2-Chloro-5-bromothiophene

2-Chloro-5-bromothiophene is one of the organic compounds. Its physical properties are quite critical and related to all things chemical.
In terms of its appearance, under room temperature, it is often colorless to light yellow liquid. This color state is clearly distinguishable, which is the first sign of identifying this substance. Looking at its color, light yellow and clear, reflected in the sun, you can see the brilliance of its circulation, like a clear spring, but it hides the mystery of chemical industry.
As for the melting point, it is between -13 ° C and -11 ° C. Although the value is small, it has a huge impact on chemical operation. The temperature is slightly different, or the state of this substance changes, which is related to the safety and smoothness of the subsequent process.
The boiling point is about 197 ° C to 199 ° C. At this temperature range, 2-chloro-5-bromothiophene begins to gradually change from liquid to gaseous state, and its molecules are active and break free from the bundle of the liquid phase. This boiling point value is the basis for separation and purification such as distillation.
Its density is about 1.78 g/cm ³, which is slightly higher than that of water. If placed in water, this substance enters the water like a sediment and settles slowly. Its weight is different from that of light substances on water.
In terms of solubility, 2-chloro-5-bromothiophene is soluble and easily melted in organic solvents, such as ethanol and ether. It is like snow entering a warm soup and quietly dissolves in it. However, in water, it is difficult to dissolve and does not dissolve, and the repulsion of water and oil is also apparent here.
In terms of volatility, although it is not very volatile, it gradually seems to evaporate in open places at room temperature. Molecules escape in the air, causing their odor to be audible and have a special fragrance. Although it is not rich, it is also one of the signs in the chemical environment.
These physical properties are the cornerstones of chemical synthesis, separation, and storage. It is of great significance to understand its nature and make good use of it in the rise of the chemical industry.

2-Chloro-5-bromothiophene is one of the organic compounds. It has unique chemical properties and is very important in the field of organic synthesis.
First of all, the chlorine and bromine atoms in 2-chloro-5-bromothiophene are both halogen atoms, so they have the properties of halogenated hydrocarbons. Halogen atoms are highly active and can participate in many nucleophilic substitution reactions. Under appropriate conditions, nucleophilic reagents such as alkoxides and amines can attack the carbon atoms connected to the halogen atoms, and the halogen atoms leave to form new compounds. For example, when alkoxides are used as nucleophiles, nucleophilic substitution can occur to obtain corresponding ether compounds; if amine nucleophiles are used, nitrogen-containing derivatives can be formed.
Furthermore, the thiophene ring itself also affects its chemical properties. Thiophene rings are aromatic and can participate in aromatic electrophilic substitution reactions. Since chlorine and bromine are electron-withdrawing groups, the electron cloud density of the thiophene ring will decrease, making the electrophilic substitution reaction slightly more difficult to occur than the thiophene itself. However, under suitable conditions and suitable electrophilic reagents, substitution can still occur on the thiophene ring. Electrophilic reagents usually attack the position with relatively high electron cloud density on the thiophene ring, such as the 3-position or 4-position of the thiophene ring.
In addition, 2-chloro-5-bromothiophene can still participate in metal-catalyzed reactions. Such as palladium-catalyzed cross-coupling reaction, this reaction can couple 2-chloro-5-bromothiophene with other organic halides or olefins to form carbon-carbon bonds, and then synthesize organic compounds with more complex structures, which are widely used in drug synthesis, materials science and other fields. 2-Chloro-5-bromothiophene plays an important role in the field of organic synthesis due to its rich and diverse chemical properties of halogen atoms and thiophene rings, providing key starting materials and reaction intermediates for the preparation of many organic compounds.

