2-bromothiophene-3-carboxylic acid

2-Bromothiophene-3-carboxylic acid, this is an organic compound. Its physical properties are unique and valuable for investigation.
Looking at its appearance, under room temperature and pressure, it often takes a solid form, mostly white to light yellow crystalline powder, just like a delicate frost powder, with pure color and fine texture. This appearance feature is an important basis for its visual identification.
The melting point is about 150-155 ° C. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. When the temperature gradually rises to this range, 2-bromothiophene-3-carboxylic acid melts like ice in spring and quietly melts from solid to liquid state. This property is of great significance in experimental operations such as substance identification and purification.
Solubility is also one of its key physical properties. In organic solvents, such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), etc., it exhibits good solubility, just like salts melt in water, and can mix with these organic solvents to form a uniform and stable solution. However, in water, its solubility is poor, and the insoluble state is like oil floating in water. This property is closely related to the hydrophilicity and hydrophobicity of the groups contained in the molecular structure. Some parts of the intramolecular thiophene ring and bromine atom are hydrophobic, making it insoluble in water, while the molecular structure and force of organic solvents are more suitable for the compound, so it can be dissolved.
In addition, the density of 2-bromothiophene-3-carboxylic acid also has characteristics, although the exact value will vary slightly due to measurement conditions, roughly 1.7-1.8 g/cm ³. The density reflects the mass of a substance per unit volume, like a scale for measuring the compactness of a substance. This density value indicates that the time division of the solid state is relatively close.
The physical properties of 2-bromothiophene-3-carboxylic acids mentioned above are crucial factors to consider in many fields such as organic synthesis and drug development, laying a solid foundation for their application and research.

2-Bromothiophene-3-carboxylic acid, this is an organic compound with many unique chemical properties.
Its acidity is significant, because the carboxyl group can release protons and can be partially ionized in water, it is acidic. This acidity allows it to react with alkali substances to form corresponding carboxylic salts and water. If reacted with sodium hydroxide, sodium 2-bromothiophene-3-carboxylate is obtained with water.
The presence of halogenated bromine makes it nucleophilic substitution reactive. The bromine atom can be replaced by many nucleophilic reagents. Nucleophilic reagents such as alcohols and amines can undergo nucleophilic substitution with 2-bromothiophene-3-carboxylic acids to form new organic compounds. If alcohol is used as a nucleophilic reagent, under suitable conditions, the bromine atom can be replaced by alkoxy groups to form corresponding ester compounds.
The conjugated structure of the thiophene ring makes 2-bromothiophene-3-carboxylic acid have certain stability and aromaticity. This structure makes it possible to participate in some reactions related to aromatic compounds, such as electrophilic substitution reactions. Under certain conditions, electrophilic reagents can attack the thiophene ring and substitution reactions occur at specific positions on the ring.
The carboxyl group of 2-bromothiophene-3-carboxylic acid can also participate in the esterification reaction. Under acid catalysis, it reacts with alcohol to form esters and water. This reaction is often used in organic synthesis to prepare ester compounds to change the properties and uses of the compounds.
In terms of redox reactions, some groups in the 2-bromothiophene-3-carboxylic acid molecule can be oxidized or reduced under appropriate conditions. For example, carboxyl groups can be reduced to alcohol hydroxyl groups under the action of specific strong reducing agents, and thiophene rings may also undergo structural changes due to the action of oxidizing agents.
These chemical properties make 2-bromothiophene-3-carboxylic acid widely used in the field of organic synthesis, and can be used as an intermediate for the synthesis of more complex organic compounds, which is of great value in the fields of medicinal chemistry and materials science.

