2-Chloro-5-(trifluoromethyl)thiophene

2-Chloro-5- (trifluoromethyl) thiophene is a class of organic compounds. It has a wide range of uses and is of great value in many fields.
First, in the field of medicinal chemistry, this compound is often used as a key intermediate. During the development of medicine, by modifying and transforming its structure, a variety of drug molecules with specific biological activities can be prepared. Due to its unique chemical structure, it can interact with specific targets in organisms, thus contributing to the development of new drugs, such as antibacterial, antiviral, and anti-tumor drugs, which have made great contributions to human health.
Second, in the field of materials science, 2-chloro-5- (trifluoromethyl) thiophene also plays an important role. It can be used to synthesize polymer materials with special properties, and its introduction can significantly improve the electrical, optical and thermal properties of the materials. For example, it is used in the preparation of organic semiconductor materials. Such materials are widely used in devices such as organic Light Emitting Diode (OLED) and organic field effect transistor (OFET), which greatly promotes the development of display technology and electronic devices.
Third, in pesticide chemistry, this compound can be used as an important raw material for the synthesis of efficient pesticides. With its mechanism of action against specific pests or pathogens, through rational design and synthesis, high-efficiency, low-toxicity and environmentally friendly pesticide products can be developed, which helps to improve crop yield and reduce environmental harm.
In summary, 2-chloro-5- (trifluoromethyl) thiophene is an indispensable and important substance in many fields such as medicine, materials, and pesticides due to its unique chemical structure and properties, and has far-reaching significance for the development of modern science and technology and industry and agriculture.

2-Chloro-5- (trifluoromethyl) thiophene is also an organic compound. It has many physical properties, which are described in detail today.
First of all, under normal temperature and pressure, 2-chloro-5- (trifluoromethyl) thiophene is a colorless to light yellow liquid. It is clear and transparent, like the clarity of a spring. Its smell has a special smell. Although it is not pungent and unpleasant, it is also different from common odorless or aromatic things. This unique smell can be used as one of the identification aids.
When it comes to the melting point, the melting point of this compound is quite low, about -39 ° C. Like winter ice, it melts with a little warmth. This property makes 2-chloro-5- (trifluoromethyl) thiophene still liquid at lower temperatures and has good fluidity.
Boiling point, about 146-147 ° C. When heated to this point, the liquid boils and converts to a gaseous state. This boiling point is in the moderate range among organic compounds, which is more volatile than those with high boiling points, and relatively stable than those with low boiling points.
In terms of density, about 1.45g/cm ³. This value indicates that its density is heavier than that of water. If it is co-placed with water in a container, 2-chloro-5- (trifluoromethyl) thiophene will sink to the bottom of the water, like a stone falling into the abyss.
Solubility is also an important property. It is slightly soluble in water, but it can be soluble in many organic solvents, such as ether, ethanol, acetone, etc. Just like fish in water, it can be easily dispersed in organic solvents, and this solubility provides convenience for its application in organic synthesis and other fields. The physical properties of 2-chloro-5- (trifluoromethyl) thiophene are unique and interrelated, which affect its state and application in different environments. It is of great significance in the research and practice of organic chemistry.

