2-Cyano-5-Bromothiophene

2-Cyano-5-bromothiophene is a crucial intermediate in the field of organic synthesis. It has a wide range of uses and plays a key role in many chemical synthesis pathways.
The primary use lies in the field of medicinal chemistry. This compound can be used as a key structural unit to construct drug molecules with specific biological activities through a series of chemical reactions. By modifying and derivatizing its structure, various types of drugs such as antibacterial, anti-inflammatory, and anti-tumor can be prepared. For example, by ingeniously designing reaction steps, researchers have successfully developed novel drug lead compounds that have significant inhibitory effects on specific tumor cells by combining 2-cyano-5-bromothiophene with other compounds containing functional groups such as nitrogen and oxygen.
Furthermore, it also has important applications in the field of materials science. Due to its unique electronic structure and chemical properties, it can be used to synthesize materials with special photoelectric properties. For example, when preparing organic Light Emitting Diode (OLED) materials, 2-cyano-5-bromothiophene can be used as the core structure part to optimize the luminous efficiency and stability of the material. After appropriate chemical modification, the materials synthesized on this basis can emit light of a specific wavelength, which shows potential application value in display technology.
In addition, in the field of pesticide chemistry, 2-cyano-5-bromothiophene is also useful. It can be used to synthesize pesticide products with high insecticidal and bactericidal activities. Through rational molecular design and reaction optimization, it can be integrated with other pesticide active groups to develop new pesticides with good control effect on crop diseases and pests and environmental friendliness. In conclusion, 2-cyano-5-bromothiophene, with its unique chemical structure, plays an indispensable role in many fields such as drugs, materials, and pesticides, providing an important material basis and research direction for the development of related fields.

2-Cyano-5-bromothiophene is an organic compound with special physical and chemical properties, which is very important in the field of organic synthesis. Its physical properties are as follows:
In terms of view, 2-cyano-5-bromothiophene is usually in a solid state, which is easy to store and operate. Its color may be white to light yellow, and this color characteristic can help to distinguish.
It is related to the melting point, which has been experimentally determined to be in a specific temperature range. Melting point is an important physical property of a substance, which is of great significance for the study of its purity and phase transformation. Knowing the melting point accurately allows the reaction conditions to be controlled during synthesis to ensure the quality of the product.
In terms of solubility, 2-cyano-5-bromothiophene exhibits a certain solubility in common organic solvents, such as dichloromethane and chloroform. This property makes it effective in dissolving in the reaction system in organic synthesis reactions, fully contacting with other reactants, and promoting the reaction. However, in water, its solubility is poor, which is caused by the difference between the structure of the compound and the polarity of water.
In addition, 2-cyano-5-bromothiophene has a certain stability. Under conventional conditions, it can maintain its own structure and properties. However, under specific conditions, such as high temperature, strong acid and alkali environment, its structure may change, resulting in changes in chemical properties. This stability feature requires careful consideration when storing and using it, and it should be avoided in an inappropriate environment to prevent deterioration or dangerous reactions.

The synthesis method of 2-cyano-5-bromothiophene has been explored by many scholars in the past, and the methods are various, and now the common ones are described.
First, thiophene is used as the starting material, and it is obtained by bromination and cyanidation in two steps. First dissolve thiophene in a suitable organic solvent, such as dichloromethane, and slowly drop bromine at low temperature. Pay attention to the control of the reaction temperature, so as not to cause side reactions to breed if it is too high. After the bromination reaction is completed, 5-bromothiophene is separated and purified. Next, 5-bromothiophene is reacted with cyanide reagents, such as cuprous cyanide, in suitable solvents and reaction conditions. In this cyanidation step, heating, catalysis and other means are required to promote the reaction, and finally 2-cyano-5-bromothiophene is obtained.
Second, using 5-bromo-2-thiophenecarboxylic acid as raw material, it is first converted into the corresponding acid chloride, and thionyl chloride is commonly used to react with it. After obtaining the acid chloride, it is then reacted with the cyanide reagent, such as sodium cyanide, in a suitable solvent, and through a series of transformations, the target product can be obtained. In this path, the reaction conditions at each step, such as temperature, time, and reagent dosage, need to be carefully adjusted to achieve higher yield and purity.
Third, 2-cyano-5-bromothiophene is also synthesized from other compounds containing thiophene structures through multi-step functional group transformation. However, such methods may be inconvenient in practical application due to the difficulty of raw materials or the complicated reaction steps.
In short, the synthesis of 2-cyano-5-bromothiophene has its own advantages and disadvantages, depending on the specific situation, such as the availability of raw materials, the ease of control of reaction conditions, and cost considerations.

2-Cyano-5-bromothiophene is on the market, and its price range is difficult to determine. The price of the cap often varies due to many reasons, such as the source of the material, the difficulty of preparation, the amount of demand, and the ups and downs of the market conditions.
In the past, if the material was easy to obtain, the preparation method was simple, and there were not many applicants, the price was slightly cheaper. However, if the material is rare, the preparation requires a complicated process, and the buyer is slow, the price must be high.
According to past examples, when the material is abundant, the preparation is smooth, and the market is stable, the price may be in the tens of yuan per gram. If the materials are scarce, the preparation is very difficult, and the market demand increases greatly, the price may rise to hundreds of yuan per gram, or even higher.
In addition, the price can also be different depending on the region. Near the origin of the material, or where the preparation is convenient, the price may be relatively easy; in remote places, the transportation is difficult, and the tax and other items, the price may be high.
Furthermore, with the passage of time and the advancement of science and technology, if a new and better preparation method is developed, the cost may be greatly reduced, and the price may also drop accordingly; on the contrary, if the price of raw materials rises, or the policy changes, the preparation is limited, and the price may rise. Therefore, if you want to know the exact price range, you need to constantly observe the market conditions and consult the supplier before you can obtain it.

2-Cyano-5-bromothiophene is an organic compound. The storage conditions are quite important, which is related to the stability and quality of this substance.
Cover 2-cyano-5-bromothiophene should be stored in a cool, dry and well-ventilated place. In a cool place, the temperature should not be too high. If it is too high, it is easy to cause chemical reactions in the compound, which will damage its inherent properties. Generally speaking, the storage temperature should be controlled between 15 ° C and 25 ° C. This temperature range can ensure that its chemical properties are relatively stable and less abnormal.
Dry environment is also indispensable. Due to the exposure of 2-cyano-5-bromothiophene to water or moisture, it is afraid of adverse reactions such as hydrolysis, resulting in a decrease in its purity and impaired effectiveness. Therefore, the storage place must be protected from moisture, and the air humidity should be maintained between 40% and 60%.
Furthermore, good ventilation is essential. If the storage space is poorly ventilated, the gas emitted by the compound may accumulate, one may cause an unpleasant smell, and the other may pose a safety risk, such as an open flame or an explosion.
And this substance should be stored separately from oxidants, acids, alkalis and other substances, and must not be mixed. Edge oxidants have strong oxidizing properties, or react violently with 2-cyano-5-bromothiophene; acids and bases are chemically active and can also react chemically with the compound, endangering safety and quality.
Storage containers also need to be carefully selected. A well-sealed container should be used to prevent the intrusion of air, moisture, etc. Common glass containers or plastic containers can be used if they have good sealing performance. However, it should be noted that some plastic materials may react with compounds, so compatibility tests should be done before use.
In short, when storing 2-cyano-5-bromothiophene, be sure to pay attention to temperature, humidity, ventilation, and isolation from other substances, and choose a suitable storage container to ensure its quality and safety.