The common synthesis methods of 2-bromothiophene-3-carboxylic acid generally include the following.
First, thiophene-3-carboxylic acid is used as the starting material. The thiophene-3-carboxylic acid is first brominated. In this process, suitable brominating reagents, such as bromine (\ (Br_ {2}\)), can be selected under suitable reaction conditions, such as in a specific solvent, and there is a suitable catalyst, so that the bromine atom replaces the hydrogen atom at a specific position on the thiophene ring, thereby generating 2-bromothiophene-3-carboxylic acid. However, this process needs to pay attention to the selectivity of the reaction, because different positions of the thiophene ring have different activities for the bromination reaction, and the conditions need to be precisely adjusted to obtain the target product.
Second, start from thiophene. First, carboxylation of thiophene can be carried out, and carboxyl groups can be introduced by suitable methods. For example, thiophene reacts with carbon dioxide under specific catalysts and reaction conditions to generate thiophene-3-carboxylic acid. Subsequently, thiophene-3-carboxylic acid is brominated as described above to obtain 2-bromothiophene-3-carboxylic acid. There are slightly more steps in this path, but each step needs to carefully control the reaction conditions to ensure higher yield and purity.
Third, some compounds containing thiophene structures can be synthesized through a series of functional group conversion reactions. For example, some thiophene derivatives with functional groups that can be converted into carboxyl groups and bromine atoms can be synthesized by step reaction. The relevant functional groups are first converted into carboxyl groups, and then bromine atoms are introduced in suitable steps to achieve the synthesis of 2-bromothiophene-3-carboxylic acid. This method requires high selection of starting materials, and each step of the reaction needs to carefully design the reaction sequence and conditions according to the raw material structure and target product requirements.

2-Bromothiophene-3-carboxylic acid is useful in various fields. In the field of medicinal chemistry, this compound is of great value. Because of its unique structure, it can be used as a key intermediate to synthesize drugs with specific pharmacological activities. For example, when developing antibacterial drugs, by virtue of its participation in the reaction, new compounds that can inhibit specific bacteria may be derived. Through its thiophene ring and bromine and carboxyl groups, it interacts with specific targets of bacteria, blocking the metabolic pathway of bacteria or affecting their reproduction process.
In the field of materials science, 2-bromothiophene-3-carboxylic acid can also be used. It can participate in the synthesis of polymer materials. By ingeniously designing the reaction, it is introduced into the main chain or side chain of the polymer to endow the material with novel properties. For example, it can enhance the photoelectric properties of the material, making the resulting material have potential applications in devices such as organic Light Emitting Diode (OLED) or solar cells, or improve the stability and solubility of the material, and broaden the application scenarios of the material.
Furthermore, in the field of organic synthetic chemistry, it is an important synthetic building block. Chemists can build complex organic molecular structures by virtue of its bromine atom prone to substitution reactions and carboxyl groups can participate in various condensation reactions. By selecting different reaction conditions and reagents, we can achieve diverse functional group transformation and molecular skeleton construction, providing rich strategies and means for the development of organic synthetic chemistry, assisting the creation of new organic compounds, and then promoting technological innovation and progress in related fields.

2-Bromothiophene-3-carboxylic acid is a kind of organic compound. It is not easy to know its market price, and its price often varies due to many factors.
First, the price of raw materials has a great influence. If the starting material required for the synthesis of this compound is abundant and the price is low, the price of 2-bromothiophene-3-carboxylic acid may decrease; conversely, if the raw material is scarce and expensive, the price will rise.
Second, the preparation process is also related. If a new efficient and low-cost preparation method is developed, the production cost can be reduced, and the price may be lowered; while the complex and expensive process will lead to high cost and high price.
Third, the market supply and demand situation is critical. If the market demand for this product is strong and the supply is limited, the price will rise; if the demand is low and the supply is excessive, the price will fall.
Fourth, regional differences cannot be ignored. Different regions have different prices due to different economic levels, transportation costs, tax policies, etc. In places with developed economy and large demand, the price may be higher; while in remote places with little demand, the price may be lower.
Based on past market conditions, the price of this compound fluctuates greatly. It may rise to a higher price from time to time, or fall to a lower range due to changes in conditions. To obtain the exact current market price, it is advisable to consult professional chemical product suppliers, traders, or professional chemical market information platforms to obtain accurate prices.