2-Chloro-3-Methoxythiophene-4-Carboxylic acid

2-Chloro-3-methoxythiophene-4-carboxylic acid, this substance is an organic compound with unique physical properties. Its properties are mostly solid and stable at room temperature. Looking at its melting point, due to the interaction of chlorine atoms, methoxy groups and carboxyl groups in the molecular structure, the intermolecular force is unique, and the melting point is about [X] ° C.
In terms of solubility, in organic solvents such as dichloromethane, N, N-dimethylformamide, because the molecule contains polar groups carboxyl groups and methoxy groups, it can form intermolecular forces with organic solvents, showing good solubility; in water, although carboxyl groups can form hydrogen bonds with water, the hydrophobicity of thiophene rings and chlorine atoms limits their overall water solubility and is only slightly soluble.
Its density is also affected by the molecular structure. Due to the large relative atomic weight of chlorine atoms, the molecular weight is increased, and the density is higher than that of general hydrocarbon derivatives, about [X] g/cm ³.
Furthermore, this substance has a certain volatility. Although it is not very volatile due to intermolecular forces, under certain conditions such as heating or high vacuum, some molecules obtain enough energy to escape from the surface and exhibit a certain volatility. Its vapor pressure is about [X] kPa at [specific temperature]. The physical properties of 2-chloro-3-methoxythiophene-4-carboxylic acid are due to its unique molecular structure, and the interaction of each group results in its melting point, solubility, density and volatility.

2-Chloro-3-methoxythiophene-4-carboxylic acid, this substance has a wide range of uses and is often a key raw material for the creation of new drugs in the field of medicinal chemistry. Due to its unique chemical structure, it can interact with specific targets in organisms, or it can help the development of new drugs with unique curative effects, which may be beneficial to the treatment of difficult diseases.
In the field of materials science, it also has its uses. Or it can be chemically modified and polymerized to prepare functional materials with special properties, such as for optoelectronic devices, so that they have unique optical and electrical properties and improve the application efficiency of materials in this field.
In the field of organic synthesis, 2-chloro-3-methoxythiophene-4-carboxylic acid, as an important intermediate, can participate in the construction of many complex organic compounds. Through various organic reactions, such as esterification, amidation, etc., compounds with diverse structures are derived, which contribute to the development of organic synthetic chemistry and promote scientific research progress and technological innovation in related fields.

There are several common methods for the synthesis of 2-chloro-3-methoxythiophene-4-carboxylic acid.
First, the compound containing the thiophene structure is used as the starting material. First, the specific position of the thiophene ring is methoxylated, which can be achieved by a suitable nucleophilic substitution reaction. For example, a suitable halogenated thiophene is selected, and in the presence of a base, it reacts with a nucleophilic agent such as sodium methoxide to replace the halogen atom with a methoxy group. Then, chlorine atoms are introduced at another position, and a suitable halogenating agent, such as N-chlorosuccinimide (NCS), can be selected by halogenation reaction. Under specific reaction conditions, the chlorine atom can be substituted at the designated position of the thiophene ring. Finally, through carboxylation reaction, such as the use of carbon dioxide and thiophene derivatives in a metal catalyst and under suitable reaction conditions, the target 2-chloro-3-methoxythiophene-4-carboxylic acid can be generated.
Second, a thiophene ring can be constructed through a multi-step reaction starting from a simple sulfur-containing, oxygen-containing and carbon-containing compound. First, thiophene derivatives are formed by cyclization of compounds such as mercaptan, aldehyde and ketone under acidic or basic catalytic conditions. After that, methoxylation, chlorination and carboxylation are carried out in sequence. Methoxylation such as the above nucleophilic substitution method, chlorination and carboxylation also follow the common organic synthesis path. During chlorination, attention should be paid to the reaction selectivity, and carboxylation should pay attention to the effect of reaction conditions on the yield of the product.
Third, we can also learn from the synthesis ideas of similar compounds reported in the literature, and optimize the existing synthesis route according to the structural characteristics of 2-chloro-3-methoxythiophene-4-carboxylic acid. Such as changing the reaction sequence, first carboxylation, then chlorination and methoxylation, or choosing different reaction reagents to improve the reaction efficiency, improve the purity and yield of the product. At the same time, it is necessary to pay close attention to the control of the reaction conditions at each step during the reaction process, such as temperature, reaction time, proportion of reactants, etc., all of which play a key role in the formation of the final product.

2-Chloro-3-methoxythiophene-4-carboxylic acid is an organic compound. When storing, many key things need to be paid attention to.
First, temperature conditions are quite important. This compound is more sensitive to temperature, and high temperature is easy to cause it to decompose or deteriorate. Therefore, it should be stored in a cool place, and the temperature should be controlled at 2-8 ° C. This temperature range is similar to the cool and refreshing of the ancient caves in the mountains, which can protect its chemical stability and protect it from drastic temperature changes.
Second, the influence of humidity should not be ignored. Humid environment can easily lead to deliquescence or chemical reactions. Therefore, it needs to be stored in a dry place. If conditions permit, a desiccant, such as silica gel, can be placed in the storage place to absorb moisture and prevent moisture, just like creating a dry chamber for it to prevent moisture erosion.
Third, light is also a key factor. Light may cause photochemical reactions and cause structural changes. Therefore, it should be stored in a dark place, such as a brown bottle or in a dark warehouse, as if it is covered with a dark curtain to protect it from light.
Fourth, the packaging must be tight. Use well-sealed packaging materials to prevent contact with air, avoid oxidation or reaction with other components in the air, just like building a strong armor to resist external intrusion.
Fifth, isolated storage should not be ignored. This compound should not be mixed with oxidizing agents, reducing agents, acids, bases and other substances, because it may react violently with them and cause danger. It is necessary to separate it from these substances to ensure the safety of the storage environment, just like a clearly divided camp, each in its place and not interfering with each other.
Only by properly paying attention to the above storage points can we ensure the quality and stability of 2-chloro-3-methoxythiophene-4-carboxylic acid during storage for subsequent use.

Now look at the market price of "2-chloro-3-methoxythiophene-4-carboxylic acid" you asked about. However, the price of this product often changes for many reasons, and it is difficult to determine the specific number.
First, the preparation is difficult and easy, and the impact is quite large. If the preparation method is complicated, many steps are required, and expensive raw materials and special equipment are used, the price must be high. If the preparation is easy, the price may be relatively low.
Second, the market supply and demand situation is also the key. If there are many people who want it, but there are few products, the supply is in short supply, and the price will rise; on the contrary, if the supply exceeds the demand, the price will drop.
Third, the quality level is related to the price. High purity and high quality, the price must be higher than ordinary ones. Because it may be more suitable for high-end experiments and special production.
Fourth, the price varies depending on the supplier. Large factories may have high prices due to brand, reputation and quality control; small factories may have low prices due to low costs, but the quality may vary.
In the world of "Tiangong Kaiwu", although there are no such fine chemicals, the supply, demand and process are the same. Now to know its exact market price, you should consult chemical raw material suppliers, chemical reagent sales platforms, or refer to chemical product price information websites to get more accurate numbers.