2 Formylthiophene 4 Boronic Acid
quinoline thiophene imidazole thiazole

2-Formylthiophene-4-boronic acid

Taiy Chemical

    Specifications

    HS Code

    103992

    Chemical Formula C5H5BO3S
    Molar Mass 154.97 g/mol
    Appearance Solid (usually white to off - white)
    Melting Point 125 - 130 °C (approximate, may vary by source)
    Solubility In Water Low solubility, sparingly soluble
    Solubility In Organic Solvents Soluble in some polar organic solvents like DMSO, THF
    Boiling Point Decomposes before boiling under normal conditions
    Reactivity Reactive towards electrophiles, can participate in Suzuki - Miyaura coupling reactions

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    General Information
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    Frequently Asked Questions

    As a leading 2-Formylthiophene-4-boronic acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-formylthiophene-4-boronic acid?
    2-% methyl benzyl ether-4-sulfonic acid has a wide range of main uses. This compound is often used as a key intermediate in the field of organic synthesis.
    In the field of organic synthesis, 2-methyl benzyl ether-4-sulfonic acid can be used to construct various complex organic molecular structures. Because of its unique chemical activity and structural characteristics, it can interact with other organic reagents through various chemical reactions, such as nucleophilic substitution, esterification, condensation, etc., to derive multiple organic compounds, which play an important role in the fields of pharmaceutical chemistry and materials science. < Br >
    In pharmaceutical chemistry, it can be used as a starting material or an important intermediate to help create new drugs. In the synthesis path of many drug molecules, 2-methyl benzyl ether-4-sulfonic acid can precisely introduce specific functional groups due to its special structure to meet the requirements of drug molecules for activity, selectivity and pharmacokinetic properties, laying the foundation for the development of new drugs.
    As for the field of materials science, this compound is also useful. It can be integrated into the structure of polymer materials through specific reactions, giving materials such as special solubility, thermal stability, and optical properties. For example, in the preparation of some functional polymer materials, the introduction of 2-methylbenzyl ether-4-sulfonic acid structural units can effectively regulate the electrical properties of the materials, making them suitable for specific fields such as organic semiconductor materials.
    In addition, in the production of fine chemical products, 2-methylbenzyl ether-4-sulfonic acid is also often used as a raw material or additive to optimize product performance, improve product quality and added value, and play an indispensable role in the manufacturing of fine chemicals such as dyes, fragrances, and additives.
    What are the synthesis methods of 2-formylthiophene-4-boronic acid?
    To prepare 2-methylpropene-4-sulfonic acid, the method is as follows:
    First, sulfonate with isobutylene and fuming sulfuric acid. The isobutylene is slowly introduced into the reactor containing fuming sulfuric acid, and the two can be sulfonated under low temperature and stirring state. The reaction temperature and the ratio of raw materials need to be carefully controlled. If the temperature is too high, there will be many side reactions, and improper ratio will also affect the yield. The principle of this reaction is that the double bond of isobutylene is electrophilic, and the sulfate ion in the fuming sulfuric acid attacks the double bond electrophilically, and then generates the target product. However, in this process, due to the strong corrosiveness of fuming sulfuric acid, the operation must be extremely cautious, and the post-reaction treatment is complicated, and the product separation and purification
    Second, methacrylate is used as the starting material, first halogenated, and then reacted with sulfite. First, methacrylate and halogenating agent (such as bromine) are subjected to free radical halogenation reaction in a suitable solvent under the action of light or initiator to obtain halogenated methacrylate. Then, this halogen is reacted with sulfite (such as sodium sulfite) in aqueous solution, and the halogen atom is replaced by sulfonic acid to obtain 2-methylpropene-4-sulfonic acid. This route has a little more steps, but the reaction conditions of each step are relatively mild, the equipment requirements are not as high as fuming sulfuric acid sulfonation, and the raw materials are relatively easy to obtain. However, the amount of halogenating agent and the degree of reaction in the halogenation process need to be precisely controlled, otherwise it will affect the subsequent reaction and the purity of the product.
    Third, you can try to use acaldehyde as raw material and prepare it through a series of reactions such as methylation and sulfonation. First, the methylation reaction between acaldehyde and the methylating reagent is carried out, and methyl is introduced. Then the obtained product is sulfonated to obtain the target product. This path design is novel, but acaldehyde is toxic and volatile, and the operating environment needs to be strictly controlled. And the selectivity and conversion rate of each step of the reaction need to be further studied and optimized to improve the overall preparation efficiency and product quality.
    What are the physical properties of 2-formylthiophene-4-boronic acid?
    2-% methyl benzyl ether-4-sulfonic acid is one of the organic compounds. Its physical properties are as follows:
