2-Thiopheneacethyl chloride

2-Thiophene acetyl chloride is a crucial chemical reagent in the field of organic synthesis. It has a wide range of uses, most notably in pharmaceutical synthesis. In the preparation of many drugs, 2-thiophene acetyl chloride plays an indispensable role. For example, in the synthesis path of many antibiotics, 2-thiophene acetyl chloride needs to react with specific compounds to build a key molecular structure, thereby giving the drug key pharmacological activities such as antibacterial.
Furthermore, in the field of pesticide synthesis, 2-thiophene acetyl chloride also plays an important role. Pesticide products with specific insecticidal, bactericidal or herbicidal effects can be prepared by interacting with different organic compounds. By precisely adjusting the reaction conditions and the ratio of reactants, pesticide active ingredients with diverse structures can be synthesized to meet the diverse needs of pest control in agricultural production.
In addition, 2-thiophene acetyl chloride also plays a significant role in the synthesis of fine chemical products. Such as the synthesis of some dyes, fragrances and intermediates of polymer materials with special properties. Through clever use of its chemical activity, organic compounds with complex structures and unique functions can be constructed, providing rich raw materials and technical support for the development of the fine chemical industry. Overall, 2-thiophene acetyl chloride has irreplaceable uses in many important chemical and pharmaceutical fields due to its unique chemical properties, promoting the continuous progress and development of related industries.

The synthesis method of 2-thiophene acetyl chloride has existed in ancient times, and with the evolution of the world, the method has also become more and more abundant. Today, the number of methods is described in detail below.
One, based on 2-thiophene acetic acid, is prepared with a chlorination reagent. In the past, thionyl chloride was often used as a chlorination agent. The two are co-placed in a suitable device, adding a little catalyst, such as N, N-dimethylformamide. Gradually warm up to make the two react. Sulfuryl chloride and 2-thiophene acetic acid interact when heated, and the chlorine atom of thionyl chloride replaces the hydroxyl group of acetic acid, escaping sulfur dioxide and hydrogen chloride gas. This reaction is mild, the yield can also be observed, because the generated gas is easy to escape, and the post-treatment is simple.
Second, phosphorus trichloride can also be used as a chlorination reagent. Put 2-thiopheneacetic acid and phosphorus trichloride in a certain proportion into the reactor. This reaction does not require complicated conditions, and can be started at room temperature or slightly heated. The active chlorine of phosphorus trichloride is exchanged with the hydroxyl group of acetic acid to obtain 2-thiopheneacetyl chloride, and phosphoric acid is formed at the same time. Although this process has by-products of phosphoric acid, it is not difficult to separate, so it is also a common method.
Third, oxalyl chloride can also be chlorinated. 2-Thiophene acetic acid meets oxalyl chloride in a suitable solvent, such as dichloromethane, and chlorination occurs with the help of a catalyst. Oxalyl chloride has a special structure. During the reaction, its monocarbonyl group is converted into carbon dioxide and carbon monoxide escapes, and another chlorine atom and 2-thiophene acetic acid form 2-thiophene acetyl chloride. This reaction is clean and neat, and the by-products are all gases. The products are pure and popular.
All these numbers have their own advantages and disadvantages. In actual operation, when the availability of raw materials, cost considerations, availability of equipment and product requirements and other factors are carefully selected, the best effect can be obtained.

2-Thiophene acetyl chloride is an important raw material in organic synthesis. Its physical properties are unique and are described here.
Looking at its morphology, 2-thiophene acetyl chloride is often colorless to light yellow liquid at room temperature. Although its color is not bright, it plays an extraordinary role in the field of synthesis. It has a pungent smell and is uncomfortable to smell, which needs to be treated with caution.
When it comes to boiling point, it is about a specific temperature range, but the exact value varies depending on the environment and measurement method. The characteristics of boiling point have a great influence on operations such as separation and purification. Because it has a certain volatility, it should be paid attention to when using and storing to prevent escape.
As for the density, it also has its specific value. This physical property is related to its state when mixed with other substances, and is of great significance for the construction of chemical reaction systems. In many organic synthesis reactions, the density characteristics may affect the contact and reaction process of the reactants.
In terms of solubility, 2-thiophene acetyl chloride is soluble in common organic solvents, such as ether, dichloromethane, etc. This solubility makes it possible to be widely used in different reaction systems, enabling the reaction to proceed efficiently in homogeneous systems, which is conducive to the full occurrence of reactions and the generation of products. The physical properties of 2-thiophene acetyl chloride have far-reaching applications in organic synthesis, and users should be familiar with their properties in order to make good use of them to achieve the desired synthesis goals.

2-Thiophene acetyl chloride is an important raw material for organic synthesis. During storage and transportation, many matters need to be paid attention to.
First words storage. This material is lively, corrosive and irritating, and should be stored in a cool, dry and well-ventilated place. The temperature should be constant, avoiding high temperature and humidity. Due to high temperature, it can cause its volatilization to intensify, moisture or hydrolysis reaction, which will damage its quality. Storage must be kept away from fire and heat sources. Fireworks are strictly prohibited. Because of their flammability, they are at risk of open flame, hot topic or combustion explosion. And it needs to be stored separately from oxidants and alkalis, and must not be mixed with storage to prevent severe chemical reactions.
Then transport. When handling, be sure to pack and unload lightly, and beware of damage to the packaging container. The packaging should be firmly sealed to ensure that there is no risk of leakage during transportation. Transportation vehicles need to be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. During driving, it is necessary to prevent exposure to the sun, rain, and high temperature. Road transportation should be carried out according to the specified route, and do not stop in residential areas and densely populated areas. Transportation personnel also need to be professionally trained, familiar with its physical and chemical properties and emergency treatment methods, and strictly abide by the operating procedures during transportation.
In this way, when storing and transporting 2-thiophene acetyl chloride, everything should be cautious and strictly abide by the norms, so as to ensure safety, avoid danger, and avoid accidents.

What you are asking about is the market price range of 2-thiophene acetyl chloride. Sadly, we do not have real-time exact market price information. However, in the past, the price of such chemical materials often changed due to many factors.
Its price may be affected by the supply of raw materials. If the raw materials for preparing 2-thiophene acetyl chloride, such as thiophene and acetic acid, are abundant and stable, the cost of 2-thiophene acetyl chloride can be controlled, and the price may stabilize. On the contrary, if the raw materials are scarce and the price rises, it will also rise accordingly.
The production process and technical level are also key. Advanced production technology can improve production efficiency, reduce energy consumption and loss, and then reduce product costs, which has an advantage in market pricing. If the process is outdated and the cost is high, the price will not be cheap.
The amount of market demand also affects its price. If many industries, such as medicine, pesticides, etc., have strong demand for 2-thiophene acetyl chloride, the supply will exceed the demand, and the price will rise. If the demand is low and the supply exceeds the demand, the price will easily drop.
Regional differences cannot be ignored. Different places have different prices due to different transportation costs, local economic levels, and market competition. Prosperous places, high demand and convenient logistics, prices may be relatively reasonable due to competition; remote places, high transportation costs, inconvenient supply, or high prices.
To know the exact price range, it is recommended to consult chemical product suppliers, distributors, or consult professional chemical market information platforms to obtain accurate price information.