2-Hydroxymethylthiophene

2-Hydroxymethylthiophene is also an organic compound. It has a wide range of uses and is important in various fields of chemical industry.
First, in the field of drug synthesis, this compound is a key intermediary. Due to the unique electronic structure and biological activity of the thiophene ring, a variety of drugs can be created with 2-hydroxymethylthiophene as the starting material and chemically modified. For example, by the specific reaction of its hydroxymethyl and thiophene ring, a molecular structure with specific pharmacological activity can be constructed for the development of new antibacterial, anti-inflammatory and anti-tumor drugs.
Second, in the field of materials science, 2-hydroxymethylthiophene also has important value. It can be used as a monomer and polymerized to obtain polymer materials with special properties. Due to the unique electrical and optical properties of the thiophene structure, the obtained polymer may have good conductivity or fluorescence properties, which can be used to prepare organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices, paving the way for the development of new materials.
Third, in organic synthetic chemistry, 2-hydroxymethylthiophene is a multi-functional synthetic building block. Its hydroxymethyl groups can undergo reactions such as esterification and etherification, and thiophene rings can also undergo electrophilic substitution. Through these reactions, chemists can construct complex organic molecular structures, providing effective strategies and raw materials for the synthesis of natural products and fine chemicals.
In short, 2-hydroxymethylthiophene has shown great application potential in many fields such as drugs, materials and organic synthesis due to its unique chemical structure, promoting scientific research and technological development in related fields.

2-Hydroxymethylthiophene, its physical properties are as follows:
Viewed at room temperature, 2-hydroxymethylthiophene is mostly colorless to light yellow liquid, and its appearance is clear and transparent. Smell, it has a special smell, although it is difficult to describe accurately, it is slightly pungent.
Its boiling point is quite critical, about 200-210 ° C. This characteristic makes it possible to convert from liquid to gaseous under a specific temperature environment, which is convenient for separation and purification. Furthermore, the melting point is also an important property, about -10 ° C, which means that below this temperature, 2-hydroxymethylthiophene will solidify from liquid to solid. < Br >
The density of 2-hydroxymethylthiophene is about 1.18-1.22 g/cm ³ compared with water, which is slightly heavier than water. In terms of solubility, its solubility in water is limited, but it can be miscible with many organic solvents, such as ethanol, ether, acetone, etc., in any ratio. This solubility property provides a basis for the selection of suitable solvent systems when used in chemical synthesis and other fields.
Its refractive index is about 1.55-1.57, and this optical property is of great significance for identification and purity detection. By measuring the refractive index, its purity and quality can be preliminarily judged, providing a key reference for practical applications.
In summary, the physical properties of 2-hydroxymethylthiophene play an indispensable role in the application and research of many fields such as chemical industry and medicine.

2-Hydroxymethylthiophene is an important member of the family of organic compounds. In its molecular structure, there is a hydroxymethyl group attached to the second position of the thiophene ring, which endows it with many special chemical properties.
The first to bear the brunt is its nucleophilic substitution reaction characteristics. Because the hydroxyl group on the hydroxymethyl group has a certain nucleophilicity, when encountering suitable electrophilic reagents, such as halogenated hydrocarbons, the hydroxyl oxygen atom will attack the carbon atom of the halogenated hydrocarbon, and the halogen ion will leave, then the nucleophilic substitution reaction will occur to form ether derivatives. This reaction is often an important means to construct new carbon-oxygen bonds in organic synthesis.
Furthermore, 2-hydroxymethylthiophene can participate in the esterification reaction. Hydroxy groups can be esterified with carboxylic acids or their derivatives, such as acyl chloride, acid anhydride, etc., under catalytic conditions to form ester groups. In this process, the hydrogen atom of the hydroxyl group is combined with the hydroxyl group of the carboxylic acid to form water dehydration, and the resulting ester products are widely used in the fields of fragrance and drug synthesis.
From the perspective of oxidation reaction, hydroxymethyl groups can be oxidized. Mild oxidants, such as manganese dioxide, can oxidize hydroxymethyl groups to aldehyde groups to obtain 2-formylthiophene; if stronger oxidants are used, such as potassium permanganate, the aldehyde groups can be further oxidized to carboxylic groups to obtain 2-thiophenecarboxylic acid.
In addition, 2-hydroxymethylthiophene can undergo aromatic electrophilic substitution due to the aromatic properties of the thiophene ring. For example, under the action of a suitable catalyst, when reacting with bromine, bromine atoms will replace hydrogen atoms on the thiophene ring to form brominated derivatives. The selectivity of this reaction check point is often affected by the localization effect of hydroxymethyl groups. Because it is an ortho and para-localization group, bromine atoms are polysubstituted in the adjacent or opposite positions of the thiophene ring and the hydroxymethyl group.
In summary, 2-hydroxymethylthiophene is active in nucleophilic substitution, esterification, oxidation and aromatic electrophilic substitution due to its unique structure, and plays an indispensable role in the field of organic synthetic chemistry.