    Looking at its properties, at room temperature, it is mostly a crystalline solid state, white and pure, like snow falling at the beginning of winter, delicate and homogeneous, or has a faint luster under light. Its melting point is quite critical, about a specific temperature range. This melting point makes the substance change in state at the corresponding temperature environment, gradually melting from solid to liquid, such as ice disappearing under warm sunlight.
    As for solubility, 2-methylbenzyl ether-4-sulfonic acid can exhibit a certain solubility in water, just like fine sand fused into clear flow, and some can merge with water molecules and disperse into them to form a uniform system. However, in organic solvents, such as ethanol and acetone, its solubility may be better, just like fish getting water, and it is easier to disperse evenly. This solubility property is of crucial significance in many chemical processes, such as separation, purification, and choice of reaction medium.
    When it comes to density, this substance also has its specific value. This density makes it occupy a corresponding space with a certain weight. During actual operation and storage, it is related to the selection of containers and the measurement of materials. If the density is not well grasped, it may cause many inconveniences, such as too much or too little material filling, which will affect the accuracy of subsequent processes.
    In addition, its smell is weak and special. Although it is not pungent or unpleasant, it is also unique. In the field of fine chemicals, this unique smell may help to identify, or it needs to be considered in the manufacture of some products with strict requirements for smell. These physical properties are related to each other and together outline the physical characteristics of 2-methylbenzyl ether-4-sulfonic acid, which lays the foundation for its application in the chemical industry and related fields.
    Is the chemical properties of 2-formylthiophene-4-boronic acid stable?
    The chemical properties of 2-% methylpropenyl ether-4-sulfonic acid are quite stable. This substance has a unique structure, and the sulfonic acid group has a certain stability. In the sulfonic acid group, the chemical bonds formed by sulfur atoms and multiple oxygen atoms are relatively firm, making the whole group less prone to fracture. At the same time, although the carbon-carbon double bond of the 2-methylpropenyl ether part has certain reactivity, due to the steric resistance and electronic effect of the surrounding groups, its stability is also affected.
    From the perspective of common chemical reactions, under generally mild conditions, 2-% methylpropenyl ether-4-sulfonic acid is not easy to decompose by itself or react violently. For example, in a normal acid-base environment, as long as the acid-base concentration is not too high and the reaction temperature is not too extreme, its structure can remain relatively stable.
    However, it should be noted that in the case of strong oxidizing agents or specific catalysts, and the reaction conditions are more severe, its structure may change. Strong oxidizing agents may attack sulfonic acid groups or carbon-carbon double bonds, resulting in oxidation reactions. However, in normal storage and conventional use scenarios, as long as contact with these special chemicals is avoided, 2-% methylpropenyl ether-4-sulfonic acid can maintain good stability, which can meet the chemical stability requirements of many practical applications.
    What are the precautions for 2-formylthiophene-4-boronic acid in storage and transportation?
    When storing and transporting 2-% methyl-3-nitropyridine-4-sulfonic acid, there are many key points to be paid attention to.
    First, when storing, it should be found in a cool, dry and well-ventilated place. This compound is quite sensitive to humidity, and humid environments can easily cause it to deteriorate, which in turn affects quality and performance. Therefore, it is necessary to ensure that the storage place is free from moisture worries, and a desiccant can be properly placed to maintain dryness. Temperature also needs to be strictly controlled. Excessive temperature may cause its chemical reaction, resulting in decomposition or other adverse changes. Generally speaking, it is recommended to store in a lower temperature environment and avoid direct sunlight, because light may also induce certain photochemical reactions and damage its chemical stability.
    Second, during transportation, the packaging must be solid and reliable. This substance has a certain chemical activity. If the packaging is not good, the vibration, collision, etc. during transportation may cause the packaging to be damaged, and then leak, which may not only pollute the environment, but also endanger the safety of transporters. The packaging material should have good corrosion resistance to resist the possible corrosive effects of the compound. At the same time, the transportation vehicle needs to maintain suitable temperature and humidity conditions to avoid severe turbulence and sudden temperature changes. Transport personnel should also be familiar with the characteristics of the compound and emergency treatment methods. In the event of an accident, they can respond quickly and properly.
    In addition, whether it is storage or transportation, relevant regulations and standards must be strictly followed. This compound or category of hazardous chemicals must be implemented in accordance with the regulations on the management of hazardous chemicals, from storage conditions to transportation labels, in order to ensure the safety and compliance of the entire process and prevent irreparable damage to people and the environment.