used as leaving groups, they can be replaced under the action of suitable nucleophiles to form new carbon-heteroatomic bonds or carbon-carbon bonds, providing a way for the synthesis of more complex organic molecules.
In addition, its aromaticity allows molecules to participate in some aromatic ring-based reactions, such as the Friedel-Crafts reaction, which can introduce other functional groups on the thiophene ring to further enrich the molecular structure and expand its application in organic synthesis and materials science.

4-Fluoro-2-thiophenecarboxylic acid has a wide range of uses. In the field of medicine, it is often a key intermediate, helping to create many special drugs. The unique structure of the thiophene ring and the fluorine atom endows the drug with different activities and characteristics. For example, in the development of antibacterial drugs, this substance can optimize the affinity of the drug to bacterial targets and enhance the antibacterial efficacy.
In the field of materials science, 4-fluoro-2-thiophenecarboxylic acid also has important functions. It can be used to prepare materials with special photoelectric properties, and has great potential in the fields of organic Light Emitting Diode (OLED) and solar cells. Its structure helps to regulate the electronic transport and optical properties of materials and improve the performance of devices.
Furthermore, in the field of agricultural chemistry, it can be used as a raw material for the synthesis of new pesticides. With its unique chemical structure, the synthesized pesticides may have high efficiency, low toxicity and environmental friendliness, which is of great significance for pest control and crop protection.
In addition, in the field of organic synthetic chemistry, it is often used as a starting material or intermediate. Through various chemical reactions, various complex organic molecular structures are constructed, contributing to the development of organic synthetic chemistry. In short, 4-fluoro-2-thiophenecarboxylic acid plays an indispensable role in many important fields and has made great contributions to promoting the progress of related industries.

There are several ways to prepare 4-fluoro-2-thiophenecarboxylic acid.
First, 4-fluorothiophene is used as the starting material. First, it is combined with a suitable halogenating agent, such as N-bromosuccinimide (NBS), under suitable reaction conditions, such as in an inert solvent (such as carbon tetrachloride), in the presence of an initiator (such as benzoyl peroxide) and under heating or lighting conditions, the bromination reaction is carried out, and the bromine atom is introduced at the 2-position of the thiophene ring to obtain 4-fluoro-2-bromothiophene. After that, the bromide is reacted with metal magnesium to form a Grignard reagent. For example, in anhydrous ether or tetrahydrofuran solvent, the reaction at low temperature forms 4-fluoro-2-thiophene magnesium bromide. Then the Grignard reagent is reacted with carbon dioxide, which can be passed into dry carbon dioxide gas. After the reaction is completed, it can be acidified to obtain 4-fluoro-2-thiophenecarboxylic acid.
Second, it can be started from 2-thiophenecarboxylic acid. Using suitable fluorinating reagents, such as Selectfluor, etc., in a suitable reaction system, such as in an organic solvent (such as acetonitrile), and in the presence of a base (such as potassium carbonate), the 4-position of the thiophene ring is fluorinated to directly prepare 4-fluoro-2-thiophenecarboxylic acid. This method is relatively direct and avoids the complexity caused by the multi-step reaction, but attention should be paid to the selection of fluorinating reagents and the control of reaction conditions to ensure the selectivity and yield of the reaction.
Third, 4-fluoro-2-methylthiophene can also be used as a raw material. First, through a mild oxidation reaction, such as the use of potassium permanganate or potassium dichromate oxidizing agents, in a suitable reaction medium (such as acidic aqueous solution or a mixed system of organic solvent and water), methyl is oxidized to carboxyl groups to prepare 4-fluoro-2-thiophenecarboxylic acid. However, this process needs to pay attention to the degree of oxidation to prevent excessive oxidation from causing product loss or forming by-products.
The above methods have advantages and disadvantages. According to the actual situation, such as the availability of raw materials, cost, and requirements for product purity, etc., choose the suitable one for the preparation of 4-fluoro-2-thiophenecarboxylic acid.

At present, the price of 2-thiophenecarboxylic acid and 4-fluorine in the city is not fixed. The price of the cover often changes due to various reasons, such as the abundance of production sources, the growth and decline of demand, the new changes in manufacturing technology, the rise and fall of the market, and even the relaxation of government orders.
In the past, if the material was widely available and the demand was scarce, the price would be inexpensive; if the place of origin was disastrous, resulting in a reduction in production, and there were many seekers, the price would be high. And in today's world, the technology of chemical industry is changing day by day. If there is a new law to make this product, the cost may drop, and the price will also change accordingly.
Also, the area of the city is different, and the price is also different. In the prosperous cities, the trade and goods converge, the competition is fierce, and the price may be leveled; in remote places, the transshipment of goods is difficult, and the price may increase.
Looking at the market conditions, if you want to know the exact price of 2-thiophenecarboxylic acid and 4-fluorine, you must widely observe the sales of various merchants in the market, study the recent price changes in detail, and take into account the causes of various influences, in order to obtain the approximate price range. However, the price is ultimately difficult to predict, and often fluctuates with market conditions.