2-Thiopheneacrylic acid

2-Thiophene acrylic acid is quite useful among organic compounds. Its main uses can be roughly divided into the following ends.
First, in the field of medicine, it has a significant effect. Because it has certain biological activity, it can be used as a key intermediate in pharmaceutical synthesis. Through specific chemical reactions, it can be cleverly combined with other compounds to construct drug molecules with more complex structures. On this basis, drugs with antibacterial, anti-inflammatory and other effects can be developed, making great contributions to human health and well-being.
Second, in the field of materials science, it also has outstanding performance. 2-Thiophene acrylic acid can be used to prepare polymer materials with excellent properties due to its special structure. After polymerization, polymers with unique optical and electrical properties can be formed. Such polymers have wide application prospects in organic Light Emitting Diodes (OLEDs), solar cells and other fields. For example, in OLED manufacturing, it can optimize the luminous performance and improve the display effect.
Third, in the fine chemical industry, 2-thiophene acrylic acid is also an important raw material. It can be used to synthesize various fine chemicals, such as fragrances and dyes. In fragrance synthesis, it can give the product a unique aroma; in dye preparation, it can adjust the color, light and fastness of the dye to meet different industrial and life needs.
Therefore, 2-thiophene acrylic acid occupies an important position in many fields due to its various uses, and has made great contributions to promoting the development of related industries.

2-Thiophene acrylic acid, its physical properties are as follows:
This substance is mostly solid at room temperature, and its appearance is usually white to light yellow crystalline powder. It is like a fine powder and feels delicate to the touch. Its melting point is in a specific range, about 137-141 ° C. Within this temperature limit, it will gradually melt from solid to liquid, completing the phase transition.
2-Thiophene acrylic acid is slightly soluble in water, and its solubility in water is quite limited, and its acceptance in the water environment is not high. However, it is soluble in many organic solvents, such as ethanol, ether, acetone, etc. In ethanol, it can be well dispersed and dissolved, and it blends with ethanol molecules, showing good solubility, and the same is true in organic solvents such as ether and acetone.
Looking at its density, it has a certain value. Although it is not extremely heavy, it also has corresponding quality characteristics. Under specific conditions, each unit volume carries a specific mass. Its stability is still good under general conditions. It can maintain its own chemical structure and properties at room temperature and pressure without special chemical environment interference, and is not easy to cause violent chemical reactions on its own and change its own properties.
The influence of light on it cannot be ignored. Long-term exposure to strong light may trigger some subtle photochemical reactions, causing its properties to change slightly. If the humidity environment is too high, although it will not cause rapid deliquescence, it may affect the maintenance of its physical state to a certain extent, or cause some adhesion between the powders.

2-Thiophene acrylic acid, its chemical properties are quite rich. This is an organic compound with acidic properties. Because of its carboxyl group (-COOH), the group can release protons, exhibit acidic properties in water, and can neutralize with bases to form corresponding salts and water.
Its thiophene ring structure also has unique chemical activity. The thiophene ring is an electron-rich aromatic ring, which can undergo many electrophilic substitution reactions, such as halogenation, nitrification, and sulfonation. Electrophilic reagents easily attack the positions with high electron cloud density on the thiophene ring, and then generate various substitution products.
At the same time, the carbon-carbon double bonds in the molecule also endow it with diverse reactivity. Carbon-carbon double bonds can be used for addition reactions, such as addition with hydrogen to form saturated compounds, addition with halogens, hydrogen halides and other electrophilic reagents to form corresponding addition products. Under appropriate conditions, polymerization can also occur to form polymer compounds.
In addition, 2-thiophene acrylic acid can participate in a variety of organic synthesis reactions due to its multiple activity check points. As a key intermediate for constructing more complex organic molecular structures, it has important application value in pharmaceutical chemistry, materials science and other fields. Its chemical properties make it play an indispensable role in the stage of organic synthetic chemistry.

The synthesis method of 2-thiophene acrylic acid has been recorded in many books in the past, and this is a detailed description for you today.
First, the Knoevenagel condensation reaction is carried out with thiophene and malonic acid as raw materials in a pyridine solvent and catalyzed by piperidine. This reaction condition is mild, but the price of malonic acid is quite high, and the cost is its constraint.
Second, thiophene formaldehyde and diethyl malonate are used as starting materials. In an ethanol solvent and catalyzed by hexahydropyridine, the condensation produces 2- (2-thiophene) -diethyl malonate. The target product can be obtained after hydrolysis and decarboxylation. This path step is slightly complicated, but the raw materials are easy to purchase, and the yield is still good.
Third, thiophene formaldehyde and ethyl acetoacetate are used as raw materials. In ethanol solvent, under alkali catalysis, 3-oxo-3- (2-thiophenyl) propionate ethyl ester is first obtained, and then 2-thiophene acrylic acid is obtained by hydrolysis and decarboxylation. The reaction conditions of this method are easy to control, but the reaction process needs to be carefully operated to avoid the growth of side reactions.
Fourth, thiophene and acrylic acid are used as raw materials, and free radical addition reactions are carried out under the action of free radical initiators. This approach is simple, but the reaction selectivity needs to be carefully controlled to obtain the ideal yield.
All kinds of synthesis methods have their own advantages and disadvantages. Experimenters should weigh the cost of raw materials, reaction conditions, yield and other factors according to their own needs, and choose the appropriate method to achieve the purpose of synthesis.

The price of 2-thiophene acrylic acid in the market often varies depending on the quality, source, and quantity. In chemical markets, if you buy a small amount to explore experimentally, the price may be higher. Looking at the price of chemical materials in the past, it ranged from a few yuan per gram to tens of yuan. If you buy in batches and use it in industrial manufacturing, etc., it is better to consider more, and the price per gram may drop to about one yuan, or even lower.
The reason for this is that when the quantity is small, the supplier needs to take into account the cost of small batch transactions, such as packaging, transportation, etc., which are all shared in the price, so the price is high; and if you buy in large quantities, the supplier's production efficiency will be improved and the cost will be controlled, so the price can be reduced. The difference in quality is also the main reason. Those with high purity and few impurities are often higher than ordinary products.
However, the chemical industry is changing rapidly, and the price of raw materials, supply and demand conditions, and policy regulations can all cause their prices to fluctuate. To know the real-time price, when consulting chemical raw material suppliers, or exploring chemical trading platforms, you can get accurate numbers.