The synthesis method of 2-hydroxymethylthiophene is the most important in the field of organic synthesis. There are many methods, and each has its advantages and disadvantages, which are described in detail below.
First, the method of using thiophene-2-formaldehyde as the starting material. First, thiophene-2-formaldehyde is reacted with an appropriate reducing agent, such as sodium borohydride, in a suitable solvent, such as methanol. Sodium borohydride can reduce aldehyde groups to hydroxymethyl groups. This reaction condition is mild, easy to operate, and the yield is relatively considerable. During the reaction, control the temperature in a moderate range, such as 0-5 ° C, slowly add sodium borohydride, and stir for a number of times. After post-treatment, such as extraction, distillation and other steps, 2-hydroxymethylthiophene can be obtained.
Second, the method of using thiophene and formaldehyde as raw materials. In the presence of a specific catalyst, such as an acidic catalyst, thiophene and formaldehyde undergo an electrophilic substitution reaction. The reaction needs to be carried out under appropriate temperature and pressure conditions. For example, under the action of an acidic catalyst such as sulfuric acid, at a certain temperature range, such as 50-70 ° C, the reaction time can produce the target product. The raw materials of this method are easy to obtain, but the reaction selectivity needs to be carefully regulated, otherwise it is easy to produce side reactions and affect the purity of the product.
Third, through the method of halogenated thiophene derivatives. First prepare halogenated thiophenes, such as chlorothiophene or bromothiophene, and then react with formaldehyde and bases, such as sodium hydroxide, in appropriate solvents. The halogen atom is replaced by hydroxymethyl to generate 2-hydroxymethylthiophene. In this process, the conditions for the preparation of halogenated thiophene and subsequent substitution reactions are very critical, such as the reaction temperature, the amount of base, etc., which will affect the reaction process and product yield.
All synthesis methods have their own unique characteristics. In practical application, it is necessary to choose carefully according to specific needs, such as raw material availability, cost considerations, product purity requirements, etc.

I look at your question, but I am inquiring about the price range of 2-hydroxymethylthiophene in the market. However, the market situation is changeable, and the price varies from time to time, as well as due to various factors such as quality, quantity, and source.
In the past, the price of this substance often fluctuated. If the quantity is small, buy it from the supplier, small packaging (such as hundreds of grams), the price per gram may be more than tens to hundreds of yuan, depending on the purity. Those with high purity will also have high prices.
If the demand is large, buy in bulk in kilograms, and the price per kilogram may be reduced to several thousand yuan. However, the market for chemical raw materials is changing, and the cost of raw materials, the trend of supply and demand, and policies and regulations can all change.
To know the exact price, you can visit the chemical product trading platform, such as Gade Chemical Network, etc., which often lists prices on the merchant, which can be used as a reference. Or consult the supplier of chemical raw materials, ask the price directly, and get the exact number according to the quantity and quality you need.
Furthermore, in inter-market transactions, bargaining is also common, and when the quantity is large, you may get a preferential price. Therefore, in order to obtain the real price of 2-hydroxymethylthiophene, it is necessary to inquire and compare in many ways in the current market conditions.