2-Chloro-5- (trifluoromethyl) thiophene, the chemical properties of this substance are relatively stable. In its molecular structure, the thiophene ring is inherently stable, and the presence of chlorine atoms and trifluoromethyl groups has a slight impact on its chemical activity, but it is not prone to change.
The thiophene ring is aromatic and consists of a conjugated π electronic system. This structure gives it a certain degree of stability, making it resistant to chemical reactions under normal conditions. Although the chlorine atom is electron-absorbing, it can reduce the density of the electron cloud on the ring and enhance the activity of electrophilic substitution. However, this effect is not extremely significant and does not cause the molecular structure to disintegrate instantaneously.
Furthermore, trifluoromethyl is a strong electron-absorbing group, which also affects the electron cloud distribution of the thiophene ring, which can increase the polarity of the molecule, but also stabilize the entire molecular structure to a certain extent. Due to its strong electron absorption, it can attract surrounding electron clouds, which makes the distribution of electron clouds within the molecule more reasonable, and reduces the instability caused by uneven distribution of electron clouds.
Under common chemical reaction conditions, if there is no specific reagent or strong reaction conditions, such as high temperature, high pressure, strong acid-base or specific catalyst, the chemical properties of 2-chloro-5- (trifluoromethyl) thiophene can be maintained relatively stable. For example, when there are no special reactants at room temperature and pressure, it can stand in the air for a certain period of time without obvious chemical changes. However, in some special chemical reaction environments, such as under the action of specific nucleophiles or strong oxidants, its chemical stability will be challenged, and the molecular structure may undergo corresponding transformation.

The synthesis methods of 2-chloro-5- (trifluoromethyl) thiophene have existed in ancient times, and there are many kinds. The following are briefly described.
First, thiophene is used as the starting material, and chlorine atoms are introduced into a specific position of the thiophene ring through a halogenation reaction. This halogenation reaction, or chlorine gas, chlorination agent, etc., under suitable reaction conditions, makes chlorine atoms replace hydrogen atoms on the thiophene ring to obtain chlorine-containing thiophene derivatives. Then, through specific nucleophilic substitution or other conversion steps, trifluoromethyl groups are introduced. A reagent containing trifluoromethyl can be selected to achieve the substitution of trifluoromethyl to the corresponding position on the thiophene ring in a suitable catalyst and reaction environment, and finally obtain 2-chloro-5- (trifluoromethyl) thiophene.
Second, starting from the construction of thiophene ring. The target product can be directly synthesized through cyclization reaction using chlorine-containing and trifluoromethyl-containing raw materials. For example, with appropriate sulfur-containing compounds, halogenated hydrocarbons and trifluoromethylation reagents, under basic conditions or under the action of a specific catalyst, the intramolecular cyclization is promoted through a multi-step reaction, and the chlorine atom and trifluoromethyl are introduced at the target position of the thiophene ring. This method requires precise control of the reaction conditions to ensure the smooth progress of the cyclization reaction and the accuracy of the substituent position.
Third, the coupling reaction is catalyzed by transition metals. First, chlorine-containing thiophene derivatives and trifluoromethyl-containing organometallic reagents or other suitable substrates are prepared. Subsequently, under the catalysis of transition metal catalysts such as palladium and nickel, the two are coupled to react, so that the chlorine atom and trifluoromethyl are connected to the thiophene ring to generate 2-chloro-5- (trifluoromethyl) thiophene. The key to this method is to select suitable catalysts, ligands and reaction solvents to improve the reaction activity and selectivity.

I don't know the price range of 2-chloro-5- (trifluoromethyl) thiophene in the market. The price of this compound often varies due to many factors.
First, its purity is the key factor. If the purity is extremely high, it is suitable for high-end scientific research experiments, and the price must be high; if the purity is slightly lower, it is used in general industrial synthesis, and the price may be slightly reduced.
Second, market supply and demand also have an impact. If there is a lot of demand and supply is scarce, the price will rise; if the supply is abundant and the demand is flat, the price may stabilize or even decline.
Third, the production process and cost are also related to the price. If the preparation process is complicated, special raw materials and equipment are required, the cost is high, and the price is also high; if the process is simple, the cost is controllable, and the price is close to the people.
Fourth, the purchase volume is also considered. Large purchases, suppliers may give discounts due to economies of scale, and the unit price is reduced; small purchases, the unit price may be relatively high.
In addition, different suppliers have different pricing strategies, which will also lead to price differences. Therefore, to know the exact price range, it is advisable to consult chemical raw material suppliers and chemical product trading platforms, and carefully observe market dynamics in order to obtain a more accurate price range.