2-Thiophenecarboxaldehyde, 3-methoxy-

3-Methoxy-2-thiophenylformaldehyde, which is widely used. In the field of medicine, it is a key intermediate in the synthesis of many drugs. For example, it can be used through a series of delicate chemical reactions to prepare drugs with specific curative effects, or to design and synthesize new drug molecules for specific disease targets, which play an important role in the treatment of diseases.
In the field of materials science, it also has unique applications. It can participate in the synthesis of materials with special properties, such as giving materials specific optical and electrical properties, so as to meet the needs of materials with special properties in fields such as optoelectronic devices and sensors.
In the field of organic synthetic chemistry, 3-methoxy-2-thiophene formaldehyde, as an important organic raw material, can trigger various types of organic reactions with its unique chemical structure, expand the synthesis path of organic compounds, and help chemists create more complex and functional organic molecules. This promotes the continuous development of organic synthetic chemistry and provides a solid material foundation and technical support for the development of various related fields.

3-Methoxy-2-thiophenylformaldehyde, this is an organic compound. Its physical properties are as follows:
Viewed at room temperature, it may be a colorless to light yellow liquid, but it also depends on the purity and environmental factors, or it may be nearly colorless and transparent.
Smell it, it has a special organic aldehyde smell, but this smell is not as pungent as the common aldehyde, but has a unique heterocyclic compound smell.
In terms of melting and boiling point, the melting point is about -18 ° C, and the boiling point is between 220-222 ° C. This boiling point implies that it needs a higher temperature to boil at normal pressure, reflecting the intermolecular force. < Br >
Solubility, slightly soluble in water, cover because of its molecular structure containing hydrophobic thiophene ring and methoxy group, weak ability to form hydrogen bonds with water. But soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc., due to the principle of similar phase dissolution, it has a similar force to organic solvent molecules.
The density is slightly higher than that of water, about 1.22g/cm ³. If mixed with water, it will sink to the bottom of the water.
This compound is widely used in the field of organic synthesis due to its unique physical properties, and can be used as a medicine, pesticide and material intermediate.

3-Methoxy-2-thiophene formaldehyde is an organic compound with special chemical properties. Its structure contains thiophene ring, methoxy group and aldehyde group, which endows it with various chemical activities.
In terms of physical properties, it is usually liquid or solid. Due to the methoxy group, it has a certain polarity, which affects its solubility in different solvents. It can dissolve some polar organic solvents, such as ethanol and acetone, but it is difficult to dissolve in non-polar solvents such as n-hexane.
In terms of chemical properties, aldehyde group is its active part and can undergo many reactions. If it can react with alcohols under acid catalysis to form an acetal structure, this reaction is often used in organic synthesis to protect the aldehyde group from other reagents under specific reaction conditions. At the same time, the aldehyde group can be oxidized, and treated with weak oxidants such as Torun reagent and Feilin reagent, the aldehyde group will be oxidized to a carboxyl group to generate 3-methoxy-2-thiophenecarboxylic acid, which is an important way to prepare such carboxylic acid compounds.
Furthermore, the thiophene ring also has a certain activity. Although it is more active than the benzene ring, its aromaticity makes it capable of electrophilic substitution. Methoxy group is the power supply group, which can increase the electron cloud density on the thiophene ring, which in turn affects the positional selectivity of electrophilic substitution reaction. Electrophilic reagents are more inclined to attack the ortho or para-site of methoxy group, such as halogenation, nitrification, sulfonation and other electrophilic substitution reactions can occur.
In addition, the bonding between atoms in 3-methoxy-2-thiophene formaldehyde determines its stability and reactivity, and the distribution of intramolecular electron clouds affects the ease of various reactions. Due to its unique chemical properties, it is widely used in the fields of medicine, pesticides, materials, etc., such as as as a key intermediate for the synthesis of specific drugs or functional materials.

The preparation of 3-methoxy-2-thiophene formaldehyde is an important task in chemical synthesis. To obtain this compound, it can be obtained from common starting materials through several delicate reactions.
The first step is often to start with a suitable thiophene derivative. For example, select a thiophene containing a modifiable group, which will lay the foundation for the subsequent introduction of methoxy and aldehyde groups.
The second step is to introduce methoxy. Choose a suitable methoxylating agent, such as methyl halide and base synergism. In a suitable solvent, such as a polar aprotic solvent, at a certain temperature and reaction time, the methoxylation reagent undergoes a nucleophilic substitution reaction with the thiophene derivative, and the methoxy group is successfully connected to the designated position of the thiophene ring. This process requires fine regulation of the reaction conditions. Due to high or low temperature and improper dosage of reagents, side reactions may occur or the yield is low.
The final step is to construct an aldehyde group. A mild formylation reaction is often used. A specific formylation reagent, such as Vilsmeier-Haack reagent composed of dimethylformamide and phosphorus oxychloride, reacts with a methoxy-containing thiophene intermediate. In a suitable reaction environment, the reagent interacts with the intermediate to generate an aldehyde group at a specific check point of the thiophene ring, and finally obtain 3-methoxy-2-thiophene formaldehyde.
The whole synthesis process, the monitoring of each step of the reaction is extremely critical. The reaction process and product purity can be confirmed by means of thin-layer chromatography and nuclear magnetic resonance. When purifying the product, techniques such as recrystallization and column chromatography are commonly used to obtain high-purity target compounds to meet the needs of subsequent experiments or applications.

I don't know what the price range of 2-thiophene formaldehyde and 3-methoxy is in the market. However, if you want to know its price, you can use various paths to find it.
First, you can visit the special website for chemical raw material trading. Such websites often collect price information of many chemical products, and many suppliers list their prices, or you can get the price range of 2-thiophene formaldehyde and 3-methoxy based on this.
Second, you can consult chemical product distributors. They have been involved in this industry for a long time, have dealings with many manufacturers, and are familiar with various product market conditions. They can tell you the approximate price of 2-thiophene formaldehyde and 3-methoxy.
Third, the chemical exhibition is also the way to get the price. At the exhibition, chemical companies can gather to communicate directly with manufacturers, ask about the price of their products, and take the opportunity to observe the quality and characteristics of their products.
However, the price of raw materials is not constant, often due to the rise and fall of raw material prices, changes in market supply and demand, the difficulty of production processes, and the purity of products. If the price of raw materials is high, or the supply is insufficient due to a large increase in market demand, the price will rise; on the contrary, if the raw materials are abundant and the market demand is weak, the price may drop. And high purity of 2-thiophene formaldehyde, 3-methoxy group, the price may be higher than ordinary purity. To get an accurate price, you need to inquire more and consider comprehensively.