The common synthesis methods of 2-chloro-5-bromothiophene include the following.
First, thiophene is used as the starting material. The thiophene is first halogenated. This halogenation method usually uses liquid bromine and appropriate catalysts, such as iron powder, to introduce bromine atoms into thiophene at its 5th position under specific reaction conditions to obtain 5-bromothiophene. Then, 5-bromothiophene is chlorinated. For this chlorination reaction, a suitable chlorination reagent, such as N-chlorosuccinimide (NCS), can be selected. Under appropriate solvent and reaction conditions, chlorine atoms are introduced at the second position of 5-bromothiophene to obtain 2-chloro-5-bromothiophene.
Second, a strategy for constructing thiophene rings with sulfur-containing compounds and halogenated reagents. For example, under appropriate reaction conditions, 1,4-dihalo-2-butyne compounds and sulfides are cyclized to form thiophene rings. In the reaction process, by cleverly selecting the type of halogenated reagents and controlling the reaction conditions, halogen atoms are introduced at the 2nd and 5th positions of the thiophene ring, respectively, to achieve the purpose of synthesizing 2-chloro-5-bromothiophene. This strategy requires fine regulation of the reaction conditions in order to make the reaction proceed according to the expected path.
Third, with the help of metal-catalyzed coupling reactions. Thiophene derivatives with specific substituents can be prepared first, and then metal catalysts, such as palladium catalysts, can be used to catalyze the coupling reaction between halogenated aromatics and thiophene derivatives. 2-Chloro-5-bromothiophene is synthesized by precisely selecting halogenated aromatics, connecting chlorine atoms and bromine atoms to thiophene rings at suitable positions. This method is crucial to the choice of reaction conditions and catalysts, and requires careful preparation to obtain the ideal product.
The above synthetic methods have their own advantages and disadvantages. In actual synthesis, it is necessary to choose carefully according to specific conditions, such as the availability of raw materials, the difficulty of reaction, and the purity requirements of the product.

2-Chloro-5-bromothiophene is an important member of organic compounds. In the field of organic synthesis, its application is quite extensive.
The presence of chlorine and bromine atoms gives it special reactivity due to its unique structure. In pharmaceutical chemistry, using this as a starting material, chemists can introduce specific functional groups through various chemical reactions, such as nucleophilic substitution reactions, to construct drug molecular structures with specific biological activities, thereby facilitating the development of new drugs.
In the field of materials science, 2-chloro-5-bromothiophene also plays an important role. Polymer materials with special photoelectric properties can be prepared through polymerization. Such materials show potential application value in organic Light Emitting Diodes (OLEDs), organic solar cells and other fields, or can improve the performance and efficiency of devices.
Furthermore, in the fine chemical industry, this compound can be used to synthesize high-value-added fine chemicals. For example, through a series of chemical transformations, it can be prepared as a key intermediate for special coatings, fragrance additives and other products, thereby improving the quality and characteristics of products.
In short, 2-chloro-5-bromothiophene has important applications in many fields such as pharmaceutical chemistry, materials science, and fine chemicals due to its unique chemical properties, providing a key material foundation and technical support for the development of many industries.

The market price of 2-chloro-5-bromothiophene is difficult to determine directly. Its price often changes due to various reasons and is intricate.
First, the price of raw materials is of great significance. If the price of raw materials used in the synthesis of 2-chloro-5-bromothiophene fluctuates, the price of 2-chloro-5-bromothiophene will also be implicated. If the supply of raw materials is in short supply, or the output changes due to natural or geographical events, the price will rise; conversely, if the raw materials are abundant, the price may stabilize or even decline.
Second, the method of preparation also has an impact. Different production methods have different costs. If you use a subtle and efficient method, the cost may be reduced, and the price may also be reduced; however, if the preparation process is complicated and consumes a lot of resources, the cost will be high, and the market price will be high.
Third, the supply and demand of the market is the key. If the market demand for 2-chloro-5-bromothiophene is strong, but the supply is limited, if many chemical industries urgently need this material as a raw material, the demand will exceed the supply, and the price will rise; if the market demand is low, but the supply is sufficient, the manufacturer may sell its goods at a reduced price.
Fourth, the price varies from manufacturer to manufacturer. Each manufacturer sets the price differently due to differences in their own scale, operating costs, and marketing strategies. Large manufacturers may have advantages due to cost control due to economies of scale; small manufacturers may have relatively high prices due to higher costs.
Furthermore, the price varies from region to region. Different places have different selling prices due to different transportation costs, tax policies, and market competition. Located in remote and inconvenient places, the cost increases, and the price may be higher; in economically developed and highly competitive places, the price may be more reasonable.
To sum up, in order to know the exact market price of 2-chloro-5-bromothiophene, it is necessary to carefully consider the raw material price, preparation process, market supply and demand, manufacturer status and regional factors, etc., and comprehensively consider, in order to obtain a more accurate price.